philippe bastiaens

Systemic Cell Biology

Phone:+49 (231) 133-2200


Secretary

Tanja Forck
Phone: +49 (231) - 133 2201
Fax: +49 (231) - 133 2299

Scientific Coordination

Astrid Krämer
Phone: +49 (231) - 133 2206 
Fax: +49 (231) - 133 2299

Research interests

Systemic Cell Biology >



Cognition emerges from the pattern forming activity of biochemical networks that execute cell signaling, and we are generally interested in how the dynamics of biochemical networks generate the spatial organization of signaling systems. Our attention is currently focused on the interdependence of membrane dynamics and early growth factor signal processing in cells. In this context, we investigate how the interaction of receptor tyrosine kinases (RTKs), small GTPases and Src family kinases with membrane systems affects the dynamics of signaling networks and thereby change the cell’s perception of the environment. Based on these studies, we opened new avenues for pharmacological interference with oncogenic signaling in cancer cells. We have also started a new synthetic biology research line in which we reconstitute from biochemical building blocks a trinity of signaling, cytoskeletal dynamics, and membrane shape that interact within a closed-loop causality to give rise to a self-organized morphogenic system.


Selected publications

PubMed Liste>



Zimmermann G, Papke B, Ismail S, Vartak N, Chandra A, Hoffmann M, Hahn SA, Triola G, Wittinghofer A, Bastiaens PI, Waldmann H (2013). Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature 30;497(7451):638-42
doi: 10.1038/nature12205.

Papke B, Murarka S, Vogel HA, Martín-Gago P, Kovacevic M, Truxius DC, Fansa EK, Ismail S, Zimmermann G, Heinelt K, Schultz-Fademrecht C, Al Saabi A, Baumann M, Nussbaumer P, Wittinghofer A, Waldmann H, Bastiaens PI (2016). Identification of pyrazolopyridazinones as PDEδ inhibitors. Nat Commun 7:11360. doi: 10.1038/ncomms11360.
doi: 10.1038/ncomms11360.

Schmick M, Vartak N, Papke B, Kovacevic M, Truxius DC, Rossmannek L, Bastiaens PI (2014). KRas localizes to the plasma membrane by spatial cycles of solubilization, trapping and vesicular transport. Cell 157(2):459-71.
doi: 10.1016/j.cell.2014.02.051.

Vartak N, Papke B, Grecco HE, Rossmannek L, Waldmann H, Hedberg C, Bastiaens PIH (2014). Autocatalytic APT depalmitoylation maintains spatial organization of palmitoylated membrane proteins. Biophys J 106(1):93-105
doi: 10.1016/j.bpj.2013.11.024.

Sabet O, Stockert R, Xouri G, Brüggemann Y, Stanoev A, Bastiaens PI (2015). Ubiquitination switches EphA2 vesicular traffic from a continuous safeguard to a finite signaling mode. Nat Commun 6:8047.
doi: 10.1038/ncomms9047.

Baumdick M, Brüggemann Y, Schmick M, Xouri G, Sabet O, Davis L, Chin JW, Bastiaens PI (2015). EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling. ELife 4: e12223.
doi: 10.7554/eLife.12223.

Roda-Navarro P, Bastiaens PI (2014). Dynamic recruitment of protein tyrosine phosphatase PTPD1 to EGF stimulation sites potentiates EGFR activation. PLoS One 9(7):e103203.
doi: 10.1371/journal.pone.0103203.

Ibach J, Radon Y, Gelleri M, Sonntag MH, Brunsveld L, Bastiaens PI, Verveer PJ (2015). Single Particle Tracking Reveals that EGFR Signaling Activity Is Amplified in Clathrin-Coated Pits. PLoS One 10(11):e0143162.
doi: 10.1371/journal.pone.0143162.

Masip ME, Huebinger J, Christmann J, Sabet O, Wehner F, Konitsiotis A, Fuhr GR, Bastiaens PI (2016). Reversible cryo-arrest for imaging molecules in living cells at high spatial resolution. Nat Methods. 13(8):665-72.
doi: 10.1038/nmeth.3921

 
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