Ausgewählte Publikationen  2013 - 2025

Ausgewählte Publikationen  2013 - 2025

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2025

2024

Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53

Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53

Gersch Group. Nature Chemical Biology (2024) [mehr]
Regulation of minimal spindle midzone organization by mitotic kinases

Regulation of minimal spindle midzone organization by mitotic kinases

Musacchio Group. Nat Commun (2024) [mehr]
Stapled Peptides as Inhibitors of mRNA Deadenylation

Stapled Peptides as Inhibitors of mRNA Deadenylation

‘t Hart Group. Angew Chem Int Ed Engl. (2024) [mehr]
Phalloidin and DNase I-bound F-actin pointed end structures reveal principles of filament stabilization and disassembly

Phalloidin and DNase I-bound F-actin pointed end structures reveal principles of filament stabilization and disassembly

Bieleing & Raunser Group. Nat Commun (2024)  [mehr]
Role of protein kinase PLK1 in the epigenetic maintenance of centromeres

Role of protein kinase PLK1 in the epigenetic maintenance of centromeres

Musacchio Group. Science (2024) [mehr]
Stereoselective Entry into &alpha;,&alpha;&rsquo;-<em>C</em>-Oxepane Scaffolds through a Chalcogen Bonding Catalyzed Strain-Release&nbsp;<em>C</em>-Septanosylation Strategy

Stereoselective Entry into α,α’-C-Oxepane Scaffolds through a Chalcogen Bonding Catalyzed Strain-Release C-Septanosylation Strategy

Loh Group. Angew Chem Int Ed Engl. (2024)  [mehr]

2023

Exploiting &pi; and Chalcogen Interactions for the &beta;-Selective Glycosylation of Indoles through Glycal Conformational Distortion

Exploiting π and Chalcogen Interactions for the β-Selective Glycosylation of Indoles through Glycal Conformational Distortion

Loh Group. Angew Chem Ed Engl (2023) [mehr]
Structure and activation mechanism of the Makes caterpillars floppy 1 toxin

Structure and activation mechanism of the Makes caterpillars floppy 1 toxin

Raunser Group Nat Commun (2023) [mehr]
Cooperative Bifurcated Chalcogen Bonding and Hydrogen Bonding as Stereocontrolling Elements for Selective Strain-Release Septanosylation

Cooperative Bifurcated Chalcogen Bonding and Hydrogen Bonding as Stereocontrolling Elements for Selective Strain-Release Septanosylation

Loh Group. J. Am. Cehm. Soc. (2023) [mehr]
RZZ-Spindly and CENP-E form an integrated platform to recruit dynein to the kinetochore corona

RZZ-Spindly and CENP-E form an integrated platform to recruit dynein to the kinetochore corona

Musacchio Group. EMBO J (2023)  [mehr]
Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype

Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype

Waldmann Group. Nat Commun (2023)  [mehr]
Structure of the native myosin filament in the relaxed cardiac sarcomere

Structure of the native myosin filament in the relaxed cardiac sarcomere

Raunser Group. Nature (2023) [mehr]

2022

&nbsp;A synergistic Rh(I)/organoboron-catalysed site-selective carbohydrate functionalization that involves multiple stereocontrol

 A synergistic Rh(I)/organoboron-catalysed site-selective carbohydrate functionalization that involves multiple stereocontrol

Rao VUB, Wang C, Demarque DP, Grassin C, Otte F, Merten C, Strohmann C, Loh CCJ (2022) [mehr]
A cryogenic, coincident fluorescence, electron and ion beam microscope

A cryogenic, coincident fluorescence, electron and ion beam microscope

Boltje DB, Hoogenboom JP, Jakobi AJ, Jensen GJ, Jonker CTH, Kaag MJ, Koster AJ, Last MGF, de Agrela Pinto C, Plitzko JM, Raunser S, Tacke S, Wang Z, van der Wee EB, Wepf R, den Hoedt S. eLife (2022) [mehr]
Structural basis of actin filament assembly and aging

Structural basis of actin filament assembly and aging

Oosterheert W, Klink B. U, Belyy A, Pospich S, Raunser S. Nature (2022) [mehr]
Structural basis for specific inhibition of the deubiquitinase UCHL1

