Phone:+49 (231) 133-2300
Phone: +49 (231) - 133 2301
Fax: +49 (231) - 133 2399
Structural Biochemistry >
Our research concentrates on the molecular understanding of fundamental cellular processes. Firstly, we are interested in membrane homeostasis in eukaryotic cells and secondly we want to understand the molecular details of muscle contraction. Another focus is on the molecular understanding of the mechanism of action of bacterial toxin complexes.
Our overarching goal is to understand the mechanisms underlying these processes in the healthy and diseased organism in molecular detail. To achieve this, it is essential to elucidate the structure and thus the function of the involved proteins and protein complexes.
We perform structural analyses by single particle cryo-EM and X-ray crystallography, fluorescence-based assays and site-directed mutagenesis to determine the structures and functions of these complexes. For their biophysical characterization we employ isothermal titration calorimetry, ESI-MS, bio-layer interferometry, thermophoresis and CD spectroscopy.