Selforganization of the cytoskeleton
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The development and function of multicellular organisms critically depends on regulated cell morphology changes. Perturbations in the signal networks that control those changes can lead to developmental anomalies or cancer. In our research group, we investigate how the morphology and function of mammalian cells is controlled by such signal networks. We particularly focus on self-organizing pattern forming mechanisms that emerge from coupled reactions and diffusion of molecules inside individual cells [1-3]. To study those systems, we implement an interdisciplinary approach [4,5] that combines acute, microscopy-based experimental perturbations, the development of novel analysis technologies and mathematical modeling.