heinz neumann

Applied Synthetic Biology


Phone: +49 (231) 133-2315 
Fax: +49 (231) 133-2399

Neumann H (2018). Bypassing Kinase Signaling in Mammalian Cells. Cell Chem Biol 47:453-462.
doi: 10.1016/j.chembiol.2018.09.001.

Spinck M, Ecke M, Sievers S, Neumann H (2018). Highly Sensitive Lysine Deacetylase Assay Based on Acetylated Firefly Luciferase. Bilochemistry 47:453-462.
doi: 10.1021/acs.biochem.8b00483.

Heitmüller S, Neumann-Staubitz P, Herrfurth C, Feussner I, Neumann H (2018). Cellular substrate limitations of lysine acetylation turnover by sirtuins investigated with engineered futile cycle enzymes. Metab Eng 47:453-462.
doi: 10.1016/j.ymben.2018.04.022.

Neumann H, Neumann-Staubitz P, Witte A, Summerer D (2018). Epigenetic chromatin modification by amber suppression technology. Curr Opin Chem Biol 45:1-9.
doi: 10.1016/j.cbpa.2018.01.017.

Hoffmann C, Neumann H, Neumann-Staubitz P (2018). Trapping Chromatin Interacting Proteins with Genetically Encoded, UV-Activatable Crosslinkers In Vivo. Methods Mol Biol 19;7:11310.
doi: 10.1007/978-1-4939-7574-7_16.


Kusch K, Uecker M, Liepold T, Möbius W, Hoffmann C, Neumann H, Werner HB, Jahn O (2017). Partial Immunoblotting of 2D-Gels: A Novel Method to Identify Post-Translationally Modified Proteins Exemplified for the Myelin Acetylome. Proteomes 5(1)
doi: 10.3390/proteomes5010003.

Neumann-Staubitz P, Neumann H (2016). The use of unnatural amino acids to study and engineer protein function. Curr Opin Struct Biol 38:119-28.
doi: 10.1016/j.sbi.2016.06.006.

Desfougères Y, Neumann H, Mayer A (2016). Organelle size control - increasing vacuole content activates SNAREs to augment organelle volume through homotypic fusion. J Cell Sci 129(14):2817-28.
doi: 10.1242/jcs.184382.

Hiragami-Hamada K, Soeroes S, Nikolov M, Wilkins B, Kreuz S, Chen C, De La Rosa-Velázquez IA, Zenn HM, Kost N, Pohl W, Chernev A, Schwarzer D, Jenuwein T, Lorincz M, Zimmermann B, Walla PJ, Neumann H, Baubec T, Urlaub H, Fischle W (2016). Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin. Nat Commun 19;7:11310.
doi: 10.1038/ncomms11310.

Antonin W, Neumann H (2016). Chromosome condensation and decondensation during mitosis. Curr Opin Cell Biol. 40:15-22.
doi: 10.1016/j.ceb.2016.01.013.


Kruitwagen T, Denoth-Lippuner A, Wilkins BJ, Neumann H, Barral Y (2015).Axial contraction and short-range compaction of chromatin synergistically promote mitotic chromosome condensation. Elife 28;4:e1039. doi: 10.7554/eLife.10396.
doi: 10.1016/j.ceb.2016.01.013.

Hoffmann C, Neumann H (2015). In Vivo Mapping of FACT-Histone Interactions Identifies a Role of Pob3 C-terminus in H2A-H2B Binding. ACS Chem Biol10(12):2753-63.
doi: 10.1021/acschembio.5b00493.

Halder K, Dölker N, Van Q, Gregor I, Dickmanns A, Baade I, Kehlenbach RH, Ficner R, Enderlein J, Grubmüller H, Neumann H (2015). MD simulations and FRET reveal an environment-sensitive conformational plasticity of importin-β. Biophys J. 109(2):277-86. doi: doi: 10.1016/j.bpj.2015.06.014.

Wilkins BJ, Hahn LE, Heitmüller S, Frauendorf H, Valerius O, Braus GH, Neumann H (2015). Genetically encoding lysine modifications on histone H4. ACS Chem Biol10(4):939-44.
doi: 10.1021/cb501011v.


Rakebrandt N, Lentes S, Neumann H, James LC, Neumann-Staubitz P (2014). Antibody- and TRIM21-dependent intracellular restriction of Salmonella enterica. Pathog Dis72(2):131-7.
doi: 10.1111/2049-632X.12192.

Lammers C, Hahn LE, Neumann H (2014). Optimized plasmid systems for the incorporation of multiple different unnatural amino acids by evolved orthogonal ribosomes. Chembiochem15(12):1800-4.
doi: 10.1002/cbic.201402033.

