andrea musacchio

Mechanistic Cell Biology

Phone:+49 (231) 133-2100


Antje Peukert
Phone: +49 (231) - 133 2101
Fax: +49 (231) - 133 2199

Weith M, Seiler J, van den Boom J, Kracht M, Hülsmann J, Primorac I, Del Pino Garcia J, Kaschani F, Kaiser M, Musacchio A, Bollen M, Meyer H (2018). Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation. Mol Cell
doi: 10.1016/j.molcel.2018.09.020.

Pesenti ME, Prumbaum D, Auckland P, Smith CM, Faesen AC, Petrovic A, Erent M, Maffini S, Pentakota S, Weir JR, Lin YC, Raunser S, McAinsh AD, Musacchio A (2018). Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80. Mol Cell
doi: 10.1016/j.molcel.2018.07.038.

Pan D, Brockmeyer A, Mueller F, Musacchio A, Bange T (2018). Simplified Protocol for Cross-linking Mass Spectrometry Using the MS-Cleavable Cross-linker DSBU with Efficient Cross-link Identification. Anal Chem
doi: 10.1021/acs.analchem.8b02593

Sacristan C, Ahmad MUD, Keller J, Fermie J, Groenewold V, Tromer E, Fish A, Melero R, Carazo JM, Klumperman J, Musacchio A, Perrakis A, Kops GJ. (2018). Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis. Nat Cell Biol
doi: 10.1038/s41556-018-0130-3.

Ciossani G, Overlack K, Petrovic A, Huis In 't Veld PJ, Koerner C, Wohlgemuth S, Maffini S, Musacchio A (2018). The kinetochore proteins CENP-E and CENP-F directly and specifically interact with distinct BUB mitotic checkpoint Ser/Thr kinases. J Biol Chem
doi: 10.1074/jbc.RA118.003154.

Volkov VA, Huis In 't Veld PJ, Dogterom M, Musacchio A. (2018). Multivalency of NDC80 in the outer kinetochore is essential to track shortening microtubules and generate forces. eLife
doi: 10.7554/eLife.36764


Pentakota S, Zhou K, Smith C, Maffini S, Petrovic A, Morgan GP, Weir JR, Vetter IR, Musacchio A, Luger K (2017). Decoding the centromeric nucleosome through CENP-N. eLife
doi: 10.7554/eLife.33442.

Overlack K, Bange T, Weissmann F, Faesen AC, Maffini S, Primorac I, Müller F, Peters JM, Musacchio A (2017). BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint Signaling. Curr Biol
doi: 10.1016/j.cub.2017.08.033.

Mosalaganti S, Keller J, Altenfeld A, Winzker M, Rombaut P, Saur M, Petrovic A, Wehenkel A, Wohlgemuth S, Müller F, Maffini S, Bange T, Herzog F, Waldmann H, Raunser S & Musacchio A (2017). Structure of the RZZ complex and molecular basis of its interaction with Spindly. J Cell Bio 216(4):961-981
doi: 10.1083/jcb.201611060.

Musacchio A, Desai A (2017). A Molecular View of Kinetochore Assembly and Function Biology (Basel) 6(1). pii: E5.
doi: doi: 10.3390/biology6010005.

Faesen AC, Thanasoula M, Maffini S, Breit C, Müller F, van Gerwen S, Bange T, Musacchio A (2017). Basis of catalytic assembly of the mitotic checkpoint complex. Nature
doi: 10.1038/nature21384.

Pan D, Klare K, Petrovic A, Take A, Walstein K, Singh P, Rondelet A, Bird AW, Musacchio A (2017). CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading. eLife 6:e23352.
doi: 10.7554/eLife.23352.


Huis In 't Veld PJ, Jeganathan S, Petrovic A, Singh P, John J, Krenn V, Weissmann F, Bange T, Musacchio A (2016). Molecular basis of outer kinetochore assembly on CENP-T. eLife 5:e21007.
doi: 10.7554/eLife.21007.

