Leif Dehmelt

Selforganization of the cytoskeleton



Contact

Phone:+49 (231) 755 7057
Fax:+49 (231) 133 - 2299

Graessl M, Koch J, Calderon A, Kamps D, Banerjee S, Mazel T, Schulze N, Jungkurth JK, Patwardhan R, Solouk D, Hampe N, Hoffmann B, Dehmelt L, Nalbant P (2017). An excitable Rho GTPase signaling network generates dynamic subcellular contraction patterns. J Cell Biol 21(14):5311-6.
doi: 10.1083/jcb.201706052.


Kamps D, Dehmelt L (2017). Deblurring Signal Network Dynamics. ACS Chem Biol 12(9):2231-2239.
doi: 10.1021/acschembio.7b00451.


Chen X, Venkatachalapathy M, Kamps D, Weigel S, Kumar R, Orlich M, Garrecht R, Hirtz M, Niemeyer CM, Wu YW, Dehmelt L. (2017). "Molecular-Activity Painting": Switch-like, Light-Controlled Perturbations inside Living Cells. Angew Chem Int Ed Engl 21(14):5311-6.
doi: 10.1002/anie.201611432



2015

Arndt HD, Rizzo S, Nöcker C, Wakchaure VN, Milroy LG, Bieker V, Calderon A, Tran TT, Brand S,Dehmelt L, Waldmann H (2015). Divergent solid-phase synthesis of natural product-inspired bipartite cyclodepsipeptides: total synthesis of seragamide A. Chemistry 21(14):5311-6.
doi: 10.1002/chem.201500368.



2014





Liu P, Calderon A, Konstantinidis G, Hou J, Voss S, Chen X, Li F, Banerjee S, Hoffmann JE, Theiss C, Dehmelt L, Wu YW (2014). A bioorthogonal small-molecule-switch system for controlling protein function in live cells. Angew Chem Int Ed Engl 53(38):10049-55.
doi: 10.1002/anie.201403463.

Dehmelt L (2014). Cytoskeletal self-organization in neuromorphogenesis. Bioarchitecture 4:75 (2014)
doi: 10.4161/bioa.29070.

Arrabito G, Schroeder H, Schröder K, Filips C, Marggraf U, Dopp C, Venkatachalapathy M, Dehmelt L, Bastiaens PI, Neyer A, Niemeyer CM (2014). Configurable low-cost plotter device for fabrication of multi-color sub-cellular scale microarrays. Small 10(14):2870-6. doi: 10.1002/smll.201303390.
doi: 10.4161/bioa.29070.

Mazel T, Biesemann A, Krejczy M, Nowald J, Müller O, Dehmelt L (2014). Direct observation of microtubule pushing by cortical dynein in living cells. Mol Biol Cell 25(1):95-106.
doi: 10.1091/mbc.E13-07-0376.

Schulze N, Graessl M, Blancke Soares A, Geyer M, Dehmelt L, Nalbant P (2014). FHOD1 regulates stress fiber organization by controlling the dynamics of transverse arcs and dorsal fibers. J Cell Sci 127(Pt 7):1379-93. doi: 10.1242/jcs.134627.
doi: 10.1242/jcs.134627.


2013





Arens J, Duong TT, Dehmelt L (2013). A morphometric screen identifies specific roles for microtubule-regulating genes in neuronal development of P19 stem cells. PLoS One 8(11):e79796.
doi: 10.1371/journal.pone.0079796.

Arrabito G, Reisewitz S, Dehmelt L, Bastiaens PI, Pignataro B, Schroeder H, Niemeyer CM (2013). Biochips for cell biology by combined dip-pen nanolithography and DNA-directed protein immobilization. Small 9(24):4243-9.
doi: 10.1002/smll.201300941.

Gandor S, Reisewitz S, Venkatachalapathy M, Arrabito G, Reibner M, Schröder H, Ruf K, Niemeyer CM, Bastiaens PI, Dehmelt L (2013). A protein-interaction array inside a living cell. Angew Chem Int Ed Engl 52(18):4790-4.
doi: 10.1002/anie.201209127.

Schönichen A, Mannherz HG, Behrmann E, Mazur AJ, Kühn S, Silván U, Schoenenberger CA, Fackler OT, Raunser S, Dehmelt L, Geyer M (2013). FHOD1 is a combined actin filament capping and bundling factor that selectively associates with actin arcs and stress fibers. J Cell Sci 126(Pt 8):1891-901.
doi: 10.1242/jcs.126706.

Blümer J, Rey J, Dehmelt L, Mazel T, Wu YW, Bastiaens P, Goody RS, Itzen A (2013). RabGEFs are a major determinant for specific Rab membrane targeting. J Cell Biol 200(3):287-300.
doi: 10.1083/jcb.201209113.


