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Publications

1.
Kapoor, S.; Waldmann, H.; Ziegler, S.:
Novel approaches to map small molecule–target interactions
2.
Danda, A.; Naredla, K. R.; Golz, C.; Strohmann, C.; Kumar, K.:
Asymmetric Roadmap to Diverse Polycyclic Benzopyrans via Phosphine-Catalyzed Enantioselective [4 + 2]-Annulation Reaction.

3.
Kötzner, L.; Leutzsch, M.; Sievers, S.; Patil, S.; Waldmann, H.; Zheng, Y.; Thiel, W.; List, B.
The Organocatalytic Approach to Enantiopure 2H- and 3H-Pyrroles: Inhibitors of the Hedgehog Signaling Pathway
4.
Xu, H.; Golz, C.; Strohmann, C.; Antonchick, A. P.; Waldmann, H.
Enantiodivergent Combination of Natural Product Scaffolds Enabled by Catalytic Enantioselective Cycloaddition
5.
Papke B, Murarka S, Vogel HA, Martín-Gago P, Kovacevic M, Truxius D, Fansa EK, Ismail S, Zimmermann G, Heinelt K, Schultz-Fademrecht C, Saabi AA, Baumann M, Nussbaumer P, Wittinghofer A, Waldmann H, Bastiaens PIH.  

Identification of pyrazolopyridazinones as PDEδ inhibitors

Events

 
 

Cells are the universal thread of biological matter, and their division is of outmost importance for organismal development and for the propagation of life across generations. The reductional division of cells, known as meiosis, gives rise to gametes, whose encounter restores the genetic content (ploidy) of organisms. The equational division of cells, known as mitosis, provides the daughter cells with faithful copies of the genome. Both process are accurate and closely regulated. Our laboratory studies the molecular mechanisms of cell division, their regulation, and their deregulation in the most common disease of cell division, cancerous transformation.

Prof. Dr. Andrea Musacchio
Department of Mechanistic Cell Biology

Cells are the universal thread of biological matter, and their division is of outmost importance for organismal development and for the propagation of life across generations. The reductional division of cells, known as meiosis, gives rise to gametes, whose encounter restores the genetic content (ploidy) of organisms. The equational division of cells, known as mitosis, provides the daughter cells with faithful copies of the genome. Both process are accurate and closely regulated. Our laboratory studies the molecular mechanisms of cell division, their regulation, and their deregulation in the most common disease of cell division, cancerous transformation. [more]
When scientists finished mapping the human genome in 2001, they were in for quite a surprise: Instead of the 80,000 to 130,000 genes that were expected, Homo sapiens has only 20,000 to 30,000 – about the same number as a mouse and just barely more than a simple one-millimetre-long worm with hardly any brain at all.

Prof. Dr. Philippe Bastiaens
Department of Systemic Cell Biology

When scientists finished mapping the human genome in 2001, they were in for quite a surprise: Instead of the 80,000 to 130,000 genes that were expected, Homo sapiens has only 20,000 to 30,000 – about the same number as a mouse and just barely more than a simple one-millimetre-long worm with hardly any brain at all. [more]
The plan sounded impressive, and garnering plenty of new inexpensive drugs appeared a sure thing. With the advent of synthesis robots at the beginning of the 1990s, the pharma industry could produce thousands of different small molecules in almost no time, and a veritable boom in substance research seemed in the offing.

Prof. Dr. Dr. h.c. Herbert Waldmann
Department of Chemical Biology

The plan sounded impressive, and garnering plenty of new inexpensive drugs appeared a sure thing. With the advent of synthesis robots at the beginning of the 1990s, the pharma industry could produce thousands of different small molecules in almost no time, and a veritable boom in substance research seemed in the offing. [more]
 
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