Ausgewählte Publikationen 2013 - 2022
2023
2022
2021
2020
2019
2018
Stanoev A, Mhamane A, Schuermann KC, Grecco HE, Stallaert W, Baumdick M, Brüggemann Y, Joshi MS, Roda-Navarro P, Fengler S, Stockert R, Roßmannek L, Luig J, Koseska A, Bastiaens PIH (2018). Interdependence between EGFR and Phosphatases Spatially Established by Vesicular Dynamics Generates a Growth Factor Sensing and Responding Network. Cell Syst
doi: 10.1016/j.cels.2018.06.006.
Brand S, Roy S, Schröder P, Rathmer B, Roos J, Kapoor S, Patil S, Pommerenke C, Maier T, Janning P, Eberth S, Steinhilber D, Schade D, Schneider G, Kumar K, Ziegler S, Waldmann H (2018). Combined proteomic and in silico target identification reveal a role for 5-Lipoxygenase in developmental signaling pathways. Cell Chem Bio
doi: https://doi.org/10.1016/j.chembiol.2018.05.016
Schubert E, Vetter IR, Prumbaum D, Penczek PA, Raunser S (2018). Membrane insertion of α-xenorhabdolysin in near-atomic detail. eLife
doi: 10.7554/eLife.38017.
Merino F, Pospich S, Funk J, Wagner T, Küllmer F, Arndt HD, Bieling P & Raunser S (2018). Structural transitions of F-actin upon ATP hydrolysis at near-atomic resolution revealed by cryo-EM. Nat Struct Mol Biol
doi: 10.1038/s41594-018-0074-0.
Vinayagam D, Mager T, Apelbaum A, Bothe A, Merino F, Hofnagel O, Gatsogiannis C, Raunser S (2018). Electron cryo-microscopy structure of the canonical TRPC4 ion channel. eLife
doi: 10.7554/eLife.36615.
Volkov VA, Huis In 't Veld PJ, Dogterom M, Musacchio A. (2018). Multivalency of NDC80 in the outer kinetochore is essential to track shortening microtubules and generate forces. eLife
doi: 10.7554/eLife.36764
Jia ZJ, Shan G, Daniliuc CG, Antonchick AP, Waldmann H (2018). Enantioselective Synthesis of the Spiro-Tropanyl Oxindole Scaffold Through Bimetallic Relay Catalysis. Angew Chem Int Ed Engl
doi: 10.1002/anie.201712882.
2017
Pentakota S, Zhou K, Smith C, Maffini S, Petrovic A, Morgan GP, Weir JR, Vetter IR, Musacchio A, Luger K (2017). Decoding the centromeric nucleosome through CENP-N. eLife
doi: 10.7554/eLife.33442.
Klink BU, Zent E, Juneja P, Kuhlee A, Raunser S, Wittinghofer A. (2017). A recombinant BBSome core complex and how it interacts with ciliary cargo. eLife
doi: 10.7554/eLife.27434.
Overlack K, Bange T, Weissmann F, Faesen AC, Maffini S, Primorac I, Müller F, Peters JM, Musacchio A (2017). BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint Signaling. Curr Biol
doi: 10.1016/j.cub.2017.08.033.
Pospich S, Kumpula EP, von der Ecken J, Vahokoski J, Kursula I, Raunser S. (2017). Near-atomic structure of jasplakinolide-stabilized malaria parasite F-actin reveals the structural basis of filament instability. Proc Natl Acad Sci U S A
doi: 10.1073/pnas.1707506114
Antonios D. Konitsiotis, Lisaweta Roßmannek, Angel Stanoev, Malte Schmick & Philippe I.H. Bastiaens (2017). Spatial cycles mediated by UNC119 solubilisation maintain Src family kinases plasma membrane localisation. Nat Commun 8:114
doi: 10.1038/s41467-017-00116-3.
Kremer L, Schultz-Fademrecht C, Baumann M, Habenberger P, Choidas A, Klebl B, Kordes S, Schöler HJ, Sterneckert J, Ziegler S, Schneider G., Waldmann H (2017). Discovery of a Novel Hedgehog Signaling Pathway Inhibitor by Cell-based Compound Discovery and Target Prediction. Angew Chem Int Ed Engl
doi: 10.1002/anie.201707394.