Structural basis for specific inhibition of the deubiquitinase UCHL1

Grethe C, Schmidt M, Kipka GM, O'Dea R, Gallant K, Janning P, Gersch M.
Nat Commun (2022)
  [mehr]
CRISPR screens in Drosophila cells identify Vsg as a Tc toxin receptor

CRISPR screens in Drosophila cells identify Vsg as a Tc toxin receptor

Xu Y, Viswanatha R, Sitsel O, Roderer D, Zhao H, Ashwood C, Voelcker C, Tian S, Raunser S, Perrimon N, Dong M. Nature (2022) [mehr]
Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin

Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin

d'Amico EA, Ud Din Ahmad M, Cmentowski V, Girbig M, Müller F, Wohlgemuth S, Brockmeyer A, Maffini S, Janning P, Vetter IR, Carter AP, Perrakis A. Musacchio A  (2020) Journal of Cell Biology [mehr]
Identification of a Novel Pseudo-Natural Product Type IV IDO1 Inhibitor Chemotype

Identification of a Novel Pseudo-Natural Product Type IV IDO1 Inhibitor Chemotype

Davies C, Dötsch L, Ciulla MG, Hennes E, Yoshida K, Gasper R, Scheel R, Sievers S, Strohmann C, Kumar K, Ziegler S, Waldmann H (2022). Angew Chem Int Ed Engl. [mehr]
Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector

Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector

Rai A, Singh AK, Bleimling N, Posern G, Vetter IR, Goody RS (2022). Nat Commun [mehr]
Mechanism of threonine ADP-ribosylation of F-actin by a Tc toxin

Mechanism of threonine ADP-ribosylation of F-actin by a Tc toxin

Belyy A, Lindemann F, Roderer D, Funk J, Bardiaux B, Protze J, Bieling P, Oschkinat H, Raunser S (2022). Nat Commun [mehr]
Structure of the human inner kinetochore CCAN complex and its significance for human centromere organization

Structure of the human inner kinetochore CCAN complex and its significance for human centromere organization

Pesenti ME, Raisch T, Conti D, Walstein K, Hoffmann I, Vogt D, Prumbaum D, Vetter IR, Raunser S, Musacchio A (2022). Mol Cell [mehr]
Structure of the RZZ complex and molecular basis of Spindly-driven corona assembly at human kinetochores

Structure of the RZZ complex and molecular basis of Spindly-driven corona assembly at human kinetochores

Raisch T, Ciossani G, d'Amico E, Cmentowski V, Carmignani S, Maffini S, Merino F, Wohlgemuth S, Vetter IR, Raunser S, Musacchio A (2022). EMBO J [mehr]
Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin

Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin

Wang Z, Grange M, Pospich S, Wagner T, Kho AL, Gautel M, Raunser S (2022). Science [mehr]
On the role of phase separation in the biogenesis of membraneless compartments

On the role of phase separation in the biogenesis of membraneless compartments

Musacchio A (2022) EMBO J. [mehr]
Structure of the Mon1-Ccz1 complex reveals molecular basis of membrane binding for Rab7 activation

Structure of the Mon1-Ccz1 complex reveals molecular basis of membrane binding for Rab7 activation

Klink BU, Herrmann E, Antoni C, Langemeyer L, Kiontke S, Gatsogiannis C, Ungermann C, Raunser S, Kümmel D (2022). Proc Natl Acad Sci U S A [mehr]
Synthesis of 20-Membered Macrocyclic Pseudo-Natural Products Yields Inducers of LC3 Lipidation

Synthesis of 20-Membered Macrocyclic Pseudo-Natural Products Yields Inducers of LC3 Lipidation

Niggemeyer G, Knyazeva A, Gasper R, Corkery D, Bodenbinder P, Holstein JJ, Sievers S, Wu YW, Waldmann H. (2022) Angew Chem Int Ed Engl. [mehr]

2021

A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks

A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks

Funk J, Merino F, Schaks M, Rottner K, Raunser S, Bieling P (2021) Nature Communications
Ultrarapid cryo-arrest of living cells on a microscope enables multiscale imaging of out-of-equilibrium molecular patterns

Ultrarapid cryo-arrest of living cells on a microscope enables multiscale imaging of out-of-equilibrium molecular patterns

Huebinger J, Grecco H, Masip ME, Christmann J, Fuhr GR, Bastiaens PIH (2021)
Targeted substrate loop insertion by VCP/p97 during PP1 complex disassembly

