Suchergebnisse

Corkery, D.; Ursu, A.; Lucas, B.; Grigalunas, M.; Kriegler, S.; Oliva, R.; Dec, R.; Koska, S.; Pahl, A.; Sievers, S. et al.; Ziegler, S.; Winter, R.; Wu, Y.; Waldmann, H.: Inducin Triggers LC3-Lipidation and ESCRT-Mediated Lysosomal Membrane Repair. ChemBioChem: A European Journal of Chemical Biology (2023)

Xie, J.; Pahl, A.; Krzyzanowski, A.; Krupp, A.; Liu, J.; Koska, S.; Schölermann, B.; Zhang, R.; Bonowski, J.; Sievers, S. et al.; Strohmann, C.; Ziegler, S.; Grigalunas, M.; Waldmann, H.: Synthetic Matching of Complex Monoterpene Indole Alkaloid Chemical Space. Angewandte Chemie, International Edition in English (2023)

Krzyzanowski, A.; Pahl, A.; Grigalunas, M.; Waldmann, H.: Spacial Score─A Comprehensive Topological Indicator for Small-Molecule Complexity. Journal of Medicinal Chemistry (2023)

Liu, J.; Zhang, R.; Mallick, S.; Wientjens, C.; Flegel, J.; Krupp, A.; Strohmann, C.; Grassing, C.; Merten, C.; Pahl, A. et al.; Grigalunas, M.; Waldmann, H.: A highly enantioselective intramolecular 1,3-dipolar cycloaddition yields novel pseudo-natural product inhibitors of the Hedgehog signalling pathway. Chemical Science 14 (2023)

Pahl, A.; Schölermann, B.; Lampe, P.; Rusch, M.; Dow, M.; Hedberg, C.; Nelson, A.; Sievers, S.; Waldmann, H.; Ziegler, S.: Morphological subprofile analysis for bioactivity annotation of small molecules. Cell Chemical Biology (2023)

Liu, J.; Malick, S.; Grassin, C.; Lucas, B.; Schölermann, B.; Pahl, A.; Scheel, R.; Strohmann Carsten; Protzel, C.; Berg, T. et al.; Merten, C.; Waldmann, H.: Morphological profiling identifies the motor protein Eg5 as cellular target of spirooxindoles. Angewandte Chemie, International Edition in English (2023)

Pkolo, E. A.; Pahl, A.; Sievers, S.; Nelson, A.; Marsden, S.: Scaffold Remodelling of Diazaspirotricycles Enables Synthesis of Diverse sp3-Rich Compounds With Distinct Phenotypic Effects. Chemistry – A European Journal (2023)

Withmarsh-Everiss, T.; Wang, Z.; Hauberg Hansen, C.; Depta, L.; Sassetti, E.; Dan, O. R.; Pahl, A.; Sievers, S.; Laraia, L.: Identification of biologically diverse tetrahydronaphtalen-2-ols through the synthesis and phenotypic profiling of chemically diverse, estradiol-inspired compounds. ChemBioChem: A European Journal of Chemical Biology (2023)

Schölermann, B.; Bonowski, J.; Grigalunas, M.; Burhop, A.; Xie, Y.; Hook, J.; Liu, J.; Nelson, A.; Dow, M.; Nowak, C. et al.; Pahl, A.; Sievers, S.; Ziegler, S.: Identification of Dihydroorotate Dehydrogenase Inhibitors using the Cell Painting Assay. ChemBioChem: A European Journal of Chemical Biology (2022)

Grigalunas, M.; Patil, S.; Krzyzanowski, A.; Pahl, A.; Flegel, J.; Schölermann, B.; Xie, J.; Sievers, S.; Ziegler, S.; Waldmann, H.: Unprecedented Combination of Polyketide Natural Product Fragments Identifies the New Hedgehog Signaling Pathway Inhibitor Grismonone. Chemistry – A European Journal (2022)

Akbarzadeh, M.; Deipenwisch, I.; Schoelermann, B.; Pahl, A.; Sievers, S.; Ziegler, S.; Waldmann, H.: Morphological profiling by means of the Cell Painting assay enables identification of tubulin-targeting compounds. Cell Chemical Biology, S. 1053 - 1064 (2022)

Akbarzadeh, M.; Deipenwisch, I.; Schoelermann, B.; Pahl, A.; Sievers, S.; Ziegler, S.; Waldmann, H.: Morphological profiling by means of the Cell Painting assay enables identification of tubulin-targeting compounds. Cell Chemical Biology, S. 1 - 16 (2021)

Schneidewind, T.; Brause, A.; Schölermann, B.; Sievers, S.; Pahl, A.; Sankar, M. G.; Winzker, M.; Janning, P.; Kumar, K.; Ziegler, S. et al.; Waldmann, H.: Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis. Cell Chemical Biology 28 (12), S. 1780 - 1794 (2021)

Gally, J.-M.; Pahl, A.; Czodrowski, P.; Waldmann, H.: Pseudonatural Products Occur Frequently in Biologically Relevant Compounds. Journal of Chemical Information and Modeling 61 (11), S. 5458 - 5468 (2021)

Burhop, A.; Bag, S.; Grigalunas, M.; Woitalla, S.; Bodenbinder, P.-J.; Brieger, L.; Strohmann, C.; Pahl, A.; Sievers, S.; Waldmann, H.: Synthesis of Indofulvin Pseudo-Natural Products Yields a New Autophagy Inhibitor Chemotype. Advanced Science 8 (19), e2102042, S. 1 - 10 (2021)

Liu, J.; Flegel, J.; Otte, F.; Pahl, A.; Sievers, S.; Strohmann, C.; Waldmann, H.: Combination of Pseudo-Natural Product Design and Formal Natural Product Ring Distortion Yields Stereochemically and Biologically Diverse Pseudo-Sesquiterpenoid Alkaloids. Angewandte Chemie International Edition 60 (39), S. 21384 - 21395 (2021)

Liu, J.; Flegel, J.; Otte, F.; Pahl, A.; Sievers, S.; Strohmann, C.; Waldmann, H.: Combination of Pseudo-Natural Product Design and Formal Natural Product Ring Distortion Yields Stereochemically and Biologically Diverse Pseudo-Sesquiterpenoid Alkaloids. Angewandte Chemie 133 (39), S. 21554 - 21565 (2021)

Leder, C.; Suk, M.; Lorenz, S.; Rastogi, T.; Peifer, C.; Kietzmann, M.; Jonas, D.; Buck, M.; Pahl, A.; Kümmerer, K.: Reducing Environmental Pollution by Antibiotics through Design for Environmental Degradation. ACS Sustainable Chemistry & Engineering 9 (28), S. 9358 - 9368 (2021)

Grigalunas, M.; Burhop, A.; Zinken, S.; Pahl, A.; Gally, J.-M.; Wild, N.; Mantel, Y.; Sievers, S.; Foley, D. J.; Scheel, R. et al.; Strohmann, C.; Antonchick, A. P.; Waldmann, H.: Natural product fragment combination to performance-diverse pseudo-natural products. Nature Communications 12 (1), 1883, S. 1 - 11 (2021)

Liu, J.; Cremosnik, G. S.; Otte, F.; Pahl, A.; Sievers, S.; Strohmann, C.; Waldmann, H.: Design, synthesis and biological evaluation of chemically and biologically diverse pyrroquinoline pseudo natural products. Angewandte Chemie International Edition 60 (9), S. 4648 - 4656 (2020)