Robke L, Laraia L, Carnero Corrales MA, Konstantinidis G, Muroi M, Richters A, Winzker M, Engbring T, Tomassi S, Watanabe N, Osada H, Rauh D, Waldmann H, Wu Y, Engel J. (2017). Small-Molecule Inhibition of the UNC119-Cargo Interaction. Angew Chem Int Ed Engl
doi: 10.1002/anie.201703738.
Mosalaganti S, Keller J, Altenfeld A, Winzker M, Rombaut P, Saur M, Petrovic A, Wehenkel A, Wohlgemuth S, Müller F, Maffini S, Bange T, Herzog F, Waldmann H, Raunser S & Musacchio A (2017). Structure of the RZZ complex and molecular basis of its interaction with Spindly. J Cell Bio
doi: 10.1083/jcb.201611060.
Lee YC, Patil S, Golz C, Strohmann C, Ziegler S, Kumar K, Waldmann H (2017). A ligand-directed divergent catalytic approach to establish structural and functional scaffold diversity. Nat Commun 8:14043
doi: 10.1038/ncomms14043.
Jia ZJ, Merten C, Gontla R, Daniliuc CG, Antonchick AP, Waldmann H (2017). General Enantioselective C-H Activation with Efficiently Tunable Cyclopentadienyl Ligands. Angew Chem Int Ed Engl 56(9):2429-2434
doi: 10.1002/anie.201611981.
Martín-Gago P, Fansa EK, Klein CH, Murarka S, Janning P, Schürmann M, Metz M, Ismail S, Schultz-Fademrecht C, Baumann M, Bastiaens PI, Wittinghofer A, Waldmann H (2017). A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2. Angew Chem Int Ed Engl
doi: 10.1002/anie.201610957.
Faesen AC, Thanasoula M, Maffini S, Breit C, Müller F, van Gerwen S, Bange T, Musacchio A (2017). Basis of catalytic assembly of the mitotic checkpoint complex. Nature
doi: 10.1038/nature21384.
Laraia L, Ohsawa K, Konstantinidis G, Robke L, Wu YW, Kumar K, Waldmann H (2017). Discovery of Novel Cinchona-Alkaloid-Inspired Oxazatwistane Autophagy Inhibitors. Angew Chem Int Ed Engl 56(8):2145-2150.
doi: 10.1002/anie.201611670.
Pan D, Klare K, Petrovic A, Take A, Walstein K, Singh P, Rondelet A, Bird AW, Musacchio A (2017). CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading. eLife 6:e23352.
doi: 10.7554/eLife.23352.
2016
Huis In 't Veld PJ, Jeganathan S, Petrovic A, Singh P, John J, Krenn V, Weissmann F, Bange T, Musacchio A. (2016). Molecular basis of outer kinetochore assembly on CENP-T.eLife
doi: 10.7554/eLife.21007
Merino F, Raunser S (2016). Cryo-EM as a tool for structure-based drug development. Angew Chem Int Ed Engl
doi: 10.1002/anie.201608432
Petrovic A, Keller J, Liu Y, Overlack K, John J, Dimitrova YN, Jenni S, van Gerwen S, Stege P, Wohlgemuth S, Rombaut P, Herzog F, Harrison SC, Vetter IR, and Musacchio A (2016). Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores. Cell 167(4):1028-1040.
doi: http://dx.doi.org/10.1016/j.cell.2016.10.005
Weir JR, Faesen AC, Klare K, Petrovic A, Basilico F, Fischböck J, Pentakota S, Keller J, Pesenti ME, Pan D, Vogt D, Wohlgemuth S, Herzog F, Musacchio A (2016). Insights from biochemical reconstitution into the architecture of human kinetochores. Nature 537(7619):249-253.
doi: 10.1038/nature19333.
von der Ecken J, Heissler SM, Pathan-Chhatbar S, Manstein DJ & Raunser S (2016).Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution. Nature 534(7609):724-28.
doi: 10.1038/nature18295
freely available!