Targeted substrate loop insertion by VCP/p97 during PP1 complex disassembly

van den Boom J, Kueck AF, Kravic B, Müschenborn H, Giesing M, Pan D, Kaschani F, Kaiser M, Musacchio A, Meyer H (2021)
Small molecule modulation of the&nbsp;<em>Drosophila</em>&nbsp;Slo channel elucidated by cryo-EM

Small molecule modulation of the Drosophila Slo channel elucidated by cryo-EM

Raisch T, Brockmann A, Ebbinghaus-Kintscher U, Freigang J, Gutbrod O, Kubicek J, Maertens B, Hofnagel O, Raunser S (2021)
Molecular architecture of black widow spider neurotoxins

Molecular architecture of black widow spider neurotoxins

Chen M, Blum D, Engelhard L, Raunser S , Wagner R & Gatsogiannis C (2021)
High-resolution structures of the actomyosin-V complex in three nucleotide states provide insights into the force generation mechanism.

High-resolution structures of the actomyosin-V complex in three nucleotide states provide insights into the force generation mechanism.

Pospich S, Sweeney HL, Houdusse A, Raunser S (2021). eLife
&nbsp;Mechanism of actin-dependent activation of nucleotidyl cyclase toxins from bacterial human pathogens

 Mechanism of actin-dependent activation of nucleotidyl cyclase toxins from bacterial human pathogens

Belyy A, Merino F, Mechold U, Raunser S (2021), Nature Communications
Exploiting non-covalent interactions in selective carbohydrate synthesis

Exploiting non-covalent interactions in selective carbohydrate synthesis

Loh CCJ (2021). Nature Reviews Chemistry  
A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks

A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks

Funk J, Merino F, Schaks M, Rottner K, Raunser S, Bieling P (2021) Nature Communications
Dynamic Catalytic Highly Enantioselective 1,3-Dipolar Cycloadditions

Dynamic Catalytic Highly Enantioselective 1,3-Dipolar Cycloadditions

Yildirim O, Grigalunas M, Brieger L, Strohmann C, Antonchick AP, Waldmann H (2021). Dynamic Catalytic Highly Enantioselective 1,3-Dipolar Cycloadditions. Angew Chem Int Ed Engl.
Combination of pseudo-natural product design and formal natural product ring distortion yields stereochemically and biologically diverse pseudo-sesquiterpenoid alkaloids

Combination of pseudo-natural product design and formal natural product ring distortion yields stereochemically and biologically diverse pseudo-sesquiterpenoid alkaloids

Liu J, Flegel J, Otte F, Pahl A, Sievers S, Strohmann C, Waldmann H (2021). Angew Chem Int Ed Engl.
Assembly principles and stoichiometry of a complete human kinetochore module

Assembly principles and stoichiometry of a complete human kinetochore module

Walstein K, Petrovic A, Pan D, Hagemeier B, Vogt D, Vetter I & Musacchio A (2021) Science Advances
Growth factor–dependent ErbB vesicular dynamics couple receptor signaling to spatially and functionally distinct Erk pools

Growth factor–dependent ErbB vesicular dynamics couple receptor signaling to spatially and functionally distinct Erk pools

Brüggemann Y, Karajannis LS, Stanoev A, Stallaert W, Bastiaens PIH (2021) Science Signaling
Natural product fragment combination to performance-diverse pseudo-natural products

Natural product fragment combination to performance-diverse pseudo-natural products

Grigalunas M, Burhop A, Zinken S, Pahl A, Gally JM, Wild N, Mantel Y, Sievers S, Foley DJ, Scheel R, Strohmann C, Antonchick AP, Waldmann H (2021) Nat Commun.
The molecular basis for sarcomere organization in vertebrate skeletal muscle

The molecular basis for sarcomere organization in vertebrate skeletal muscle

Wang Z, Grange M, Wagner T, Khoo AL, Gautel M, Raunser S (2021) Cell 
A self-organized synthetic morphogenic liposome responds with shape changes to local light cues

A self-organized synthetic morphogenic liposome responds with shape changes to local light cues

