Slava Ziegler

Slava Ziegler

Project Group Leader, Chemical Biology


Research Interests

Our lab develops and employs phenotypic assays to identify bioactive small molecules. We therefore develop and employ phenotypic assays to identify bioactive small molecules. Our aim is to identify modulators of various processes that contribute to tumorigenesis, e.g. developmental pathways, deregulated cellular energetics, oxidative stress and immune cell-assisted cancer cell elimination.

News/Jobs

We regularly offer biological projects for Bachelor and Master theses as well as for postdoctoral studies. Interested and motivated students and PhDs are encouraged to apply.

Selected Publications

PubMed List>

Schneidewind T, Brause A, Pahl A, Burhop A, Mejuch T, Sievers S, Waldmann H , Ziegler S (2020). Morphological Profiling Enables the Identification of Common Mode of Action for Small Molecules With Different Targets. ChemBioChem   
doi: 10.1002/cbic.202000381 

Ceballos J, Schwalfenberg M, Karageorgis G, Reckzeh ES, Sievers S, Ostermann C, Pahl A, Sellstedt M, Nowacki J, Carnero Corrales M, Wilke J, Laraia L, Tschapalda K, Metz M, Sehr DA, Brand S, Winklhofer K, Janning P, Ziegler S, Waldmann H (2019). Synthesis of Indomorphan Pseudo Natural Product Inhibitors of Glucose Transporters GLUT-1 and -3. Angew Chem Int Ed Engl 
doi: 10.1002/anie.201909518.

Reckzeh ES, Karageorgis G, Schwalfenberg M, Ceballos J, Nowacki J, Stroet MCM, Binici A, Knauer L, Brand S, Choidas A, Strohmann C, ZieglerS, Waldmann H (2019). Inhibition of Glucose Transporters and Glutaminase Synergistically Impairs Tumor Cell Growth Cell Chemical Biology 
https://doi.org/10.1016/j.chembiol.2019.06.005

Kremer L, Hennes E, Brause A, Ursu A, Robke L, Matsubayashi HT, Nihongaki Y, Flegel J, Mejdrová I, Eickhoff J, Baumann M, Nencka R, Janning P, Kordes S, Schöler HR, Sterneckert J, Inoue T, Ziegler S, Waldmann H (2019). Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß. Angew Chem Int Ed Engl  
doi: 10.1002/anie.201907632.

Brand S, Roy S, Schröder P, Rathmer B, Roos J, Kapoor S, Patil S, Pommerenke C, Maier T, Janning P, Eberth S, Steinhilber D, Schade D, Schneider G, Kumar K, Ziegler S, Waldmann H (2018). Combined proteomic and in silico target identification reveal a role for 5-Lipoxygenase in developmental signaling pathways. Cell Chem Bio 
doi: https://doi.org/10.1016/j.chembiol.2018.05.016

Akbulut Y, Gaunt HJ, Muraki K, Ludlow MJ, Amer MS, Bruns A, Vasudev NS, Radtke L, Willot M, Hahn S, Seitz T, Ziegler S, Christmann M, Beech DJ & Waldmann H (2015). (-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels. Angew Chem Int Ed Engl 54(12):3787-3791. 
doi: 10.1002/anie.201411511. 

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