Masip ME, Huebinger J, Christmann J, Sabet O, Wehner F, Konitsiotis A, Fuhr GR, Bastiaens PI (2016). Reversible cryo-arrest for imaging molecules in living cells at high spatial resolution. Nat Methods. 13(8):665-72.
doi: 10.1038/nmeth.3921
Spiegel J, Cromm PM, Itzen A, Goody RS, Grossmann TN & Waldmann H (2014). Direct Targeting of Rab-GTPase-Effector Interactions. Angew Chem Int Ed Engl 53(9), 2498-2503.
doi: 10.1002/anie.201308568
Liu Y, Petrovic A, Rombaut P, Mosalaganti S, Keller J, Raunser S, Herzog F & Musacchio A (2016). Insights from the reconstitution of the divergent outer kinetochore of Drosophila melanogaster. Open Biol 6.
doi: 10.1098/rsob.150236.
Gatsogiannis C, Merino F, Serdiuk T, Prumbaum D, Roderer D, Leidreiter F, Meusch D, Müller DJ, and Raunser S (2016). Membrane insertion of a Tc toxin in atomic detail. Nature Structural and Molecular Biology 23(10):884-890.
doi: 10.1038/nsmb.3281
freely available!
Papke B, Murarka S, Vogel HA, Martín-Gago P, Kovacevic M, Truxius DC, Fansa EK, Ismail S, Zimmermann G, Heinelt K, Schultz-Fademrecht C, Al Saabi A, Baumann M, Nussbaumer P, Wittinghofer A, Waldmann H, Bastiaens PI (2016). Identification of pyrazolopyridazinones as PDEδ inhibitors. Nat Commun 7:11360.
doi: 10.1038/ncomms11360.
Ursu A, Illich DJ, Takemoto Y, Porfetye AT, Zhang M, Brockmeyer A, Janning P, Watanabe N, Osada H, Vetter IR, Ziegler S, Schöler HR & Waldmann H (2016). Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1. Cell Chem Biol 23(4), 494-507.
doi: 10.1016/j.chembiol.2016.02.015
Subramanian VV, MacQueen AJ, Vader G, Shinohara M, Sanchez A, Borde V, Shinohara A, Hochwagen A. (2016). Chromosome Synapsis Alleviates Mek1-Dependent Suppression of Meiotic DNA Repair. PLoS Biology 12;14(2):e1002369
doi: 10.1371/journal.pbio.1002369.
Christmann J, Azer L, Dörr D, Fuhr GR, Bastiaens PIH, Wehner F (2016). Adaptive Responses of Cell Hydration to a Low Temperature Arrest. J Physiol 594.6, 1663-1676
doi: 10.1113/JP271245
2015
Efremov R, Hofnagel O, Raunser S (2015). Architecture and Conformational Switch Mechanism of the Ryanodine Receptor. Nature 517(7532):39-43.
doi: 10.1038/nature13916
freely available!
von der Ecken J, Müller M, Lehman W, Manstein DJ, Penczek PA, Raunser S (2015). Structure of the F-actin-tropomyosin complex. Nature 519(7541):114-7.
doi: 10.1038/nature14033
freely available!
Whitney JC, Quentin D, Sawai S, LeRoux M, Harding BN, Ledvina HE, Tran BQ, Robinson H, Goo YA, Goodlett DR, Raunser S, Mougous JD (2015). An Interbacterial NAD(P)(+) Glycohydrolase Toxin Requires Elongation Factor Tu for Delivery to Target Cells. Cell 163(3):607-19.
doi: 10.1016/j.cell.2015.09.027
Baumdick M, Brüggemann Y, Schmick M, Xouri G, Sabet O, Davis L, Chin JW, Bastiaens PI (2015). EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling. eLife 4: e12223.
doi: 10.7554/eLife.12223
Vidadala SR, Golz C, Strohmann C, Daniliuc CG & Waldmann H (2015). Highly enantioselective intramolecular 1,3-dipolar cycloaddition: a route to piperidino-pyrrolizidines. Angew Chem Int Ed Engl 54(2), 651-655
doi: doi: 10.1002/anie.201409942
Schröder P, Förster T, Kleine S, Becker C, Richters A, Ziegler S, Rauh D, Kumar K & Waldmann H (2015). Neuritogenic militarinone-inspired 4-hydroxypyridones target the stress pathway kinase MAP4K4. Angew Chem Int Ed Engl 54(42).