Gavriljuk K, Scocozza B, Ghasemalizadeh F, Seidel H, Nandan AP, Campos-Medina M, Schmick M, Koseska A & Bastiaens PIH (2021) Nature Communications 
Cell-Based Identification of New IDO1 Modulator Chemotypes

Cell-Based Identification of New IDO1 Modulator Chemotypes

Hennes E, Lampe P, Dötsch L, Bruning N, Pulvermacher LM, Sievers S, Ziegler S, Waldmann H (2021) Angew Chem Int Ed Engl 
Cryo-EM resolves molecular recognition of an optojasp photoswitch bound to actin filaments in both switch states

Cryo-EM resolves molecular recognition of an optojasp photoswitch bound to actin filaments in both switch states

Pospich S, Küllmer F, Nasufovic V, Funk J, Belyy A, Bieling P, Arndt HD, Raunser S. (2021) Angew Chem Int Ed Engl 
Overlap of NatA and IAP substrates implicates N-terminal acetylation in protein stabilization

Overlap of NatA and IAP substrates implicates N-terminal acetylation in protein stabilization

Müller F, Friese A, Pathe C, Da Silva RC, Rodriguez KB, Musacchio A, Bange T (2021) Science Advances 
CDC20 assists its catalytic incorporation in the mitotic checkpoint complex

CDC20 assists its catalytic incorporation in the mitotic checkpoint complex

Piano V, Alex A, Stege P, Maffini S, Stoppiello GA, Huis In 't Veld PJ, Vetter IR, Musacchio A. (2021) Science 

2020

Optogenetic Tuning Reveals Rho Amplification-Dependent Dynamics of a Cell Contraction Signal Network

Optogenetic Tuning Reveals Rho Amplification-Dependent Dynamics of a Cell Contraction Signal Network

Kamps, D, Koch J, Juma VO, Campillo-Funollet E, Graessl M, Banerjee S, Mazel T, Chen X, Wu YW, Portet S, Madzvamuse A, Nalbant P, Dehmelt L (2020) Cell Reports

Source [mehr]
BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis

BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis

Singh P, Pesenti ME, Maffini S, Carmignani S, Hedtfeld M, Petrovic A, Srinivasamani A, Bange T, Musacchio A (2020) Mol Cell 
Quelle [mehr]
<p class="p1">Structural basis of TRPC4 regulation by calmodulin and pharmacological agents</p>

Structural basis of TRPC4 regulation by calmodulin and pharmacological agents

Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S (2020) eLife

Quelle [mehr]
Design, synthesis and biological evaluation of chemically and biologically diverse pyrroquinoline pseudo natural products

Design, synthesis and biological evaluation of chemically and biologically diverse pyrroquinoline pseudo natural products

Liu J, Cremosnik GS, Otte F, Pahl A, Sievers S, Strohmann C, Waldmann H  (2020) Angew Chem Int Ed Engl

Quelle   [mehr]
<p class="p1">TranSPHIRE: automated and feedback-optimized on-the-fly processing for cryo-EM</p>

TranSPHIRE: automated and feedback-optimized on-the-fly processing for cryo-EM

Stabrin M, Schoenfeld F, Wagner T, Pospich S, Gatsogiannis C, Raunser S (2020) Nat Commun

Quelle [mehr]
A protein tertiary structure mimetic modulator of the Hippo signalling pathway

A protein tertiary structure mimetic modulator of the Hippo signalling pathway

Adihou H, Gopalakrishnan R, Förster T, Guéret SM, Gasper R, Geschwindner S, Carrillo García C, Karatas H, Pobbati AV, Vazquez-Chantada M, Davey P, Wassvik CM, Pang JKS, Soh BS, Hong W, Chiarparin E, Schade D, Plowright AT, Valeur E, Lemurell M, Grossmann TN, Waldmann H. (2020) Nat Commun

Quelle [mehr]
Structure based design of bicyclic peptide inhibitors of RbAp48

Structure based design of bicyclic peptide inhibitors of RbAp48

Adihou H, 't Hart P, Hommen P, Noisier A, Krzyzanowski A, Schüler D, Porfetye AT, Akbarzadeh M, Vetter IR, Waldmann H (2020) Angew Chem Int Ed Engl

Quelle [mehr]
Processing Temporal Growth Factor Patterns by an Epidermal Growth Factor Receptor Network Dynamically Established in Space

