Frank Wehner

Mechanisms of cell volume regulation


Phone: +49 (0231) 133 - 2225
Fax: +49 (0231) 133 - 2299

Huebinger J, Masip ME, Christmann J, Wehner F, Bastiaens PIH. (2017). Reversible Cryo-arrests of Living Cells to Pause Molecular Movements for High-resolution Imaging. Bio Protoc
doi: 10.21769/BioProtoc.2236.


Masip ME, Huebinger J, Christmann J, Sabet O, Wehner F, Konitsiotis A, Fuhr GR, Bastiaens PI (2016). Reversible cryo-arrest for imaging molecules in living cells at high spatial resolution. Nat Methods 13(8):665-72.
doi: 10.1038/nmeth.3921.

Christmann J, Azer L, Dörr D, Fuhr GR, Bastiaens PI, Wehner F (2016). Adaptive responses of cell hydration to a low temperature arrest. J Physiol594(6):1663-76.
doi: 10.1113/JP271245.


Numata T, Sato K, Christmann J, Marx R, Mori Y, Okada Y, Wehner F (2012). The ΔC splice-variant of TRPM2 is the hypertonicity-induced cation channel in HeLa cells, and the ecto-enzyme CD38 mediates its activation. J Physiol 590(5):1121-38.
doi: 10.1113/jphysiol.2011.220947.

Before 2011

Bondarava M, Li T, Endl E, Wehner F (2009). alpha-ENaC is a functional element of the hypertonicity-induced cation channel in HepG2 cells and it mediates proliferation. Pflugers Arch 458(4):675-87.
doi: 10.1007/s00424-009-0649-z

Numata T, Sato K, Okada Y, Wehner F (2008). Hypertonicity-induced cation channels rescue cells from staurosporine-elicited apoptosis. Apoptosis 13(7):895-903.
doi: 10.1007/s10495-008-0220-y.

Plettenberg S, Weiss EC, Lemor R, Wehner F (2008). Subunits alpha, beta and gamma of the epithelial Na+ channel (ENaC) are functionally related to the hypertonicity-induced cation channel (HICC) in rat hepatocytes. Pflugers Arch 455(6):1089-95.
doi: 10.1007/s00424-007-0355-7

Wehner F, Nören-Müller A, Müller O, Reis-Corrêa I Jr, Giannis A, Waldmann H. Indoloquinolizidine derivatives as novel and potent apoptosis inducers and cell-cycle blockers. Chembiochem 9(3):401-5. doi: 10.1002/cbic.200700558.
doi: 10.1002/cbic.200700558.

Numata T, Wehner F, Okada Y (2007). A novel inhibitor of hypertonicity-induced cation channels in HeLa cells. J Physiol Sci 57(4):249-52.

Bierhals K, Sondersorg AC, Lin CT, Rosenbaum C, Waldmann H, Wehner F (2007). The epsilon-isoform of PKC mediates the hypertonic activation of cation channels in confluent monolayers of rat hepatocytes. Cell Physiol Biochem 20(5):397-404.

Wehner F, Numata T, Subramanyan M, Takahashi N, Okada Y (2007). Signalling events employed in the hypertonic activation of cation channels in HeLa cells. Cell Physiol Biochem 20(1-4):75-82.

Olsen H, ter Veld F, Herbrand U, Ahmadian MR, Kinne RK, Wehner F (2007). Differential regulation of cell volume and shape in confluent rat hepatocytes under hypertonic stress. Cell Physiol Biochem 19(5-6):259-68.
doi: 10.1159/000100645

Shimizu T, Wehner F, Okada Y (2006). Inhibition of hypertonicity-induced cation channels sensitizes HeLa cells to shrinkage-induced apoptosis. Cell Physiol Biochem 18(6):295-302.
doi: 10.1159/000097607.

Wehner F (2006). Cell volume-regulated cation channels. Contrib Nephrol 152:25-53. Review.
doi: 10.1159/000096315

Li T, ter Veld F, N rnberger HR, Wehner F (2005). A novel hypertonicity-induced cation channel in primary cultures of human hepatocytes. FEBS Lett 579(10):2087-91.
doi: 10.1016/j.febslet.2005.02.060

Wehner F, Olsen H (2004). Hypertonicity-induced cation channels in rat hepatocytes and their intracellular regulation. Adv Exp Med Biol 559:253-61. Review.
Book Chapter

Wehner F, Shimizu T, Sabirov R, Okada Y (2003). Hypertonic activation of a non-selective cation conductance in HeLa cells and its contribution to cell volume regulation. FEBS Lett 551(1-3):20-4.

Lawonn P, Hoffmann EK, Hougaard C, Wehner F (2003). A cell shrinkage-induced non-selective cation conductance with a novel pharmacology in Ehrlich-Lettre-ascites tumour cells. FEBS Lett 539(1-3):115-9.

Kirschner U, Van Driessche W, Werner A, Wehner F (2003). Hypertonic activation of phospholemman in solitary rat hepatocytes in primary culture. FEBS Lett 537(1-3):151-6.

Wehner F, Lawonn P, Tinel H (2002). Ionic mechanisms of regulatory volume increase (RVI) in the human hepatoma cell-line HepG2. Pflugers Arch 443(5-6):779-90.
doi:  10.1007/s00424-001-0765-x

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