Tc toxin activation requires unfolding and refolding of a β-propeller
Gatsogiannis C, Merino F, Roderer D, Balchin D, Schubert E, Kuhlee A, Hayer-Hartl M, Raunser S. (2018). Nature
Tc toxins that secrete toxic enzymes into host cells are composed of three subunits, TcA, TcB and TcC.
The Raunser lab in cooperation with the Hayer-Hartl lab from the MPI of Biochemistry in Martinsried now show in atomic detail how the assembly of the three components activates the toxin.
More information here: Gatekeeper for poison capsule