Processing Temporal Growth Factor Patterns by an Epidermal Growth Factor Receptor Network Dynamically Established in Space

Koseska A, Bastiaens PIH (2020) Annu Rev Cell Biol

Quelle [mehr]
<p>A robust and tunable halogen bond organocatalyzed 2-deoxyglycosylation involving quantum tunneling</p>

A robust and tunable halogen bond organocatalyzed 2-deoxyglycosylation involving quantum tunneling

Xu C, Bhaskara Rao VU, Weigen J, Loh CCJ.  (2020) Nat Commun

Source [mehr]
Homeostatic Control of Meiotic Prophase Checkpoint Function by Pch2 and Hop1

Homeostatic Control of Meiotic Prophase Checkpoint Function by Pch2 and Hop1

Raina VB, Vader G (2020) Current Biology

doi: https://doi.org/10.1016/j.cub.2020.08.064. [mehr]
The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members

The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members

Rai A, Bleimling N, Vetter IR, Goody RS (2020) Nat Commun

doi: 10.1038/s41467-020-17792-3. [mehr]
<p>Glycan-dependent Cell Adhesion Mechanism of Tc Toxins</p>

Glycan-dependent Cell Adhesion Mechanism of Tc Toxins

Roderer D, Bröcker F, Sitsel O, Kaplonek P, Leidreiter F, Seeberger PH, Raunser S (2020) Nat Commun

doi: 10.1038/s41467-020-16536-7. [mehr]
Human Condensin I and II Drive Extensive ATP-Dependent Compaction of Nucleosome-Bound DNA

Human Condensin I and II Drive Extensive ATP-Dependent Compaction of Nucleosome-Bound DNA

Kong M, Cutts EE, Pan D, Beuron F, Kaliyappan T, Xue C, Morris EP, Musacchio A, Vannini A, Greene EC. (2020) Mol Cell

doi: 10.1016/j.molcel.2020.04.026. [mehr]
Cyclin B1 Scaffolds MAD1 at the Kinetochore Corona to Activate the Mitotic Checkpoint

Cyclin B1 Scaffolds MAD1 at the Kinetochore Corona to Activate the Mitotic Checkpoint

Allan LA, Camacho Reis M, Ciossani G, Huis In 't Veld PJ, Wohlgemuth S, Kops GJ, Musacchio A, Saurin AT. (2020) EMBO J.

doi: 10.15252/embj.2019103180. [mehr]
Evolved, Selective Erasers of Distinct Lysine Acylations

Evolved, Selective Erasers of Distinct Lysine Acylations

Spinck M, Neumann-Staubitz P, Ecke M, Gasper R, Neumann H (2020) Angew Chem Int Ed Engl.

doi: 10.1002/anie.202002899. [mehr]

2019

Clathrin’s adaptor interaction sites are repurposed to stabilize microtubules during mitosis

Clathrin’s adaptor interaction sites are repurposed to stabilize microtubules during mitosis

Rondelet A, Lin YC, Singh D, Porfetye AT, Thakur HC, Hecker A, Brinkert P, Schmidt N, Bendre S, Müller F, Mazul L, Widlund PO, Bange T, Hiller M, Vetter IR, Bird AW (2020). J Cell Biol

doi: 10.1083/jcb.201907083. [mehr]
SPHIRE-crYOLO is a fast and accurate fullyautomated particle picker for cryo-EM

SPHIRE-crYOLO is a fast and accurate fullyautomated particle picker for cryo-EM

Wagner T, Merino F, Stabrin S, Moriya T, Antoni C, Apelbau A, Hagel P, Sitsel O, Raisch T, Prumbaum D, Quentin D, Roderer D, Tacke S, Siebolds B, Schubert E, Shaikh TR, Lill P, Gatsogiannis C, Raunser S (2019). Communications Biology 

doi: doi.org/10.1038/s42003-019-0437. [mehr]
Development of a PDEδ targeting PROTAC that impairs lipid metabolism

Development of a PDEδ targeting PROTAC that impairs lipid metabolism

Winzker M, Friese A, Koch U, Janning P, Ziegler S. Waldmann H (2019). Angew Chem Int Ed Engl

doi: 10.1002/anie.201913712. [mehr]
<p>Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling</p>

Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling

Huis In 't Veld PJ, Volkov VA, Stender ID, Musacchio A, Dogterom M (2019). Elife

doi: 10.7554/eLife.49539. [mehr]
Towards the application of Tc toxins as a universal protein translocation system

Towards the application of Tc toxins as a universal protein translocation system

Roderer D, Schubert E, Sitsel O, Raunser S (2019). (2019). Nat Comms

doi: 10.1038/s41467-019-13253-8. [mehr]
<span>Image-based Morphological Profiling Identifies a Lysosomotropic, Iron-Sequestering Autophagy Inhibitor</span>

Image-based Morphological Profiling Identifies a Lysosomotropic, Iron-Sequestering Autophagy Inhibitor

Roderer D, Hofnagel O, Benz R, Raunser SLaraia L, Garivet G, Foley DJ, Kaiser N, Müller S, Zinken S, Pinkert T, Wilke J, Corkery D, Pahl A, Sievers S, Janning P, Arenz C, Wu Y, Rodriguez R, Waldmann H (2019). PNAS

doi: 10.1002/anie.201913712. [mehr]
<span>Structure of a Tc holotoxin pore provides insights into the translocation mechanism</span>

Structure of a Tc holotoxin pore provides insights into the translocation mechanism

Roderer D, Hofnagel O, Benz R, Raunser S (2019). PNAS

doi: 10.1073/pnas.1909821116. [mehr]
<span>Profilin and formin constitute a pacemaker system for robust actin filament growth</span>

Profilin and formin constitute a pacemaker system for robust actin filament growth

Funk J, Merino F, Venkova L, Heydenreich L, Kierfeld J, Vargas P, Raunser S, Piel M, Bieling P (2019). eLife

doi: 10.7554/eLife.50471 [mehr]
<span>Extraction of active RhoGTPases by RhoGDI regulates spatiotemporal patterning of RhoGTPases</span>

Extraction of active RhoGTPases by RhoGDI regulates spatiotemporal patterning of RhoGTPases

Gold AE, Visco I, Bieling P, Bement WM (2019). eLife

doi: 10.7554/eLife.50471 [mehr]
<p>Common architecture of Tc toxins from human and insect pathogenic bacteria</p>

Common architecture of Tc toxins from human and insect pathogenic bacteria

Leidreiter F, Roderer D, Meusch D, Gatsogiannis C, R. Benz R, Raunser S (2019). Science Advances

doi: 10.1126/sciadv.aax6497. [mehr]
<span>Cryo-EM structure of the ClpXP protein degradation machinery</span>

Cryo-EM structure of the ClpXP protein degradation machinery

Raisch T, Chang CT, Levdansky Y, Muthukumar S, Gatsogiannis C, Balogh D, Merino F, Sieber S, Raunser S (2019). Nat. Struct. Mol. Biol.

doi: 10.1038/s41594-019-0304-0. [mehr]
<span>Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing</span>

Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing

Pan D, Walstein K, Take A, Bier D, Kaiser N, Musacchio A (2019). Nature Communications

doi: 10.1038/s41467-019-12019-6. [mehr]
<span>Synthesis of Indomorphan Pseudo Natural Product Inhibitors of Glucose Transporters GLUT-1 and -3</span>

Synthesis of Indomorphan Pseudo Natural Product Inhibitors of Glucose Transporters GLUT-1 and -3

Ceballos J, Schwalfenberg M, Karageorgis G, Reckzeh ES, Sievers S, Ostermann C, Pahl A, Sellstedt M, Nowacki J, Carnero Corrales M, Wilke J, Laraia L, Tschapalda K, Metz M, Sehr DA, Brand S, Winklhofer K, Janning P, Ziegler S, Waldmann H (2019) Angew Chem Int Ed Engl

doi: 10.1002/anie.201909518. [mehr]
<span>Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß</span>

Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß

Kremer L, Hennes E, Brause A, Ursu A, Robke L, Matsubayashi HT, Nihongaki Y, Flegel J, Mejdrová I, Eickhoff J, Baumann M, Nencka R, Janning P, Kordes S, Schöler HR, Sterneckert J, Inoue T, Ziegler S, Waldmann H (2019). Angew Chem Int Ed Engl

doi: 10.1002/anie.201907632. [mehr]
<span>Design, Synthesis and Phenotypic Profiling of Pyrano-Furo-Pyridone Pseudo Natural Products</span>

