Willkommen am MPI für molekulare Physiologie

Jeden Tag sorgen Billionen von Zellen im Körper dafür, dass wir sehen, denken, sprechen und uns bewegen können. Woher weiß jede Zelle, was ihre Aufgabe ist? Wie kann aus einer unvorstellbaren Vielzahl von nanometergroßen Molekülen ein Organismus entstehen, obwohl es keinen Bauplan gibt? Was ist überhaupt „Leben“? Seit Jahrhunderten versuchen Philosophen und Naturforscher, dieses Rätsel zu ergründen. Doch viele Fragen sind bis heute ungeklärt.
Wir wollen wissen, wie die Bausteine der Zellen sich selbst organisieren und dafür sorgen, dass bestimmte chemische Reaktionen zur richtigen Zeit am richtigen Ort geschehen – oder aber Fehler dazu führen, dass Krankheiten wie Krebs entstehen. Dazu erforschen wir die maßgeblichen Prozesse auf mehreren Ebenen. Von einzelnen Molekülen über größere Proteinkomplexe bis hin zu ganzen Zellen.

Aktuelle Nachrichten

Wir gratulieren den besten Biologie-AbiturientInnen NRWs, die im Rahmen eines Festakts vom VBIO mit dem Karl-von-Frisch Preis am MPI in Dortmund ausgezeichnet wurden.
Wohin mit Kopf und Schwanz?
beta-Catenin als neuer Schlüsselspieler bei der Ausbildung der Hauptkörperachse während der Embryogenese von Säugetieren entdeckt
Boehringer Ingelheim Stiftung unterstützt Forschung von Peng Wu
Peng Wu erhält ca. 1 Million Euro von der Boehringer Ingelheim Stiftung für die Entwicklung neuartiger RNA-gerichteter Medikamente

Forschung am Institut

Stereoselective Entry into α,α’-C-Oxepane Scaffolds through a Chalcogen Bonding Catalyzed Strain-Release C-Septanosylation Strategy
Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP
Tissue-intrinsic beta-catenin signals antagonize Nodal-driven anterior visceral endoderm differentiation
Transient Structural Properties of the Rho GDP-Dissociation Inhibitor
Tafbromin selectively targets the TAF1 bromodomain
A validation strategy to assess the role of phase separation as a determinant of macromolecular localization
Molecular mechanism of actin filament elongation by formins
Asymmetric Pd/Organoboron-Catalyzed Site-Selective Carbohydrate Functionalization with Alkoxyallenes Involving Noncovalent Stereocontrol
Harnessing Multistep Chalcogen Bonding Activation in the α-Stereoselective Synthesis of Iminoglycosides
Structure of the human KMN complex and implications for regulation of its assembly
A divergent intermediate strategy yields biologically diverse pseudo-natural products
N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1
Yersinia entomophaga Tc toxin is released by T10SS-dependent lysis of specialized cell subpopulations
Key Publications 2023
Exploiting π and Chalcogen Interactions for the β-Selective Glycosylation of Indoles through Glycal Conformational Distortion
Structure and activation mechanism of the Makes caterpillars floppy 1 toxin
Cooperative Bifurcated Chalcogen Bonding and Hydrogen Bonding as Stereocontrolling Elements for Selective Strain-Release Septanosylation
Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype
RZZ-Spindly and CENP-E form an integrated platform to recruit dynein to the kinetochore corona
Structure of the native myosin filament in the relaxed cardiac sarcomere
Synthetic Matching of Complex Monoterpene Indole Alkaloid Chemical Space
Synthetic Matching of Complex Monoterpene Indole Alkaloid Chemical Space
Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments
Native Semisynthesis of Isopeptide-Linked Substrates for Specificity Analysis of Deubiquitinases and Ubl Proteases
Structural basis of mRNA binding by the human FERRY Rab5 effector complex
Programming inactive RNA-binding small molecules into bioactive degraders
Stable kinetochore-microtubule attachment requires loop-dependent Ndc80-Ndc80 binding
TomoTwin: generalized 3D localization of macromolecules in cryo-electron tomograms with structural data mining
Structural Biochemistry of Muscle Contraction
The EGFR phosphatase RPTPγ is a redox-regulated suppressor of promigratory signaling.
Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors
The structural flexibility of MAD1 facilitates the assembly of the Mitotic Checkpoint Complex
Morphological profiling identifies the motor protein Eg5 as cellular target of spirooxindoles
Ausgewählte Publikationen 2022
 A synergistic Rh(I)/organoboron-catalysed site-selective carbohydrate functionalization that involves multiple stereocontrol
A cryogenic, coincident fluorescence, electron and ion beam microscope
Structural basis of actin filament assembly and aging
Structural basis for specific inhibition of the deubiquitinase UCHL1
CRISPR screens in Drosophila cells identify Vsg as a Tc toxin receptor
Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin
Identification of a Novel Pseudo-Natural Product Type IV IDO1 Inhibitor Chemotype
Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector
Mechanism of threonine ADP-ribosylation of F-actin by a Tc toxin
Structure of the human inner kinetochore CCAN complex and its significance for human centromere organization
Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin
On the role of phase separation in the biogenesis of membraneless compartments
Structure of the Mon1-Ccz1 complex reveals molecular basis of membrane binding for Rab7 activation
Synthesis of 20-Membered Macrocyclic Pseudo-Natural Products Yields Inducers of LC3 Lipidation
Ausgewählte Publikationen 2021
Ultrarapid cryo-arrest of living cells on a microscope enables multiscale imaging of out-of-equilibrium molecular patterns
Targeted substrate loop insertion by VCP/p97 during PP1 complex disassembly
Small molecule modulation of the Drosophila Slo channel elucidated by cryo-EM
Molecular architecture of black widow spider neurotoxins
High-resolution structures of the actomyosin-V complex in three nucleotide states provide insights into the force generation mechanism.
 Mechanism of actin-dependent activation of nucleotidyl cyclase toxins from bacterial human pathogens
A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks
Dynamic Catalytic Highly Enantioselective 1,3-Dipolar Cycloadditions
Combination of pseudo-natural product design and formal natural product ring distortion yields stereochemically and biologically diverse pseudo-sesquiterpenoid alkaloids
Assembly principles and stoichiometry of a complete human kinetochore module
Growth factor–dependent ErbB vesicular dynamics couple receptor signaling to spatially and functionally distinct Erk pools
Natural product fragment combination to performance-diverse pseudo-natural products
The molecular basis for sarcomere organization in vertebrate skeletal muscle
A self-organized synthetic morphogenic liposome responds with shape changes to local light cues
Cell-Based Identification of New IDO1 Modulator Chemotypes
Cryo-EM resolves molecular recognition of an optojasp photoswitch bound to actin filaments in both switch states
Overlap of NatA and IAP substrates implicates N-terminal acetylation in protein stabilization
Exploiting non-covalent interactions in selective carbohydrate synthesis
Key Publications 2020
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