Dynamic Catalytic Highly Enantioselective 1,3-Dipolar Cycloadditions

Yildirim O, Grigalunas M, Brieger L, Strohmann C, Antonchick AP, Waldmann H (2021). Dynamic Catalytic Highly Enantioselective 1,3-Dipolar Cycloadditions. Angew Chem Int Ed Engl.


The Waldmann group describes the discovery of dynamic covalent enantioselective metal-complex-catalyzed 1,3-dipolar cycloaddition reactions.

The sceintists have developed a stereodivergent tandem synthesis of structurally and stereochemically complex molecules that generates eight stereocenters with high diastereo- and enantioselectivity through asymmetric reversible bond formation in a dynamic process in two consecutive Ag-catalyzed 1,3-dipolar cycloadditions of azomethine ylides with electron-poor olefins.

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