Dr. Slava Ziegler
Project Group Leader, Chemical Biology
Small molecules are powerful tools to investigate and manipulate complex biological systems and the identification and synthesis of bioactive small molecules that specifically target cellular processes are at the heart of chemical biology research. The exposure of small molecules to living systems bears the potential to uncover and perturb (novel) functions of proteins. The major challenge in this process is to unravel the molecular targets of given small molecules, i.e. the direct binding partners, the biomolecules whose function is perturbed by the compound. We develop target-based and phenotypic assays to identify biologically active compounds and employ chemical proteomics and biochemical, biophysical and genetic approaches to decipher their mechanism of action.