Design, Synthesis and Phenotypic Profiling of Pyrano-Furo-Pyridone Pseudo Natural Products

Christoforow A, Wilke J, Binici A, Pahl A, Ostermann C, Sievers S, Waldmann H (2019). Angew Chem Int Ed Engl 

doi: 10.1002/anie.201907853. [mehr]
<span>Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation</span>

Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation

Raisch T, Chang CT, Levdansky Y, Muthukumar S, Raunser S, Valkov E (2019). Nature Communications

doi: 10.1038/s41467-019-11094-z. [mehr]
<span>The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis</span>

The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis

Laraia L, Friese A, Corkery Dp, Konstantinidis G, Erwin N, Hofer W, Karatas H, Klewer L, Brockmeyer A, Metz M, Schölermann
B, Dwivedi M, Li L, Rios-Munoz P, Köhn M, Winter R, Vetter IR, Ziegler S, Janning P, Wu YW and Waldmann H (2019).  Nat Chem Biol

 doi.org/10.1038/s41589-019-0307-5 [mehr]
Electroporated recombinant proteins as tools for in vivo functional complementation, imaging, and chemical biology

Electroporated recombinant proteins as tools for in vivo functional complementation, imaging, and chemical biology

Alex A, Piano V, Polley S, Stuiver M, Voss S, Ciossani G, Overlack K, Voss B, Wohlgemuth S, Petrovic A, Wu Y, Selenko P, Musacchio A, Maffini S (2019). Elife

 doi: 10.7554/eLife.48287 [mehr]
<span>Chemical genetics reveals a role of dCTP pyrophosphatase 1 in Wnt signaling</span>

Chemical genetics reveals a role of dCTP pyrophosphatase 1 in Wnt signaling

Friese A, Kapoor S, Schneidewind T, Vidadala SR, Sardana J, Brause A, Förster T, Bischoff M, Wagner J, Janning P, Ziegler S, Waldmann H (2019). Angwandte Chemie

doi: https://doi.org/10.1002/ejoc.201900586 [mehr]
The Pseudo Natural Product Myokinasib Is a Myosin Light Chain Kinase 1 Inhibitor with Unprecedented Chemotype

The Pseudo Natural Product Myokinasib Is a Myosin Light Chain Kinase 1 Inhibitor with Unprecedented Chemotype

Schneidewind T, Kapoor S, Garivet G, Karageorgis G, Narayan R, Vendrell-Navarro G, Antonchick AP, Ziegler S, Waldmann H (2019). Cell Chem Biol

 doi: 10.1016/j.chembiol.2018.11.014. [mehr]

2018

<span>Enantioselective Formal C(sp3 )-H Bond Activation in the Synthesis of Bioactive Spiropyrazolone Derivatives.</span>

Enantioselective Formal C(sp3 )-H Bond Activation in the Synthesis of Bioactive Spiropyrazolone Derivatives.

Li H, Gontla R, Flegel J, Merten C, Ziegler S, Antonchick AP, Waldmann H (2018). Angew Chem Int Ed Engl 

doi: 10.1002/anie.201811041.  [mehr]
Chromopynones are pseudo natural product glucose uptake inhibitors targeting glucose transporters GLUT-1 and -3

Chromopynones are pseudo natural product glucose uptake inhibitors targeting glucose transporters GLUT-1 and -3

Karageorgis G, Reckzeh ES, Ceballos J, Schwalfenberg M, Sievers S, Ostermann C, Pahl A, Ziegler S, Waldmann H (2018). Nat Chem. 

doi: 10.1038/s41557-018-0132-6.  [mehr]
A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation

A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation

Baumdick M, Gelléri M, Uttamapinant C, Beránek V, Chin JW, Bastiaens PIH (2018). Nat Commun 

doi: 10.1038/s41467-018-06299-7.  [mehr]
Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80

Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80

Pesenti ME, Prumbaum D, Auckland P, Smith CM, Faesen AC, Petrovic A, Erent M, Maffini S, Pentakota S, Weir JR, Lin YC, Raunser S, McAinsh AD, Musacchio A (2018). Mol Cell 

doi: 10.1016/j.molcel.2018.07.038.  [mehr]
<span>Mechanism of loading and translocation of type VI secretion system effector Tse6</span>