Petrovic A, Keller J, Liu Y, Overlack K, John J, Dimitrova YN, Jenni S, van Gerwen S, Stege P, Wohlgemuth S, Rombaut P, Herzog F, Harrison SC, Vetter IR, and Musacchio A (2016). Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores. Cell 167(4):1028-1040.e15.

Weir JR, Faesen AC, Klare K, Petrovic A, Basilico F, Fischböck J, Pentakota S, Keller J, Pesenti ME, Pan D, Vogt D, Wohlgemuth S, Herzog F, Musacchio A (2016). Insights from biochemical reconstitution into the architecture of human kinetochores. Nature 537(7619):249-253.
doi: 10.1038/nature19333.

Borisy G, Heald R, Howard J, Janke C, Musacchio A, Nogales E (2016). Microtubules: 50 years on from the discovery of tubulin. Nat Rev Mol Cell Biol. (5):322-8.
doi: 10.1038/nrm.2016.45.

Friese A, Faesen AC, Huis in 't Veld PJ, Fischböck J, Prumbaum D, Petrovic A, Raunser S, Herzog F, Musacchio A (2016). Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and Astrin. Nat Commun 7:11407.
doi: 10.1038/ncomms11407.

Pesenti ME, Weir JR, Musacchio A (2016). Progress in the structural and functional characterization of kinetochores. Curr Opin Struct 37:152-63. doi: 10.1016/
doi: 10.1038/nature19333.

Liu Y, Petrovic A, Rombaut P, Mosalaganti S, Keller J, Raunser S, Herzog F, Musacchio A (2016)..Insights from the reconstitution of the divergent outer kinetochore of Drosophila melanogaster. Open Biol 150236.
doi: 10.1098/rsob.150236.


O'Connor A, Maffini S, Rainey MD, Kaczmarczyk A, Gaboriau D, Musacchio A, Santocanale C (2015). Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint. Biol Open 5(1):11-9. doi: 10.1242/bio.014969.
doi: 10.1242/bio.014969.

Musacchio A (2015). The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics. Curr Biol 25(20):R1002-18.
doi: 10.1016/j.cub.2015.08.051.

Klare K, Weir JR, Basilico F, Zimniak T, Massimiliano L, Ludwigs N, Herzog F, Musacchio A (2015). CENP-C is a blueprint for constitutive centromere-associated network assembly within human kinetochores. J Cell Biol 210(1):11-22.
doi: 10.1083/jcb.201412028.

Meyer R, Faesen A, Vogel K, Jeganathan S, Musacchio A, Niemeyer CM (2015). DNA-Directed Assembly of Capture Tools for Constitutional Studies of Large Protein Complexes. Small11(22):2669-74. doi: 10.1002/smll.201403544.
doi: 10.1002/smll.201403544.

Musacchio A (2015). Closing the Mad2 cycle. Elife
doi: 10.7554/eLife.08283.

Tachiwana H, Müller S, Blümer J, Klare K, Musacchio A, Almouzni G (2015). HJURP involvement in de novo CenH3(CENP-A) and CENP-C recruitment. Cell Rep 11(1):22-32.
doi: 10.1016/j.celrep.2015.03.013.

Altenfeld A, Wohlgemuth S, Wehenkel A, Vetter IR, Musacchio A (2015). Complex assembly, crystallization and preliminary X-ray crystallographic analysis of the human Rod-Zwilch-ZW10 (RZZ) complex. Acta Crystallogr F Struct Biol Commun 71(Pt 4):438-42.
doi: 10.1107/S2053230X15004343.

Faesen AC, Musacchio A (2015). The (phospho) needle in the (MELT) Haystack. Mol Cell 57(5):765-6.
doi: 10.1016/j.molcel.2015.02.026.

Overlack K, Primorac I, Vleugel M, Krenn V, Maffini S, Hoffmann I, Kops GJ, Musacchio A (2015). A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint. Elife 4:e05269.
doi: 10.7554/eLife.05269.

Krenn V, Musacchio A (2015). The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling. Front Oncol 5:225.
doi: 10.3389/fonc.2015.00225.