doi: 10.1002/anie.201501515
Akbulut Y, Gaunt HJ, Muraki K, Ludlow MJ, Amer MS, Bruns A, Vasudev NS, Radtke L, Willot M, Hahn S, Seitz T, Ziegler S, Christmann M, Beech DJ & Waldmann H (2015). (-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels. Angew Chem Int Ed Engl 54(12), 3787-3791.
doi: 10.1002/anie.201411511
Vincenten N, Kuhl LM, Lam I, Oke A, Kerr ARW, Hochwagen A, Fung J, Keeney S, Vader G*, Marston AL* (2015). The kinetochore prevents centromere-proximal crossover recombination during meiosis eLife 14;4.
doi: 10.7554/eLife.10850
Švenda J, Sheremet M, Kremer L, Maier L, Bauer JO, Strohmann C, Ziegler S, Kumar K & Waldmann H (2015). Biology-oriented synthesis of a withanolide-inspired compound collection reveals novel modulators of hedgehog signaling. Angew Chem Int Ed Engl 54(19) 5596-5602
doi: doi: 10.1002/anie.201409942
Sabet O, Stockert R, Xouri G, Brüggemann Y, Stanoev A, Bastiaens PI. (2015). Ubiquitination switches EphA2 vesicular traffic from a continuous safeguard to a finite signaling mode. Nat Commun 6:8047.
doi: 10.1038/ncomms9047
Klare K, Weir JR, Basilico F, Zimniak T, Massimiliano L, Ludwigs N, Herzog F & Musacchio A (2015). CENP-C is a blueprint for constitutive centromere-associated network assembly within human kinetochores. J Cell Biol 210:11-22.
doi: 10.1083/jcb.201412028
Overlack K, Primorac I, Vleugel M, Krenn V, Maffini S, Hoffmann I, Kops GJ & Musacchio A (2015). A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint. eLife 4:e05269.
doi: 10.7554/eLife.05269
Gatsogiannis C, Hofnagel O, Markl J, Raunser S (2015). Structure of Mega-Hemocyanin reveals protein origami in snails. Structure 23(1):93-103.
doi: 10.1016/j.str.2014.10.013
Ibach J, Radon Y, Gelleri M, Sonntag MH, Brunsveld L, Bastiaens PI, Verveer PJ (2015). Single Particle Tracking Reveals that EGFR Signaling Activity Is Amplified in Clathrin-Coated Pits. PLoS One 10(11):e0143162.
doi: 10.1371/journal.pone.0143162
Arndt HD, Rizzo S, Nöcker C, Wakchaure VN, Milroy LG, Bieker V, Calderon A, Tran TT, Brand S, Dehmelt L, Waldmann H (2015). Divergent solid-phase synthesis of natural product-inspired bipartite cyclodepsipeptides: total synthesis of seragamide A. Chemistry 21:5311 (2015)
doi: 10.1002/chem.201500368
2014
Schmick M, Vartak N, Papke B, Kovacevic M, Truxius DC, Rossmannek L & Bastiaens PIH (2014). KRas Localizes to the Plasma Membrane by Spatial Cycles of Solubilization, Trapping and Vesicular Transport. Cell 157(2):459-471.
doi: 10.1016/j.cell.2014.02.051
Meusch D, Gatsogiannis C, Efremov R, Lang A, Hofnagel O, Vetter I, Aktories K, Raunser S (2014). Mechanism of Tc toxin action revealed in molecular detail. Nature 508(7494):61-5.
doi: 10.1038/nature13015
freely available!
Basilico F, Maffini S, Weir JR, Prumbaum D, Rojas AM, Zimniak T, De Antoni A, Jeganathan S, Voss B, van Gerwen S, Krenn V, Massimiliano L, Valencia A, Vetter IR, Herzog F, Raunser S, Pasqualato S & Musacchio A (2014). The pseudo GTPase CENP-M drives human kinetochore assembly. eLife 8:e02978.
doi: doi: 10.7554/eLife.02978
Eschenbrenner-Lux V, Küchler P, Ziegler S, Kumar K & Waldmann H (2014). An enantioselective inverse-electron-demand imino Diels-Alder reaction. Angew Chem Int Ed Engl 53(8), 2134-2137, doi: 10.1002/anie.201309022.
