Portrait Prof. Dr. Bastiaens

Philippe Bastiaens

Director, Systemic Cell Biology

News and Press Releases

Cool Microscopy

Cool Microscopy

December 13, 2021
Ultrarapid cooling enables the observation of molecular patterns of life
December 13, 2021

Research Interests

> Department Systemic Cell Biology

Cognition emerges from the pattern forming activity of biochemical networks that execute cell signaling, and we are generally interested in how the dynamics of biochemical networks generate the spatial organization of signaling systems. Our attention is currently focused on the interdependence of membrane dynamics and early growth factor signal processing in cells. In this context, we investigate how the interaction of receptor tyrosine kinases (RTKs), small GTPases and Src family kinases with membrane systems affects the dynamics of signaling networks and thereby change the cell’s perception of the environment. Based on these studies, we opened new avenues for pharmacological interference with oncogenic signaling in cancer cells. We have also started a new synthetic biology research line in which we reconstitute from biochemical building blocks a trinity of signaling, cytoskeletal dynamics, and membrane shape that interact within a closed-loop causality to give rise to a self-organized morphogenic system.

Selected Publications

PubMed Liste>

Huebinger J, Grecco H, Masip ME, Christmann J, Fuhr GR, Bastiaens PIH (2021).Ultrarapid cryo-arrest of living cells on a microscope enables multiscale imaging of out-of-equilibrium molecular patterns.  Science Advances

Gavriljuk K, Scocozza B, Ghasemalizadeh F, Seidel H, Nandan AP, Campos-Medina M, Schmick M, Koseska A & Bastiaens PIH (2021). A self-organized synthetic morphogenic liposome responds with shape changes to local light cues.  Nature Communications

Koseska A, Bastiaens PIH (2020). Processing Temporal Growth Factor Patterns by an Epidermal Growth Factor Receptor Network Dynamically Established in Space Annu Rev Cell Dev Biol
doi: 10.1146/annurev-cellbio-013020-103810

Baumdick M, Gelléri M, Uttamapinant C, Beránek V, Chin JW, Bastiaens PIH (2018). A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation. Nat Commun
doi: 10.1038/s41467-018-06299-7.

Stanoev A, Mhamane A, Schuermann KC, Grecco HE, Stallaert W, Baumdick M, Brüggemann Y, Joshi MS, Roda-Navarro P, Fengler S, Stockert R, Roßmannek L, Luig J, Koseska A, Bastiaens PIH (2018). Interdependence between EGFR and Phosphatases Spatially Established by Vesicular Dynamics Generates a Growth Factor Sensing and Responding Network. Cell Syst
doi: 10.1016/j.cels.2018.06.006.

Stallaert W, Brüggemann Y, Sabet O, Baak L, Gattiglio M, Bastiaens PIH (2018). Contact inhibitory Eph signaling suppresses EGF-promoted cell migration by decoupling EGFR activity from vesicular recycling. Sci Sig
doi: 10.1126/scisignal.aat0114.

Tsutsumi R, Harizanova J, Stockert R, Schröder K, Bastiaens PIH, Neel BG. (2017). Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2. Nat Commun 8(1):466
doi: 10.1038/s41467-017-00503-w.

Antonios D. Konitsiotis, Lisaweta Roßmannek, Angel Stanoev, Malte Schmick & Philippe I.H. Bastiaens (2017). Spatial cycles mediated by UNC119 solubilisation maintain Src family kinases plasma membrane localisation. Nat Commun 8:114
doi: 10.1038/s41467-017-00116-3.

Papke B, Murarka S, Vogel HA, Martín-Gago P, Kovacevic M, Truxius DC, Fansa EK, Ismail S, Zimmermann G, Heinelt K, Schultz-Fademrecht C, Al Saabi A, Baumann M, Nussbaumer P, Wittinghofer A, Waldmann H, Bastiaens PI (2016). Identification of pyrazolopyridazinones as PDEδ inhibitors. Nat Commun 7:11360. doi: 10.1038/ncomms11360.
doi: 10.1038/ncomms11360.

Masip ME, Huebinger J, Christmann J, Sabet O, Wehner F, Konitsiotis A, Fuhr GR, Bastiaens PI (2016). Reversible cryo-arrest for imaging molecules in living cells at high spatial resolution. Nat Methods. 13(8):665-72.
doi: 10.1038/nmeth.3921

Sabet O, Stockert R, Xouri G, Brüggemann Y, Stanoev A, Bastiaens PI (2015). Ubiquitination switches EphA2 vesicular traffic from a continuous safeguard to a finite signaling mode. Nat Commun 6:8047.
doi: 10.1038/ncomms9047.

Ibach J, Radon Y, Gelleri M, Sonntag MH, Brunsveld L, Bastiaens PI, Verveer PJ (2015). Single Particle Tracking Reveals that EGFR Signaling Activity Is Amplified in Clathrin-Coated Pits. PLoS One 10(11):e0143162.
doi: 10.1371/journal.pone.0143162.

Baumdick M, Brüggemann Y, Schmick M, Xouri G, Sabet O, Davis L, Chin JW, Bastiaens PI (2015). EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling. ELife 4: e12223.
doi: 10.7554/eLife.12223.

Roda-Navarro P, Bastiaens PI (2014). Dynamic recruitment of protein tyrosine phosphatase PTPD1 to EGF stimulation sites potentiates EGFR activation. PLoS One 9(7):e103203.
doi: 10.1371/journal.pone.0103203.

Schmick M, Vartak N, Papke B, Kovacevic M, Truxius DC, Rossmannek L, Bastiaens PI (2014). KRas localizes to the plasma membrane by spatial cycles of solubilization, trapping and vesicular transport. Cell 157(2):459-71.
doi: 10.1016/j.cell.2014.02.051.

Vartak N, Papke B, Grecco HE, Rossmannek L, Waldmann H, Hedberg C, Bastiaens PIH (2014). Autocatalytic APT depalmitoylation maintains spatial organization of palmitoylated membrane proteins. Biophys J 106(1):93-105
doi: 10.1016/j.bpj.2013.11.024.

Zimmermann G, Papke B, Ismail S, Vartak N, Chandra A, Hoffmann M, Hahn SA, Triola G, Wittinghofer A, Bastiaens PI, Waldmann H (2013). Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature 30;497(7451):638-42
doi: 10.1038/nature12205.

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