Evolved, Selective Erasers of Distinct Lysine Acylations

Spinck M, Neumann-Staubitz P, Ecke M, Gasper R, Neumann H (2020) Angew Chem Int Ed Engl.

doi: 10.1002/anie.202002899.

Cellular proteins exhibit complex lysine acylation patterns, that are reversed by a small set of substrate promiscuous lysine deacetylases (KDACs). The Neumann group device a strategy to create KDAC variants with increased selectivity towards particular types of lysine acylations using a novel selection system and use them to alter the acylation pattern of cells.

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