Christos Gatsogiannis

Christos Gatsogiannis

Project Group Leader, Structural Biochemistry



Klink BU, Gatsogiannis C, Hofnagel O, Wittinghofer A, Raunser S (2020). Structure of the human BBSome core complex Elife


Leidreiter F, Roderer D, Meusch D, Gatsogiannis C, R. Benz R, Raunser S (2019). Common architecture of Tc toxins from human and insect pathogenic bacteria. Science Advances
doi: 10.1126/sciadv.aax6497.

Gatsogiannis C, Balogh D, Merino F, Sieber SA, Raunser S (2019). Cryo-EM structure of the ClpXP protein degradation machinery. Nat Struct Mol Bio
doi: 10.1038/s41594-019-0304-0.

Wagner T, Merino F, Stabrin S, Moriya T, Antoni C, Apelbau A, Hagel P, Sitsel O, Raisch T, Prumbaum D, Quentin D, Roderer D, Tacke S, Siebolds B, Schubert E, Shaikh TR, Lill P, Gatsogiannis C, Raunser S (2019). SPHIRE-crYOLO is a fast and accurate fullyautomated particle picker for cryo-EM. Communications Biology
doi: ttps://

Tanaka Y, Kato S, Stabrin M, Raunser S, Matsui T, Gatsogiannis C (2019). Cryo-EM reveals the asymmetric assembly of squid hemocyanin. IUCrJ
doi: 10.1107/S205225251900321X.


Saha, S.; Holzapfel, B.; Chen, Y.-T.; Terlinden, K.; Lill, P.; Gatsogiannis, C.; Rehage, H.; Clever, G. H.:
Rational Design of an Amphiphilic Coordination Cage-Based Emulsifier. Journal of the American Chemical Society 140 (50), pp. 17384 - 17388 (2018)

Vinayagam D, Mager T, Apelbaum A, Bothe A, Merino F, Hofnagel O, Gatsogiannis C, Raunser S (2018). Electron cryo-microscopy structure of the canonical TRPC4 ion channel. eLife
doi: 10.7554/eLife.36615.

Kato S, Matsui T, Gatsogiannis C, Tanaka Y (2018). Molluscan hemocyanin: structure, evolution, and physiology. Biophysical Reviews 10(2):191-202
doi: 10.1007/s12551-017-0349-4.


Chen M, Kato K, Kubo Y, Tanaka Y, Liu Y, Long F, Whitman WB, Lill P, Gatsogiannis C, Raunser S, Shimizu N, Shinoda A, Nakamura A, Tanaka I, Yao M (2017). Structural basis for tRNA-dependent cysteine biosynthesis. Nature Communications 8(1):1521.
doi: 10.1038/s41467-017-01543-y.

Pfeifer W, Lill P, Gatsogiannis C, Saccà B (2017). Hierarchical Assembly of DNA Filaments with Designer Elastic Properties. ACS Nano. 12(1):44-55.
doi: 10.1021/acsnano.7b06012.

Efremov RG, Gatsogiannis C, Raunser S (2017). Lipid Nanodiscs as a Tool for High-Resolution Structure Determination of Membrane Proteins by Single-Particle Cryo-EM. Methods in Enzymology

Moriya T, Saur M, Stabrin M, Merino F, Voicu H, Huang Z, Penczek PA, Raunser S, Gatsogiannis C (2017). High-resolution Single Particle Analysis from Electron Cryo-microscopy Images Using SPHIRE. J Vis Exp
doi: 10.3791/55448.

Sprengel A, Lill P, Stegemann P, Bravo-Rodriguez K, Schöneweiß EC, Merdanovic M, Gudnason D, Aznauryan M, Gamrad L, Barcikowski S, Sanchez-Garcia E, Birkedal V, Gatsogiannis C, Ehrmann M, Saccà B (2017). Tailored protein encapsulation into a DNA host using geometrically organized supramolecular interactions. Nature Communications 8:14472.
doi: 10.1038/ncomms14472.


Gatsogiannis C, Merino F, Prumbaum D, Roderer D,Leidreiter, Meusch D, Raunser S. Membrane insertion of a Tc toxin in near-atomic detail (2016). Tailored protein encapsulation into a DNA host using geometrically organized supramolecular interactions. Nature Structural Molecular Biology 23(10):884-890.
doi: 10.1038/nsmb.3281.


Poepsel S, Sprengel A, Sacca B, Kaschani F, Kaiser M, Gatsogiannis C, Raunser S, Clausen T, Ehrmann M (2015). Determinants of amyloid fibril degradation by the PDZ protease HTRA1. Nature Chemical Biology 11 (11), S. 862-869.
doi: 10.1038/nchembio.1931
freely available!

Raunser S, Gatsogiannis C (2015). Deciphering the Tubulin Code. Cell 161 (5), S. 960-961.
doi: 10.1016/j.cell.2015.05.004

Gatsogiannis C, Hofnagel O, Markl J, Raunser S (2015). Structure of Mega-Hemocyanin Reveals Protein Origami in Snails. Structure 23 (1), S. 93-103.
doi: 10.1016/j.str.2014.10.013


Meusch D, Gatsogiannis C, Efremov R, Lang A, Hofnagel O, Vetter I, Aktories K, Raunser S (2014). Mechanism of Tc toxin action revealed in molecular detail. Nature 508(7494):61-5.
doi: 10.1038/nature13015
freely available!

Erkelenz M, Bauer DM, Meyer R, Gatsogiannis C, Raunser S, Saccà B, Niemeyer CM (2014). A facile method for preparation of tailored scaffolds for DNA-origami. Small 15;10(1):73-7
doi: 10.1002/smll.201300701
freely available!


Sadian Y, Gatsogiannis C, Patasi C, Hofnagel O, Goody RS, Farkasovský M, Raunser S (2013). The role of Cdc42 and Gic1 in the regulation of septin filament formation and dissociation. eLife 2, e01085:1 - e01085:26.
doi: 10.7554/eLife.01085

Gatsogiannis C, Lang A, Meusch D, Pfaumann V, Hofnagel O, Benz R, Aktories K, Raunser S (2013). A syringe-like injection mechanism in Photorhabdus luminescens toxins. Nature. 495(7442):520-23
doi: 10.1038/nature11987
freely available!


Bröcker C, Kuhlee A, Gatsogiannis C, kleine Balderhaar HJ, Hönscher C, Engelbrecht-Vandré S, Ungermann C, Raunser S (2012). Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex. PNAS 109 (6), S. 1991-1996.
doi: 10.1073/pnas.1117797109


Lieb B, Gebauer W, Gatsogiannis C, Depoix F, Hellmann N, Harasewych MG, Strong EE, Markl J (2010). Molluscan mega-hemocyanin: an ancient oxygen carrier tuned by a ~550 kDa polypeptide. Frontiers in Zoology 109 (6), S. 1991-1996.
doi: 10.1186/1742-9994-7-14.


Gatsogiannis C, Markl J (2009). Keyhole limpet hemocyanin: 9-A CryoEM structure and molecular model of the KLH1 didecamer reveal the interfaces and intricate topology of the 160 functional units. Journal of Molecular Biology 385(3):963-83.
doi: 10.1016/j.jmb.2008.10.080.


Gatsogiannis C, Moeller A, Depoix F, Meissner U, Markl J (2007). Nautilus pompilius hemocyanin: 9 A cryo-EM structure and molecular model reveal the subunit pathway and the interfaces between the 70 functional units. Journal of Molecular Biology 374(2):465-86.
doi: 10.1186/1742-9994-7-14.

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