Mechanism of loading and translocation of type VI secretion system effector Tse6

Quentin D, Ahmad S, Shanthamoorthy P, Mougous JD, Whitney JC, Raunser S (2018). Nat Microbiol

 doi: 10.1038/s41564-018-0238-z.  [mehr]
<span>Tc toxin activation requires unfolding and refolding of a β-propeller</span>

Tc toxin activation requires unfolding and refolding of a β-propeller

Gatsogiannis C, Merino F, Roderer D, Balchin D, Schubert E, Kuhlee A, Hayer-Hartl M, Raunser S. (2018). Nature 

doi: 10.1038/s41586-018-0556-6.  [mehr]
<span>C-H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Hedgehog Pathway Inhibitors</span>

C-H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Hedgehog Pathway Inhibitors

Shan G, Flegel J, Li H, Merten C, Ziegler S, Antonchick AP, Waldmann H (2018). Angew Chem Ind Ed Engl


doi: 10.1002/anie.201809680. 
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Stanoev A, Mhamane A, Schuermann KC, Grecco HE, Stallaert W, Baumdick M, Brüggemann Y, Joshi MS, Roda-Navarro P, Fengler S, Stockert R, Roßmannek L, Luig J, Koseska A, Bastiaens PIH (2018). Interdependence between EGFR and Phosphatases Spatially Established by Vesicular Dynamics Generates a Growth Factor Sensing and Responding Network. Cell Syst
doi: 10.1016/j.cels.2018.06.006.

Brand S, Roy S, Schröder P, Rathmer B, Roos J, Kapoor S, Patil S, Pommerenke C, Maier T, Janning P, Eberth S, Steinhilber D, Schade D, Schneider G, Kumar K, Ziegler S, Waldmann H (2018). Combined proteomic and in silico target identification reveal a role for 5-Lipoxygenase in developmental signaling pathways. Cell Chem Bio
doi: https://doi.org/10.1016/j.chembiol.2018.05.016

Schubert E, Vetter IR, Prumbaum D, Penczek PA, Raunser S (2018). Membrane insertion of α-xenorhabdolysin in near-atomic detail. eLife
doi: 10.7554/eLife.38017.

Merino F, Pospich S, Funk J, Wagner T, Küllmer F, Arndt HD, Bieling P & Raunser S (2018). Structural transitions of F-actin upon ATP hydrolysis at near-atomic resolution revealed by cryo-EM. Nat Struct Mol Biol
doi: 10.1038/s41594-018-0074-0.

Vinayagam D, Mager T, Apelbaum A, Bothe A, Merino F, Hofnagel O, Gatsogiannis C, Raunser S (2018). Electron cryo-microscopy structure of the canonical TRPC4 ion channel. eLife
doi: 10.7554/eLife.36615.

Volkov VA, Huis In 't Veld PJ, Dogterom M, Musacchio A. (2018). Multivalency of NDC80 in the outer kinetochore is essential to track shortening microtubules and generate forces. eLife
doi: 10.7554/eLife.36764

Jia ZJ, Shan G, Daniliuc CG, Antonchick AP, Waldmann H (2018). Enantioselective Synthesis of the Spiro-Tropanyl Oxindole Scaffold Through Bimetallic Relay Catalysis. Angew Chem Int Ed Engl
doi: 10.1002/anie.201712882.


2017

Pentakota S, Zhou K, Smith C, Maffini S, Petrovic A, Morgan GP, Weir JR, Vetter IR, Musacchio A, Luger K (2017). Decoding the centromeric nucleosome through CENP-N. eLife
doi: 10.7554/eLife.33442.

Klink BU, Zent E, Juneja P, Kuhlee A, Raunser S, Wittinghofer A. (2017). A recombinant BBSome core complex and how it interacts with ciliary cargo. eLife
doi: 10.7554/eLife.27434.

Overlack K, Bange T, Weissmann F, Faesen AC, Maffini S, Primorac I, Müller F, Peters JM, Musacchio A (2017). BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint Signaling. Curr Biol
doi: 10.1016/j.cub.2017.08.033.

Pospich S, Kumpula EP, von der Ecken J, Vahokoski J, Kursula I, Raunser S. (2017). Near-atomic structure of jasplakinolide-stabilized malaria parasite F-actin reveals the structural basis