2012





Arens J, Duong TT, Dehmelt L (2013). A morphometric screen identifies specific roles for microtubule-regulating genes in neuronal development of P19 stem cells. PLoS One 8(11):e79796. doi: 10.1371/journal.pone.0079796.
doi: 10.1371/journal.pone.0079796.

Tennstaedt A, Pöpsel S, Truebestein L, Hauske P, Brockmann A, Schmidt N, Irle I, Sacca B, Niemeyer CM, Brandt R, Ksiezak-Reding H, Tirniceriu AL, Egensperger R, Baldi A, Dehmelt L, Kaiser M, Huber R, Clausen T, Ehrmann M (2012). Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates. J Biol Chem 287(25):20931-41.
doi: 10.1074/jbc.M111.316232.

Milroy LG, Rizzo S, Calderon A, Ellinger B, Erdmann S, Mondry J, Verveer P, Bastiaens P, Waldmann H, Dehmelt L, Arndt HD (2012). Selective chemical imaging of static actin in live cells. J Am Chem Soc134(20):8480-6.
doi: 10.1021/ja211708z.


2011





Dehmelt L, Poplawski G, Hwang E, Halpain S (2011). NeuriteQuant: an open source toolkit for high content screens of neuronal morphogenesis. BMC Neurosci 12:100.
doi: 10.1186/1471-2202-12-100.

Fath T, Fischer RS, Dehmelt L, Halpain S, Fowler VM (2011). Tropomodulins are negative regulators of neurite outgrowth. Eur J Cell Biol90(4):291-300.
doi: 10.1016/j.ejcb.2010.10.014.


before 2011





Dehmelt L, Bastiaens PI (2010). Spatial organization of intracellular communication: insights from imaging. Nat Rev Mol Cell Biol 11(6):440-52.
doi: 10.1038/nrm2903.

Weinrich D, Köhn M, Jonkheijm P, Westerlind U, Dehmelt L, Engelkamp H, Christianen PC, Kuhlmann J, Maan JC, Nüsse D, Schröder H, Wacker R, Voges E, Breinbauer R, Kunz H, Niemeyer CM, Waldmann H (2010). Preparation of biomolecule microstructures and microarrays by thiol-ene photoimmobilization. Chembiochem 11(2):235-47.
doi: 10.1002/cbic.200900559.

Dehmelt L, Halpain S (2007). Neurite outgrowth: a flick of the wrist. Curr Biol17(15):R611-4.
http://dx.doi.org/10.1016/j.cub.2007.05.059

Dehmelt L, Nalbant P, Steffen W, Halpain S (2006). A microtubule-based, dynein-dependent force induces local cell protrusions: Implications for neurite initiation. Brain Cell Biol35(1):39-56.
doi: 10.1007/s11068-006-9001-0

Halpain S, Dehmelt L (2006). The MAP1 family of microtubule-associated proteins. Genome Biol7(6):224. Review.
doi:  10.1186/gb-2006-7-6-224

Dehmelt L, Halpain S (2005). The MAP2/Tau family of microtubule-associated proteins. Genome Biol6(1):204.
doi: 10.1186/gb-2004-6-1-204

Roger B, Al-Bassam J, Dehmelt L, Milligan RA, Halpain S (2004). MAP2c, but not tau, binds and bundles F-actin via its microtubule binding domain. Curr Biol14(5):363-71.
http://dx.doi.org/10.1016/j.cub.2004.01.058

Dehmelt L, Halpain S (2004). Actin and microtubules in neurite initiation: are MAPs the missing link? J Neurobiol 58(1):18-33. Review.
doi: 10.1002/neu.10284

Werner A, Preston-Fayers K, Dehmelt L, Nalbant P (2002). Regulation of the NPT gene by a naturally occurring antisense transcript. Cell Biochem Biophys 36(2-3):241-52. Review.
doi: 10.1385/CBB:36:2-3:241

Lerche C, Seebohm G, Wagner CI, Scherer CR, Dehmelt L, Abitbol I, Gerlach U, Brendel J, Attali B, Busch AE (2000). Molecular impact of MinK on the enantiospecific block of I(Ks) by chromanols. Br J Pharmacol 131(8):1503-6.
doi: 10.1038/sj.bjp.0703734

Nalbant P, Boehmer C, Dehmelt L, Wehner F, Werner A (1999). Functional characterization of a Na+-phosphate cotransporter (NaPi-II) from zebrafish and identification of related transcripts. J Physiol520 Pt 1:79-89.
doi: 10.1111/j.1469-7793.1999.00079.x

Werner A, Dehmelt L, Nalbant P (1998). Na+-dependent phosphate cotransporters: the NaPi protein families. J Exp Biol201(Pt 23):3135-42. Review.
PMID: 9808829


 
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