Wilkins BJ, Rall NA, Ostwal Y, Kruitwagen T, Hiragami-Hamada K, Winkler M, Barral Y, Fischle W, Neumann H (2014). A cascade of histone modifications induces chromatin condensation in mitosis. Science 343(6166):77-80.
doi: 10.1126/science.1244508.


Neumann H (2012). Rewiring translation - Genetic code expansion and its applications. FEBS Lett 586(15):2057-64.
doi: 10.1016/j.febslet.2012.02.002.


Kari V, Shchebet A, Neumann H, Johnsen SA (2011). The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair. Cell Cycle 10(20):3495-504.
doi: 10.4161/cc.10.20.17769.

before 2011

Neumann H, Neumann-Staubitz P (2010). Synthetic biology approaches in drug discovery and pharmaceutical biotechnology. Appl Microbiol Biotechnol 87(1):75-86.
doi: 10.1007/s00253-010-2578-3.

Lammers M, Neumann H, Chin JW, James LC (2010). Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization. Nat Chem Biol 6(5):331-7.
doi: 10.1038/nchembio.342.

Neumann H, Wang K, Davis L, Garcia-Alai M, Chin JW (2010). Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome. Nature 464(7287):441-4.

Neumann H, Slusarczyk AL, Chin JW (2010). De novo generation of mutually orthogonal aminoacyl-tRNA synthetase/tRNA pairs. J Am Chem Soc 132(7):2142-4.
doi: 10.1021/ja9068722.

Neumann H, Hancock SM, Buning R, Routh A, Chapman L, Somers J, Owen-Hughes T, van Noort J, Rhodes D, Chin JW (2009). A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation. Mol Cell. 36(1):153-63.
doi: 10.1016/j.molcel.2009.07.027.

Neumann H, Hancock SM, Buning R, Routh A, Chapman L, Somers J, Owen-Hughes T, van Noort J, Rhodes D, Chin JW (2009). A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation. Mol Cell. 36(1):153-63. doi: 10.1016/j.molcel.2009.07.027.

Nguyen DP, Garcia Alai MM, Kapadnis PB, Neumann H, Chin JW (2009). Genetically encoding N(epsilon)-methyl-L-lysine in recombinant histones. J Am Chem Soc 131(40):14194-5. doi: 10.1021/ja906603s.

Nguyen DP, Lusic H, Neumann H, Kapadnis PB, Deiters A, Chin JW (2009). Genetic encoding and labeling of aliphatic azides and alkynes in recombinant proteins via a pyrrolysyl-tRNA Synthetase/tRNA(CUA) pair and click chemistry. J Am Chem Soc 131(25):8720-1. doi: 10.1021/ja900553w.

Hothorn M, Neumann H, Lenherr ED, Wehner M, Rybin V, Hassa PO, Uttenweiler A, Reinhardt M, Schmidt A, Seiler J, Ladurner AG, Herrmann C, Scheffzek K, Mayer A (2009). Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase. Science 324(5926):513-6. doi: 10.1126/science.1168120.

Neumann H, Hazen JL, Weinstein J, Mehl RA, Chin JW (2008). Genetically encoding protein oxidative damage. J Am Chem Soc. 130(12):4028-33.
doi: 10.1021/ja710100d.

Neumann H, Peak-Chew SY, Chin JW (2008). Genetically encoding N(epsilon)-acetyllysine in recombinant proteins. Nat Chem Biol 4(4):232-4.
doi: 10.1038/nchembio.73

Wang K, Neumann H, Peak-Chew SY, Chin JW (2007). Evolved orthogonal ribosomes enhance the efficiency of synthetic genetic code expansion. Nat Biotechnol 25(7):770-7.

Uttenweiler A, Schwarz H, Neumann H, Mayer A (2007). The vacuolar transporter chaperone (VTC) complex is required for microautophagy. Mol Biol Cell 18(1):166-75.
doi: 10.1091/mbc.E06-08-0664

Staubitz P, Neumann H, Schneider T, Wiedemann I, Peschel A (2004). MprF-mediated biosynthesis of lysylphosphatidylglycerol, an important determinant in staphylococcal defensin resistance. FEMS Microbiol Lett231(1):67-71.
doi: http://dx.doi.org/10.1016/S0378-1097(03)00921-2

Müller O, Neumann H, Bayer MJ, Mayer A (2003). Role of the Vtc proteins in V-ATPase stability and membrane trafficking. J Cell Sci 116(Pt 6):1107-15.
doi: 10.1242/jcs.00328

Wissmann R, Bildl W, Neumann H, Rivard AF, Klöcker N, Weitz D, Schulte U, Adelman JP, Bentrop D, Fakler B (2002). A helical region in the C terminus of small-conductance Ca2+-activated K+ channels controls assembly with apo-calmodulin. J Biol Chem 277(6):4558-64.
doi: 10.1074/jbc.M109240200

Go to Editor View
loading content