We are interested in mechanisms, how the dynamic shape of cells emerges from interactions between cytoskeletal structures and their regulators.
We use cryo-electron microscopy to study the
structure and function of membrane proteins
and macromolecular complexes.
How do cells process extracellular information and thereby determine their identity?
We study the molecular mecahnisms that regulate changes in cell morphology.
How do cells fuse together?
Roles and mechanisms of Ras-family GTPase, in particular Rab GTPase, in the regullation of intracellular vesicukar transport
How do cellular functions work together to faithfully segregate the genome?
We want to understand the dynamic interaction between pore forming proteins and lipid membranes.
Mass spectrometry analysis of organic compounds, proteins and proteom.
Finding the needle in the haystack: Exploring the mechanism of action of bioactive small molecules.
We investigate the molecular basis of cell division in eukaryotes.
We develop novel synthesis to produce natural product-inspired compound collections and use them for the study of biological phenomena.
How do cells turn signal into fate?
We determine the 3D structure of proteins and protein complexes via X-ray crystallography.
We want to understand the complex molecular organization, structure and function of Kinetochores
Our lab is interested in exploring biologically-relevant chemical space through the chemical evolution of natural product structure guided by the concept of pseudo-natural products.
Our Research Groups
The Institute consists of four departments. Each of them is headed by a director and is scientifically autonomous. In each of the four departments, thematically related research groups are integrated. They have their own scientific priorities and pursue independent research projects.
In our projects, we not only think in departments or disciplines. We focus on communication and cooperation. We draw inspiration from each other’s different perspectives, develop joint projects and thus benefit from the expertise of the other subject areas.