Selected Publications 2019

SPHIRE-crYOLO is a fast and accurate fullyautomated particle picker for cryo-EM

SPHIRE-crYOLO is a fast and accurate fullyautomated particle picker for cryo-EM

Wagner T, Merino F, Stabrin S, Moriya T, Antoni C, Apelbau A, Hagel P, Sitsel O, Raisch T, Prumbaum D, Quentin D, Roderer D, Tacke S, Siebolds B, Schubert E, Shaikh TR, Lill P, Gatsogiannis C, Raunser S (2019). Communications Biology 

doi: doi.org/10.1038/s42003-019-0437. [more]
Development of a PDEδ targeting PROTAC that impairs lipid metabolism

Development of a PDEδ targeting PROTAC that impairs lipid metabolism

Winzker M, Friese A, Koch U, Janning P, Ziegler S. Waldmann H (2019). Angew Chem Int Ed Engl

doi: 10.1002/anie.201913712. [more]
<p>Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling</p>

Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling

Huis In 't Veld PJ, Volkov VA, Stender ID, Musacchio A, Dogterom M (2019). Elife

doi: 10.7554/eLife.49539. [more]
Towards the application of Tc toxins as a universal protein translocation system

Towards the application of Tc toxins as a universal protein translocation system

Roderer D, Schubert E, Sitsel O, Raunser S (2019). (2019). Nat Comms

doi: 10.1038/s41467-019-13253-8. [more]
<span>Image-based Morphological Profiling Identifies a Lysosomotropic, Iron-Sequestering Autophagy Inhibitor</span>

Image-based Morphological Profiling Identifies a Lysosomotropic, Iron-Sequestering Autophagy Inhibitor

Roderer D, Hofnagel O, Benz R, Raunser SLaraia L, Garivet G, Foley DJ, Kaiser N, Müller S, Zinken S, Pinkert T, Wilke J, Corkery D, Pahl A, Sievers S, Janning P, Arenz C, Wu Y, Rodriguez R, Waldmann H (2019). PNAS

doi: 10.1002/anie.201913712. [more]
<span>Structure of a Tc holotoxin pore provides insights into the translocation mechanism</span>

Structure of a Tc holotoxin pore provides insights into the translocation mechanism

Roderer D, Hofnagel O, Benz R, Raunser S (2019). PNAS

doi: 10.1073/pnas.1909821116. [more]
<span>Profilin and formin constitute a pacemaker system for robust actin filament growth</span>

Profilin and formin constitute a pacemaker system for robust actin filament growth

Funk J, Merino F, Venkova L, Heydenreich L, Kierfeld J, Vargas P, Raunser S, Piel M, Bieling P (2019). eLife

doi: 10.7554/eLife.50471 [more]
<span>Extraction of active RhoGTPases by RhoGDI regulates spatiotemporal patterning of RhoGTPases</span>

Extraction of active RhoGTPases by RhoGDI regulates spatiotemporal patterning of RhoGTPases

Gold AE, Visco I, Bieling P, Bement WM (2019). eLife

doi: 10.7554/eLife.50471 [more]
<p>Common architecture of Tc toxins from human and insect pathogenic bacteria</p>

Common architecture of Tc toxins from human and insect pathogenic bacteria

Leidreiter F, Roderer D, Meusch D, Gatsogiannis C, R. Benz R, Raunser S (2019). Science Advances

doi: 10.1126/sciadv.aax6497. [more]
<span>Cryo-EM structure of the ClpXP protein degradation machinery</span>

Cryo-EM structure of the ClpXP protein degradation machinery

Raisch T, Chang CT, Levdansky Y, Muthukumar S, Gatsogiannis C, Balogh D, Merino F, Sieber S, Raunser S (2019). Nat. Struct. Mol. Biol.

doi: 10.1038/s41594-019-0304-0. [more]
<span>Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing</span>

Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing

Pan D, Walstein K, Take A, Bier D, Kaiser N, Musacchio A (2019). Nature Communications

doi: 10.1038/s41467-019-12019-6. [more]
<span>Synthesis of Indomorphan Pseudo Natural Product Inhibitors of Glucose Transporters GLUT-1 and -3</span>

Synthesis of Indomorphan Pseudo Natural Product Inhibitors of Glucose Transporters GLUT-1 and -3

Ceballos J, Schwalfenberg M, Karageorgis G, Reckzeh ES, Sievers S, Ostermann C, Pahl A, Sellstedt M, Nowacki J, Carnero Corrales M, Wilke J, Laraia L, Tschapalda K, Metz M, Sehr DA, Brand S, Winklhofer K, Janning P, Ziegler S, Waldmann H (2019) Angew Chem Int Ed Engl

doi: 10.1002/anie.201909518. [more]
<span>Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß</span>

Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß

Kremer L, Hennes E, Brause A, Ursu A, Robke L, Matsubayashi HT, Nihongaki Y, Flegel J, Mejdrová I, Eickhoff J, Baumann M, Nencka R, Janning P, Kordes S, Schöler HR, Sterneckert J, Inoue T, Ziegler S, Waldmann H (2019). Angew Chem Int Ed Engl

doi: 10.1002/anie.201907632. [more]
<span>Design, Synthesis and Phenotypic Profiling of Pyrano-Furo-Pyridone Pseudo Natural Products</span>

Design, Synthesis and Phenotypic Profiling of Pyrano-Furo-Pyridone Pseudo Natural Products

Christoforow A, Wilke J, Binici A, Pahl A, Ostermann C, Sievers S, Waldmann H (2019). Angew Chem Int Ed Engl 

doi: 10.1002/anie.201907853. [more]
<span>Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation</span>

Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation

Raisch T, Chang CT, Levdansky Y, Muthukumar S, Raunser S, Valkov E (2019). Nature Communications

doi: 10.1038/s41467-019-11094-z. [more]
<span>The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis</span>

The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis

Laraia L, Friese A, Corkery Dp, Konstantinidis G, Erwin N, Hofer W, Karatas H, Klewer L, Brockmeyer A, Metz M, Schölermann
B, Dwivedi M, Li L, Rios-Munoz P, Köhn M, Winter R, Vetter IR, Ziegler S, Janning P, Wu YW and Waldmann H (2019).  Nat Chem Biol

 doi.org/10.1038/s41589-019-0307-5 [more]
Electroporated recombinant proteins as tools for in vivo functional complementation, imaging, and chemical biology

Electroporated recombinant proteins as tools for in vivo functional complementation, imaging, and chemical biology

Alex A, Piano V, Polley S, Stuiver M, Voss S, Ciossani G, Overlack K, Voss B, Wohlgemuth S, Petrovic A, Wu Y, Selenko P, Musacchio A, Maffini S (2019). Elife

 doi: 10.7554/eLife.48287 [more]
<span>Chemical genetics reveals a role of dCTP pyrophosphatase 1 in Wnt signaling</span>

Chemical genetics reveals a role of dCTP pyrophosphatase 1 in Wnt signaling

Friese A, Kapoor S, Schneidewind T, Vidadala SR, Sardana J, Brause A, Förster T, Bischoff M, Wagner J, Janning P, Ziegler S, Waldmann H (2019). Angwandte Chemie

doi: https://doi.org/10.1002/ejoc.201900586 [more]
The Pseudo Natural Product Myokinasib Is a Myosin Light Chain Kinase 1 Inhibitor with Unprecedented Chemotype

The Pseudo Natural Product Myokinasib Is a Myosin Light Chain Kinase 1 Inhibitor with Unprecedented Chemotype

Schneidewind T, Kapoor S, Garivet G, Karageorgis G, Narayan R, Vendrell-Navarro G, Antonchick AP, Ziegler S, Waldmann H (2019). Cell Chem Biol

doi: 10.1016/j.chembiol.2018.11.014. [more]
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