Breit C, Bange T, Petrovic A, Weir JR, Müller F, Vogt D, Musacchio A (2015). Role of Intrinsic and Extrinsic Factors in the Regulation of the Mitotic Checkpoint Kinase Bub1. PLoS One 10(12):e0144673.
doi: 10.1371/journal.pone.0144673.


Vader G, Musacchio A (2014). HORMA domains at the heart of meiotic chromosome dynamics. Dev Cell 31(4):389-91.
doi: 10.1016/j.devcel.2014.11.009.

Eiteneuer A, Seiler J, Weith M, Beullens M, Lesage B, Krenn V, Musacchio A, Bollen M, Meyer H (2014). Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1. EMBO J33(22):2704-20. doi: 10.15252/embj.201489054.

Basilico F, Maffini S, Weir JR, Prumbaum D, Rojas AM, Zimniak T, De Antoni A, Jeganathan S, Voss B, van Gerwen S, Krenn V, Massimiliano L, Valencia A, Vetter IR, Herzog F, Raunser S, Pasqualato S & Musacchio A (2014). The pseudo GTPase CENP-M drives human kinetochore assembly. Elife 8:e02978.
doi: 10.7554/eLife.02978

Overlack K, Krenn V, Musacchio A (2014). When Mad met Bub. EMBO Rep 15(4):326-8.
doi: 10.1002/embr.201438574.

Petrovic A, Mosalaganti S, Keller J, Mattiuzzo M, Overlack K, Krenn V, De Antoni A, Wohlgemuth S, Cecatiello V, Pasqualato S, Raunser S, Musacchio A (2014). Modular assembly of RWD domains on the Mis12 complex underlies outer kinetochore organization. Mol Cell 53(4):591-605.
doi: 10.1016/j.molcel.2014.01.019.

Krenn V, Overlack K, Primorac I, van Gerwen S, Musacchio A (2014). KI motifs of human Knl1 enhance assembly of comprehensive spindle checkpoint complexes around MELT repeats. Curr Biol24(1):29-39.
doi: 10.1016/j.cub.2013.11.046.


Musacchio A, Helin K (2013). Cell cycle, differentiation and disease. Curr Opin Cell Biol 25(6):673-5.
doi: 10.1016/

Primorac I, Weir JR, Chiroli E, Gross F, Hoffmann I, van Gerwen S, Ciliberto A, Musacchio A (2013). Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling. Elife 2:e01030. doi: 10.7554/eLife.01030.
doi: 10.7554/eLife.01030.

Primorac I, Musacchio A (2013). Panta rhei: the APC/C at steady state. J Cell Biol201(2):177-89.
doi: 10.1083/jcb.201301130.

Musacchio A, Ciliberto A (2013). The spindle-assembly checkpoint and the beauty of self-destruction. Nat Struct Mol Biol 19(11):1059-61. Erratum in: Nat Struct Mol Biol. 2013 Feb;20(2):244.
doi: 10.1038/nsmb.2429.


Mariani L, Chiroli E, Nezi L, Muller H, Piatti S, Musacchio A, Ciliberto A (2012). Role of the Mad2 dimerization interface in the spindle assembly checkpoint independent of kinetochores. Curr Biol 22(20):1900-8.
doi: 10.1016/j.cub.2012.08.028.

De Antoni A, Maffini S, Knapp S, Musacchio A, Santaguida S (2012). A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B. J Cell Biol 199(2):269-84.
doi: 10.1083/jcb.201205119.

Elkins JM, Santaguida S, Musacchio A, Knapp S (2012). Crystal structure of human aurora B in complex with INCENP and VX-680. J Med Chem 55(17):7841-8.
doi: 10.1021/jm3008954.

Musacchio A (2012). Andrea Musacchio. Curr Biol 22(14):R552-4.

Krenn V, Wehenkel A, Li X, Santaguida S, Musacchio A (2012). Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction. J Cell Biol 196(4):451-67.
doi: 10.1083/jcb.201110013.

