The Pseudo Natural Product Myokinasib Is a Myosin Light Chain Kinase 1 Inhibitor with Unprecedented Chemotype

Schneidewind T, Kapoor S, Garivet G, Karageorgis G, Narayan R, Vendrell-Navarro G, Antonchick AP, Ziegler S, Waldmann H (2019). Cell Chem Biol

doi: 10.1016/j.chembiol.2018.11.014.

The Waldmann lab developed the next pseudo Natural Product (NP) called Myokinasib, a de novo combination of two biosynthetically unrelated NP fragment types: indoles and tropanes.

Myokinasib is a truly unique chiral inhibitor of myosin light chain kinase 1 (MLCK1), impairs cytokinesis and induces formation of multinucleated cells.

Read hear about the first pseudo Natural Product (NP) developed by the Waldmann Lab: Nature 2.0 – Inspiring new drug discovery by pseudo natural products

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