Tc toxin activation requires unfolding and refolding of a β-propeller

Gatsogiannis C, Merino F, Roderer D, Balchin D, Schubert E, Kuhlee A, Hayer-Hartl M, Raunser S. (2018). Nature 

doi: 10.1038/s41586-018-0556-6. 

Tc toxins that secrete toxic enzymes into host cells are composed of three subunits, TcA, TcB and TcC. The Raunser lab in cooperation with the Hayer-Hartl lab from the MPI of Biochemistry in Martinsried now show in atomic detail how the assembly of the three components activates the toxin.

More information here: Gatekeeper for poison capsule    
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