The research of the group is based on chemical synthesis. We focus on the development of novel methods for the synthesis of small compounds and following application of the developed reaction methodology for preparation of focused compound libraries. The obtained compounds are studied using cell based assays and chemical genetic approaches to evaluate possible targets. Furthermore, we are elaborating new synthetic strategies for the preparation of complex lead molecules with pronounced bioactivity. The group’s research covers several complementary areas of organic synthesis for the development of novel efficient reaction methodologies, such as:
• Enantioselective catalysis for the synthesis of complex chiral products with multiple stereocenters.
• C-H bond activation using transition metal catalysis for direct coupling of non-functionalized compounds.
• C-H bond functionalization based on utilization of direct oxidative metal-free methods for the synthesis of compounds of interest.
Matcha K and Antonchick AP (2014). Cascade Multicomponent Synthesis of Indoles, Pyrazoles, and Pyridazinones by Functionalization of Alkenes. Angew Chem Int Ed 53, 11960-11964.
Manna S and Antonchick AP (2016). [1+1+1] Cyclotrimerization for the Synthesis of Cyclopropanes. Angew Chem Int Ed 55, 5290-5293.
Matcha K, Narayan R, and Antonchick AP (2013). Metal-Free Radical Azidoarylation of Alkenes: Rapid Access to Oxindoles by Cascade C-N and C-C Bond-Forming Reactions. Angew Chem Int Ed 52, 7985-7989.
Manna S and Antonchick AP (2014). Organocatalytic Oxidative Annulation of Benzamide Derivatives with Alkynes. Angew Chem Int Ed 53, 7324-7327.
Manna S, Matcha K, and Antonchick AP (2014). Metal-Free Annulation of Arenes with 2-Aminopyridine Derivatives: The Methyl Group as a Traceless Non-Chelating Directing Group. Angew Chem Int Ed 53, 8163-8166.