DeLuca JG, Musacchio A (2012). Structural organization of the kinetochore-microtubule interface. Curr Opin Cell Biol 24(1):48-56.
doi: 10.1016/

Kwiatkowski N, Deng X, Wang J, Tan L, Villa F, Santaguida S, Huang HC, Mitchison T, Musacchio A, Gray N (2012). Selective aurora kinase inhibitors identified using a taxol-induced checkpoint sensitivity screen. ACS Chem Biol 7(1):185-96.
doi: 10.1021/cb200305u.


Musacchio A (2011). Spindle assembly checkpoint: the third decade. Philos Trans R Soc Lond B Biol Sci 366(1584):3595-604. doi: 10.1098/rstb.2011.0072.

Varetti G, Guida C, Santaguida S, Chiroli E, Musacchio A (2011). Homeostatic control of mitotic arrest. Mol Cell 44(5):710-20.
doi: 10.1016/j.molcel.2011.11.014.

Balzano D, Santaguida S, Musacchio A, Villa F (2011). A general framework for inhibitor resistance in protein kinases. Chem Biol 18(8):966-75. Erratum in: Chem Biol. 2011 Oct 28;18(10):1341.
doi: 10.1016/j.chembiol.2011.04.013.

Musacchio A (2011). Travel notes from the equatorial circle. Cell 146(4):499-501. doi: 10.1016/j.cell.2011.08.001.

Perrakis A, Musacchio A, Cusack S, Petosa C (2011). Investigating a macromolecular complex: the toolkit of methods. J Struct Biol 175(2):106-12.
doi: 10.1016/j.jsb.2011.05.014.

Abrahams JP, Apweiler R, Balling R, Bertero MG, Bujnicki JM, Chayen NE, Chène P, Corthals GL, Dyląg T, Förster F, Heck AJ, Henderson PJ, Herwig R, Jehenson P, Kokalj SJ, Laue E, Legrain P, Martens L, Migliorini C, Musacchio A, Podobnik M, Schertler GF, Schreiber G, Sixma TK, Smit AB, Stuart D, Svergun DI, Taussig MJ (2011). "4D Biology for health and disease" workshop report. N Biotechnol 28(4):291-3.
doi: 10.1016/j.nbt.2010.10.003.

Alexander J, Lim D, Joughin BA, Hegemann B, Hutchins JR, Ehrenberger T, Ivins F, Sessa F, Hudecz O, Nigg EA, Fry AM, Musacchio A, Stukenberg PT, Mechtler K, Peters JM, Smerdon SJ, Yaffe MB (2011). Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling. Sci Signal 4(179):ra42.
doi: 10.1126/scisignal.2001796.

Santaguida S, Vernieri C, Villa F, Ciliberto A, Musacchio A (2011). Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction. EMBO J 30(8):1508-19.
doi: 10.1038/emboj.2011.70..

Maspero E, Mari S, Valentini E, Musacchio A, Fish A, Pasqualato S, Polo S (2011). Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation. EMBO 12(4):342-9. doi: 10.1038/embor.2011.21.
doi: 10.1038/embor.2011.21

Screpanti E, De Antoni A, Alushin GM, Petrovic A, Melis T, Nogales E, Musacchio A (2011). Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore. Curr Biol 21(5):391-8. doi: 10.1016/j.cub.2010.12.039.
doi: 10.1016/j.cub.2010.12.039.

Maure JF, Komoto S, Oku Y, Mino A, Pasqualato S, Natsume K, Clayton L, Musacchio A, Tanaka TU (2011). The Ndc80 loop region facilitates formation of kinetochore attachment to the dynamic microtubule plus end. Curr Biol 21(3):207-13. doi: 10.1016/j.cub.2010.12.050.
doi: 10.1016/j.cub.2010.12.050.

Mattiuzzo M, Vargiu G, Totta P, Fiore M, Ciferri C, Musacchio A, Degrassi F (2011). Abnormal kinetochore-generated pulling forces from expressing a N-terminally modified Hec1. PLoS One 6(1):e16307.
doi: 10.1371/journal.pone.0016307.

