Signals in Space and Time
We study how the spatial organization and the collective dynamics of signaling molecules determine the behavior of cells.
Making the Invisible Visible
Cryo-electron microscopy enables us to determine the 3D structure of medically relevant protein complexes.
Understanding Fundamental Processes
We investigate which molecular mechanisms regulate cell division, because errors can lead to serious malformations or cancer.
Nature as a Model
Natural substances were optimized in their effect in a long evolutionary process. That is why they are an inspiration for drug discovery.
Innovative cell biology, screening assays and chemical probes
We discover novel therapeutic targets with a focus on RNA interactions and the ubiquitin system
We are bridging scales
Researchers who seek to elucidate the complex processes of life rely on a broad spectrum of scientific methods, perspectives and ideas. We – an international team of chemists, cell biologists, biochemists and physicists – cooperate in many of our projects across research fields and thus link the expertise of our various disciplines. The aim of our research is to gain a holistic picture of how key proteins mediate vital processes and how networks of proteins regulate the behavior of living cells.
We analyze which molecular mechanisms strictly control and regulate the process of cell division to prevent faulty chromosome distribution and the resulting damage.
We investigate which signaling pathways cells use to respond to external disturbances and which errors in the collective behavior of the molecules lead to the emergence of diseases such as cancer.
We specifically focus on the structural and functional analysis of protein complexes involved in toxin-mediated membrane permeation, the molecular details of muscle contraction and the dynamics of the eukaryotic cytoskeleton.
We develop active substances based on models from nature to target and intervene into biological processes and to investigate the interaction of molecules. We also seek to discover substances that will correct or halt the pathogenic, derailed processes.