Development of a PDEδ targeting PROTAC that impairs lipid metabolism

Winzker M, Friese A, Koch U, Janning P, Ziegler S. Waldmann H (2019). Angew Chem Int Ed Engl

doi: 10.1002/anie.201913712.

The Waldmann group developed a new proteolysis targeting chimera (PROTAC) which efficiently and selectively reduced PDEδ levels in cells through induced proteasomal degradation. Its application increased sterol regulatory element binding protein (SREBP)-mediated gene expression of enzymes involved in lipid metabolism, which was accompanied by elevated levels of cholesterol precursors. This shows that PDEd function plays a role in the regulation of enzymes of the mevalonate pathway.
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