Prof. Dr. Andrea Musacchio

Andrea Musacchio wurde am 11. Juli 1964 in Rom geboren. Er hat Biologie an der Tor Vergata Universität in Rom (1985-1990) studiert. Er hat von 1991 bis 1995 bei Matti Saraste am European Molecular Biology Laboratory (EMBL)/Universität Heidelberg seine Promotion abgelegt.  

Von 1995-1998 war er Postdoctoral Fellow an der Harvard Medical School in der Arbeitsgruppe von Stephen C. Harrison, bis er 1999 nach Italien als Gruppenleiter in das Department of Experimental Oncology des European Institute of Oncology in Mailand zurückkehrte. Dort wurde er 2006 als Professor berufen.  

Seit Januar 2011 ist er Direktor der Abteilung Mechanistische Zellbiologie am Max-Planck-Institut für molekulare Physiologie. 

Bis Januar 2017 war Andrea Musacchio Geschäftsführender Direktor. Er ist der Sprecher der International Max Planck Research School (IMPRS)


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Vita

Vollständige Vita  

Education

1985-90
Degree in Biology, University of Tor Vergata (summa cum laude), Rome, Italy,
Research advisor: Prof. Dr. Giovanni Cesareni

1991-95
PhD in Biochemistry, EMBL-University of Heidelberg (summa cum laude), Heidelberg, Germany
Research advisor: Dr. Matti Saraste

1995-98
Postdoctoral Fellow, Harvard Medical School, Boston, USA, 
Research advisor: Prof Stephen C. Harrison

Current Position(s)

 2011-now
Director, Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany

2012-now
Honorary Full Professor, University of Duisburg-Essen, Germany

Previous Position(s)

1999-03
Assistant Professor, Department of Experimental Oncology, European Institute of Oncology, Milan, Italy

2003-06
Associate Professor, Department of Experimental Oncology, European Institute of Oncology, Milan, Italy

2006-10
Full Professor, Department of Experimental Oncology, European Institute of Oncology, Milan, Italy

Fellowships and Awards

        • Human Frontier Science Program postdoctoral fellow (1995-1997)
        • American Cancer Society Senior postdoctoral fellow (1997-1998)
        • Scholar of the Italian Foundation for Cancer Research (1999-2004)
        • EMBO Young Investigator (2000-2004)
        • Chiara D’Onofrio Prize (2006)
        • Mendel Lecture 2008 (Brno, Czech Republic)
        • ERC Senior Investigator Grant Awardee (2008)
        • EMBO Member (since 2009)      

    Ausgewählte Publikationen 2013 - 2019

    Publikationsliste 10/2019   

    Pan D, Walstein K, Take A, Bier D, Kaiser N, Musacchio A (2019). Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing. Nature Communications
    doi: 10.1038/s41467-019-12019-6.

    Alex A, Piano V, Polley S, Stuiver M, Voss S, Ciossani G, Overlack K, Voss B, Wohlgemuth S, Petrovic A, Wu Y, Selenko P, Musacchio A, Maffini S (2019). Electroporated recombinant proteins as tools for in vivo functional complementation, imaging, and chemical biology. ELife
    doi: 10.7554/eLife.48287

    Pesenti ME, Prumbaum D, Auckland P, Smith CM, Faesen AC, Petrovic A, Erent M, Maffini S, Pentakota S, Weir JR, Lin YC, Raunser S, McAinsh AD, Musacchio A (2018). Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80. Mol Cell 
    doi: 10.1016/j.molcel.2018.07.038. 

    Mosalaganti S, Keller J, Altenfeld A, Winzker M, Rombaut P, Saur M, Petrovic A, Wehenkel A, Wohlgemuth S, Müller F, Maffini S, Bange T, Herzog F, Waldmann H, Raunser S & Musacchio A (2017). Structure of the RZZ complex and molecular basis of its interaction with Spindly. J Cell Bio 216(4):961-981
    doi: 10.1083/jcb.201611060.

    Faesen AC, Thanasoula M, Maffini S, Breit C, Müller F, van Gerwen S, Bange T, Musacchio A (2017). Basis of catalytic assembly of the mitotic checkpoint complex. Nature
    doi: 10.1038/nature21384.

    Pan D, Klare K, Petrovic A, Take A, Walstein K, Singh P, Rondelet A, Bird AW, Musacchio A (2017). CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading. eLife 6:e23352.
    doi: 10.7554/eLife.23352.

    Pan D, Klare K, Petrovic A, Take A, Walstein K, Singh P, Rondelet A, Bird AW, Musacchio A (2017). CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading. eLife 6:e23352.
    doi: 10.7554/eLife.23352.

    Huis In 't Veld PJ, Jeganathan S, Petrovic A, Singh P, John J, Krenn V, Weissmann F, Bange T, Musacchio A (2016). Molecular basis of outer kinetochore assembly on CENP-T. eLife 5:e21007.
    doi: 10.7554/eLife.21007.

    Petrovic A, Keller J, Liu Y, Overlack K, John J, Dimitrova YN, Jenni S, van Gerwen S, Stege P, Wohlgemuth S, Rombaut P, Herzog F, Harrison SC, Vetter IR, and Musacchio A (2016). Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores. Cell 167(4):1028-1040.e15.
    doi: http://dx.doi.org/10.1016/j.cell.2016.10.005.

    Weir JR, Faesen AC, Klare K, Petrovic A, Basilico F, Fischböck J, Pentakota S, Keller J, Pesenti ME, Pan D, Vogt D, Wohlgemuth S, Herzog F, Musacchio A (2016). Insights from biochemical reconstitution into the architecture of human kinetochores. Nature 537(7619):249-253.
    doi: 10.1038/nature19333.


    Klare K, Weir JR, Basilico F, Zimniak T, Massimiliano L, Ludwigs N, Herzog F & Musacchio A (2015). CENP-C is a blueprint for constitutive centromere-associated network assembly within human kinetochores. J Cell Biol 210:11-22.
    doi: 10.1083/jcb.201412028.

    Krenn V, Overlack K, Primorac I, van Gerwen S & Musacchio A (2014). KI motifs of human Knl1 enhance assembly of comprehensive spindle checkpoint complexes around MELT repeats. Curr Biol 24:29-39.
    doi: 10.1016/j.cub.2013.11.046.

    Basilico F, Maffini S, Weir JR, Prumbaum D, Rojas AM, Zimniak T, De Antoni A, Jeganathan S, Voss B, van Gerwen S, Krenn V, Massimiliano L, Valencia A, Vetter IR, Herzog F, Raunser S, Pasqualato S & Musacchio A (2014). The pseudo GTPase CENP-M drives human kinetochore assembly. Elife 8:e02978.
    doi: 10.7554/eLife.02978.

    Petrovic A, Mosalaganti S, Keller J, Mattiuzzo M, Overlack K, Krenn V, De Antoni A, Wohlgemuth S, Cecatiello V, Pasqualato S, Raunser S & Musacchio A (2014). Modular Assembly of RWD Domains on the Mis12 Complex Underlies Outer Kinetochore Organization. Mol Cell 53:591-605.
    doi: 10.1016/j.molcel.2014.01.019.

    Primorac I, Weir JR, Chiroli E, Gross F, Hoffmann I, van Gerwen S, Ciliberto A & Musacchio A (2013). Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signalling. Elife 2:e01030.
    doi: 10.7554/eLife.01030.

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