doi: 10.1002/anie.201309022
Spiegel J, Cromm PM, Itzen A, Goody RS, Grossmann TN & Waldmann H (2014). Direct Targeting of Rab-GTPase-Effector Interactions. Angew Chem Int Ed Engl 53(9), 2498-2503.
doi: 10.1002/anie.201308568
Hoffmann J-H, Fermin Y, Stricker RLO, Ickstadt K, and Zamir E.* (2014). Symmetric exchange of multi-protein building blocks between stationary focal adhesions and the cytosol. eLife 3:e02257
doi: 10.7554/eLife.02257
Petrovic A, Mosalaganti S, Keller J, Mattiuzzo M, Overlack K, Krenn V, De Antoni A, Wohlgemuth S, Cecatiello V, Pasqualato S, Raunser S & Musacchio A (2014). Modular Assembly of RWD Domains on the Mis12 Complex Underlies Outer Kinetochore Organization. Mol Cell 53:591-605.
doi: 10.1016/j.molcel.2014.01.019
Klare K, Weir JR, Basilico F, Zimniak T, Massimiliano L, Ludwigs N, Herzog F & Musacchio A (2015). CENP-C is a blueprint for constitutive centromere-associated network assembly within human kinetochores. J Cell Biol 210:11-22.
doi: 10.1083/jcb.201412028
Krenn V, Overlack K, Primorac I, van Gerwen S & Musacchio A (2014). KI motifs of human Knl1 enhance assembly of comprehensive spindle checkpoint complexes around MELT repeats. Curr Biol 24:29-39.
doi: 10.1016/j.cub.2013.11.046
Vartak N, Papke B, Grecco HE, Rossmannek L, Waldmann H, Hedberg C, Bastiaens PIH (2014). Autocatalytic APT depalmitoylation maintains spatial organization of palmitoylated membrane proteins. Biophys . 106(1):93-105.
Gatsogiannis C, Hofnagel O, Markl J, Raunser S (2015). Structure of Mega-Hemocyanin reveals protein origami in snails. Structure 23(1):93-103.
doi: 10.1016/j.str.2014.10.013
Mazel T, Biesemann A, Krejczy M, Nowald J, Müller O and Dehmelt L (2014). Direct observation of microtubule pushing by cortical dynein in living cells. Mol Biol Cell 25:95
doi: 10.1091/mbc.E13-07-0376
Liu P, Calderon A, Konstantinidis G, Hou J, Voss S, Chen X, Li F, Banerjee S, Hoffmann J-E, Theiss C, Dehmelt L, Wu Y-W (2014). A Bioorthogonal Small-molecule Switch System for Controlling Protein Function in Cells. Angew Chem Int Ed 53:10049
doi: 10.1002/anie.201403463
Schulze N, Gräßl M, Soares AB, Geyer M, Dehmelt L, Nalbant P (2014). FHOD1 regulates stress fiber organization by controlling transversal arc and dorsal fiber dynamics. J Cell Sci 127:1379
doi: 10.1242/jcs.134627
2013
Zimmermann G, Papke B, Ismail S, Vartak N, Chandra A, Hoffmann M, Hahn SA, Triola G, Wittinghofer A, Bastiaens PI, Waldmann H (2013). Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature 30;497(7451):638-42.
doi: 10.1038/nature12205
Gatsogiannis C, Lang A, Meusch D, Pfaumann V, Hofnagel O, Benz R, Aktories K, Raunser S (2013). A syringe-like injection mechanism in Photorhabdus luminescens toxins. Nature. 495(7442):520-23
doi: 10.1038/nature11987
freely available!
Primorac I, Weir JR, Chiroli E, Gross F, Hoffmann I, van Gerwen S, Ciliberto A & Musacchio A (2013). Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signalling. Elife 2:e01030.
doi: 10.7554/eLife.01030.
Gandor S, Reisewitz S, Venkatachalapathy M, Arrabito G, Reibner M, Schröder H, Ruf K, Niemeyer CM, Bastiaens PI, Dehlmelt L (2013). A protein-interaction array inside a living cell. Angew Chem Int Ed Engl 52;18. P.4790-4794.
doi:10.1002/anie.201209127