Development of a PDEδ targeting PROTAC that impairs lipid metabolism
Winzker M, Friese A, Koch U, Janning P, Ziegler S. Waldmann H (2019). Angew Chem Int Ed Engl
The Waldmann group developed a new proteolysis targeting chimera (PROTAC) which efficiently and selectively reduced PDEδ levels in cells through induced proteasomal degradation. Its application increased sterol regulatory element binding protein (SREBP)-mediated gene expression of enzymes involved in lipid metabolism, which was accompanied by elevated levels of cholesterol precursors. This shows that PDEd function plays a role in the regulation of enzymes of the mevalonate pathway.