Next application round starts 7th December 2016
September 09, 2016
July 21, 2016
July 11, 2016
March 17, 2015
December 02, 2014
April 10, 2014
Membrane insertion of a Tc toxin in near-atomic detail
Nature Structural and Molecular Biology, S. 1-10 (2016)
bMERB domains are bivalent Rab8 family effectors evolved by gene duplication
eLife, e18675:1-e18675:49 (2016)
Building polycyclic indole scaffolds via gold(I)-catalyzed intra- and inter-molecular cyclization reactions of 1,6-enynes
Tetrahedron 72(26), S. 3647-3652 (2016)
Reversible cryo-arrest for imaging molecules in living cells at high spatial resolution
Nature methods 13(8), S. 665-672 (2016)
Insights from biochemical reconstitution into the architecture of human kinetochores
Cells are the universal thread of biological matter, and their division is of outmost importance for organismal development and for the propagation of life across generations. The reductional division of cells, known as meiosis, gives rise to gametes, whose encounter restores the genetic content (ploidy) of organisms. The equational division of cells, known as mitosis, provides the daughter cells with faithful copies of the genome. Both process are accurate and closely regulated. Our laboratory studies the molecular mechanisms of cell division, their regulation, and their deregulation in the most common disease of cell division, cancerous transformation.
When scientists finished mapping the human genome in 2001, they were in for quite a surprise: Instead of the 80,000 to 130,000 genes that were expected, Homo sapiens has only 20,000 to 30,000 – about the same number as a mouse and just barely more than a simple one-millimetre-long worm with hardly any brain at all.
The plan sounded impressive, and garnering plenty of new inexpensive drugs appeared a sure thing. With the advent of synthesis robots at the beginning of the 1990s, the pharma industry could produce thousands of different small molecules in almost no time, and a veritable boom in substance research seemed in the offing.