Before 2011

Alushin GM, Ramey VH, Pasqualato S, Ball DA, Grigorieff N, Musacchio A, Nogales E (2010). The Ndc80 kinetochore complex forms oligomeric arrays along microtubules. Nature. 2010 467(7317):805-10.
doi: 10.1038/nature09423.

Musacchio A (2010). Molecular biology. Surfing chromosomes (and Survivin). Science183-4.
doi: 10.1126/science.1197261.

Petrovic A, Pasqualato S, Dube P, Krenn V, Santaguida S, Cittaro D, Monzani S, Massimiliano L, Keller J, Tarricone A, Maiolica A, Stark H, Musacchio A (2010). The MIS12 complex is a protein interaction hub for outer kinetochore assembly. J Cell Biol 190(5):835-52.
doi: 10.1083/jcb.201002070.

Musacchio A (2010). Cell cycle: deconstructing tension. Curr Biol 20(15):R634-7.
doi: 10.1016/j.cub.2010.06.014.

Screpanti E, Santaguida S, Nguyen T, Silvestri R, Gussio R, Musacchio A, Hamel E, De Wulf P (2010). A screen for kinetochore-microtubule interaction inhibitors identifies novel antitubulin compounds. PLoS One5(7):e11603.
doi: 10.1371/journal.pone.0011603.

Santaguida S, Tighe A, D'Alise AM, Taylor SS, Musacchio A (2010). Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine. J Cell Biol190(1):73-87.
doi: 10.1083/jcb.201001036.

Hewitt L, Tighe A, Santaguida S, White AM, Jones CD, Musacchio A, Green S, Taylor SS (2010).Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex. J Cell Biol190(1):25-34. doi: 10.1083/jcb.201002133.
doi: 10.1083/jcb.201002133.

Civril F, Wehenkel A, Giorgi FM, Santaguida S, Di Fonzo A, Grigorean G, Ciccarelli FD, Musacchio A (2010). Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery. Structure 8(5):616-26. doi: 10.1016/j.str.2010.02.014.

Nezi L, Musacchio A (2009). Sister chromatid tension and the spindle assembly checkpoint. Curr Opin Cell Biol 21(6):785-95.
doi: 10.1016/

Villa F, Capasso P, Tortorici M, Forneris F, de Marco A, Mattevi A, Musacchio A (2009). Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organization. Proc Natl Acad Sci U S A 106(48):20204-9.
doi: 10.1073/pnas.0908485106 .

Santaguida S, Musacchio A (2009). The life and miracles of kinetochores. EMBO J 28(17):2511-31.
doi: 10.1038/emboj.2009.173.

Trazzi S, Perini G, Bernardoni R, Zoli M, Reese JC, Musacchio A, Della Valle G (2009). The C-terminal domain of CENP-C displays multiple and critical functions for mammalian centromere formation. PLoS One 4(6):e5832.
doi: 10.1371/journal.pone.0005832.

DeMoe JH, Santaguida S, Daum JR, Musacchio A, Gorbsky GJ (2009). A high throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel Aurora kinase inhibitor. Cancer Res 69(4):1509-16.
doi: 10.1158/0008-5472.CAN-08-3133.

Simonetta M, Manzoni R, Mosca R, Mapelli M, Massimiliano L, Vink M, Novak B, Musacchio A, Ciliberto A (2009). The influence of catalysis on mad2 activation dynamics. PLoS Biol 7(1):e10. doi: 10.1371/journal.pbio.1000010.
doi: 10.1371/journal.pbio.1000010.

Civril F, Musacchio A (2008). Spindly attachments. Genes Dev22(17):2302-7.
doi: 10.1101/gad.1719208.

Varetti G, Musacchio A (2008). The spindle assembly checkpoint. Curr Biol 18(14):R591-5. Erratum in: Curr Biol. 2008 Sep 23;18(18):1444.
doi: 10.1016/j.cub.2008.06.012..

Girdler F, Sessa F, Patercoli S, Villa F, Musacchio A, Taylor S (2008). Molecular basis of drug resistance in aurora kinases. Chem Biol 15(6):552-62.
doi: 10.1016/j.chembiol.2008.04.013.

