Evolved, Selective Erasers of Distinct Lysine Acylations
Spinck M, Neumann-Staubitz P, Ecke M, Gasper R, Neumann H (2020) Angew Chem Int Ed Engl.
doi: 10.1002/anie.202002899.
Cellular proteins exhibit complex lysine acylation patterns, that are reversed by a small set of substrate promiscuous lysine deacetylases (KDACs). The Neumann group device a strategy to create KDAC variants with increased selectivity towards particular types of lysine acylations using a novel selection system and use them to alter the acylation pattern of cells.
![original](/3872102/original-1584729885.jpg?t=eyJ3aWR0aCI6MjQ2LCJvYmpfaWQiOjM4NzIxMDJ9--2aee2333cf8b5fefe3b7d3eda53ae243c2a74d2b)