Peter Bieling

Regulatory mechanisms of cell morphology 



Contact

Phone: +49 (0231) 133 - 2248
Fax:+49 (231) 133 - 2299

Research Interests

The primary focus of my research group on "Systems Biochemistry" is to reveal the molecular mechanisms that regulate changes in cell morphology through the cytoskeleton and the underlying polarization of the signaling molecules that control these processes. Instead of studying membrane polarity and cytoskeletal morphogenesis in their complex cellular environment, we aim to reconstitute these processes in minimal systems from purified components in vitro. This allows us to study and manipulate all biochemical activities in great detail to reveal the fundamental principles underlying self-organization of morphogenic signaling systems. As part of the MaxSynBio initiative and in synergy with recent research innovations in the Bastiaens department, we develop novel concepts and cutting edge methodology in systems biochemistry (multiprotein reconstitution, encapsulation) and combine these approaches with advanced fluorescence imaging (TIRFM, FLIM).

Selected Publications

Reversible cryo-arrest for imaging molecules in living cells at high spatial resolution. Bieling P, Li TD, Weichsel J, McGorty R, Jreij P, Huang B, Fletcher DA, Mullins RD (2016). Force Feedback Controls Motor Activity and Mechanical Properties of Self-Assembling Branched Actin Networks. Cell 164(1-2):115-27
doi: 10.1016/j.cell.2015.11.057.

Köster DV, Husain K, Iljazi E, Bhat A, Bieling P, Mullins RD, Rao M, Mayor S (2016). Actomyosin dynamics drive local membrane component organization in an in vitro active composite layer. Proc Natl Acad Sci U S A 113(12):E1645-54.  
doi: 10.1073/pnas.1514030113.

Bieling P, Telley IA, Surrey T (2010). A minimal midzone protein module controls formation and length of antiparallel microtubule overlaps. Cell 142(3):420-32.
doi: 10.1016/j.cell.2010.06.033.

Bieling P, Laan L, Schek H, Munteanu EL, Sandblad L, Dogterom M, Brunner D, Surrey T (2007). Reconstitution of a microtubule plus-end tracking system in vitro. Nature 450(7172):1100-5
doi: 10.1038/nature06386;


 
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