Ciferri C, Pasqualato S, Screpanti E, Varetti G, Santaguida S, Dos Reis G, Maiolica A, Polka J, De Luca JG, De Wulf P, Salek M, Rappsilber J, Moores CA, Salmon ED, Musacchio A (2008). Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex. Cell 133(3):427-39.
doi: 10.1016/j.cell.2008.03.020.

D'Alise AM, Amabile G, Iovino M, Di Giorgio FP, Bartiromo M, Sessa F, Villa F, Musacchio A, Cortese R (2008). Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells.<í> Mol Cancer Ther 7(5):1140-9.
doi: 10.1158/1535-7163.MCT-07-2051.

Andersen CB, Wan Y, Chang JW, Riggs B, Lee C, Liu Y, Sessa F, Villa F, Kwiatkowski N, Suzuki M, Nallan L, Heald R, Musacchio A, Gray NS (2008). Discovery of selective aminothiazole aurora kinase inhibitors. ACS Chem Bioll 3(3):180-92.
doi: 10.1021/cb700200w.

Mapelli M, Musacchio A (2007). MAD contortions: conformational dimerization boosts spindle checkpoint signaling. Curr Opin Struct Biol Dec;17(6):716-25.

Maiolica A, Cittaro D, Borsotti D, Sennels L, Ciferri C, Tarricone C, Musacchio A, Rappsilber J (2007. Structural analysis of multiprotein complexes by cross-linking, mass spectrometry, and database searching. Mol Cell Proteomics 6(12):2200-11.

Mapelli M, Massimiliano L, Santaguida S, Musacchio A (2007). The Mad2 conformational dimer: structure and implications for the spindle assembly checkpoint. Cell 131(4):730-43.

Derewenda U, Tarricone C, Choi WC, Cooper DR, Lukasik S, Perrina F, Tripathy A, Kim MH, Cafiso DS, Musacchio A, Derewenda ZS (2007). The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly. Structure 15(11):1467-81.

Ciferri C, Musacchio A, Petrovic A (2007). The Ndc80 complex: hub of kinetochore activity. FEBS Lett 581(15):2862-9.

Taylor SS, Hardwick KG, Sawin KE, Biggins S, Piatti S, Khodjakov A, Rieder CL, Salmon ED, Musacchio A (2007). Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint". Science 316(5827):982; author reply 982.

Musacchio A, Salmon ED (2007). The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol (5):379-93.
doi: 10.1038/nrm2163

Plyte S, Musacchio A (2007). PLK1 inhibitors: setting the mitotic death trap. Curr Biol 17(8):R280-3.

DeLuca JG, Gall WE, Ciferri C, Cimini D, Musacchio A, Salmon ED (2006). Kinetochore microtubule dynamics and attachment stability are regulated by Hec1.Cell127(5):969-82.

Nezi L, Rancati G, De Antoni A, Pasqualato S, Piatti S, Musacchio A (2006). Accumulation of Mad2-Cdc20 complex during spindle checkpoint activation requires binding of open and closed conformers of Mad2 in Saccharomyces cerevisiae. J Cell Biol174(1):39-51.

Vink M, Simonetta M, Transidico P, Ferrari K, Mapelli M, De Antoni A, Massimiliano L, Ciliberto A, Faretta M, Salmon ED, Musacchio A (2006). In vitro FRAP identifies the minimal requirements for Mad2 kinetochore dynamics. Curr Biol 16(8):755-66.

Penengo L, Mapelli M, Murachelli AG, Confalonieri S, Magri L, Musacchio A, Di Fiore PP, Polo S, Schneider TR (2006). Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin. Cell 124(6):1183-95.

Mapelli M, Filipp FV, Rancati G, Massimiliano L, Nezi L, Stier G, Hagan RS, Confalonieri S, Piatti S, Sattler M, Musacchio A (2006). Determinants of conformational dimerization of Mad2 and its inhibition by p31comet. EMBO J 25(6):1273-84.

Mesngon MT, Tarricone C, Hebbar S, Guillotte AM, Schmitt EW, Lanier L, Musacchio A, King SJ, Smith DS (2006). Regulation of cytoplasmic dynein ATPase by Lis1. J Neurosci 26(7):2132-9.

Ciferri C, De Luca J, Monzani S, Ferrari KJ, Ristic D, Wyman C, Stark H, Kilmartin J, Salmon ED, Musacchio A (2005). Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore. J Biol Chem 280(32):29088-95.
doi: 10.1074/jbc.M504070200

Ahn JS, Radhakrishnan ML, Mapelli M, Choi S, Tidor B, Cuny GD, Musacchio A, Yeh LA, Kosik KS (2005). Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation. Chem Biol 12(7):811-23.

Lacy ER, Wang Y, Post J, Nourse A, Webb W, Mapelli M, Musacchio A, Siuzdak G, Kriwacki RW (2005). Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division. J Mol Biol 349(4):764-73.

  Sessa F, Mapelli M, Ciferri C, Tarricone C, Areces LB, Schneider TR, Stukenberg PT, Musacchio A (2005). Mechanism of Aurora B activation by INCENP and inhibition by hesperadin. Mol Cell 18(3):379-91.

DeAntoni A, Sala V, Musacchio A (2005). Explaining the oligomerization properties of the spindle assembly checkpoint protein Mad2. Philos Trans R Soc Lond B Biol Sci 360(1455):637-47, discussion 447-8.
doi: 10.1098/rstb.2004.1618

Mapelli M, Massimiliano L, Crovace C, Seeliger MA, Tsai LH, Meijer L, Musacchio A (2005). Mechanism of CDK5/p25 binding by CDK inhibitors. J Med Chem 48(3):671-9.

De Antoni A, Pearson CG, Cimini D, Canman JC, Sala V, Nezi L, Mapelli M, Sironi L, Faretta M, Salmon ED, Musacchio A (2005). The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint. Curr Biol 15(3):214-25.

Tarricone C, Perrina F, Monzani S, Massimiliano L, Kim MH, Derewenda ZS, Knapp S, Tsai LH, Musacchio A (2004). Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase. Neuron 44(5):809-21.

Steensgaard P, Garrè M, Muradore I, Transidico P, Nigg EA, Kitagawa K, Earnshaw WC, Faretta M, Musacchio A (2004). Sgt1 is required for human kinetochore assembly. EMBO Rep 5(6):626-31. Epub 2004 May 7.
doi: 10.1038/sj.embor.7400154

Ahn JS, Musacchio A, Mapelli M, Ni J, Scinto L, Stein R, Kosik KS, Yeh LA (2004). Development of an assay to screen for inhibitors of tau phosphorylation by cdk5. J Biomol Screen 9(2):122-31.
doi: 10.1177/1087057103260594

Polychronopoulos P, Magiatis P, Skaltsounis AL, Myrianthopoulos V, Mikros E, Tarricone A, Musacchio A, Roe SM, Pearl L, Leost M, Greengard P, Meijer L (2004). Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J Med Chem 47(4):935-46.
doi: 10.1021/jm031016d

Meijer L, Skaltsounis AL, Magiatis P, Polychronopoulos P, Knockaert M, Leost M, Ryan XP, Vonica CA, Brivanlou A, Dajani R, Crovace C, Tarricone C, Musacchio A, Roe SM, Pearl L, Greengard P (2003). GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol 10(12):1255-66.

Mapelli M, Musacchio A (2003). The structural perspective on CDK5. Neurosignals 12(4-5):164-72.

Musacchio A, Hardwick KG (2002). The spindle checkpoint: structural insights into dynamic signalling. Nat Rev Mol Cell Biol 3(10):731-41.

Sironi L, Mapelli M, Knapp S, De Antoni A, Jeang KT, Musacchio A (2002). Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint. EMBO J21(10):2496-506.
doi: 10.1093/emboj/21.10.2496

Musacchio A (2002). How SH3 domains recognize proline. Adv Protein Chem 2002;61:211-68.

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