Prof. Dr. Andrea Musacchio

Andrea Musacchio was born on July 11, 1964 in Rome. He studied biology at the Tor Vergata University in Rome (1985-1990). From 1991 to 1995 he earned his doctorate under the supervision of Matti Saraste at the European Molecular Biology Laboratory (EMBL)/University of Heidelberg.

From 1995-1998 he was a postdoctoral fellow at the Harvard Medical School in the research group of Stephen C. Harrison before returning to Italy in 1999 to become a group leader in the Department of Experimental Oncology of the European Institute of Oncology in in Milan. There he was appointed professor in 2006. In 2009, he was elected as a member of the European Molecular Biology Organisation (EMBO).


Since January 2011 he has been the director of the Department of Mechanistic Cell Biology at the Max Planck Institute of Molecular Physiology.

Since 2012 he has been an honorary professor at the University of Duisburg-Essen. In 2009, he was elected a member of the European Molecular Biology Organization (EMBO). He has received two ERC Advanced Grants (2009 and 2015) and a ERC Synergy Grant (2020). 2020 he took over the chair of the Max Planck Society's Biology and Medicine Section.

For his groundbreaking structural biology work on the distribution of chromosomes during cell division he was honored with the Gottfried Wilhelm Leibniz Prize 2020, the highest scientific award in Germany.

 

Vita

Complete CV 

Education

1985-90
Degree in Biology, University of Tor Vergata (summa cum laude), Rome, Italy,
Research advisor: Prof. Dr. Giovanni Cesareni

1991-95
PhD in Biochemistry, EMBL-University of Heidelberg (summa cum laude), Heidelberg, Germany
Research advisor: Dr. Matti Saraste

1995-98
Postdoctoral Fellow, Harvard Medical School, Boston, USA, 
Research advisor: Prof Stephen C. Harrison

Current Position(s)

 2011-now
Director, Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany

2012-now
Honorary Full Professor, University of Duisburg-Essen, Germany

Previous Position(s)

1999-03
Assistant Professor, Department of Experimental Oncology, European Institute of Oncology, Milan, Italy

2003-06
Associate Professor, Department of Experimental Oncology, European Institute of Oncology, Milan, Italy

2006-10
Full Professor, Department of Experimental Oncology, European Institute of Oncology, Milan, Italy

Fellowships and Awards

        • Human Frontier Science Program postdoctoral fellow (1995-1997)
        • American Cancer Society Senior postdoctoral fellow (1997-1998)
        • Scholar of the Italian Foundation for Cancer Research (1999-2004)
        • EMBO Young Investigator (2000-2004)
        • Chiara D’Onofrio Prize (2006)
        • Mendel Lecture 2008 (Brno, Czech Republic)
        • ERC Senior Investigator Grant Awardee (2008)
        • EMBO Member (since 2009)      
        • Gottfried Wilhelm Leibniz Pricewinner 2020

    Ausgewählte Publikationen 2013 - 2022

    PubMed List>
    Publication list 05/2022 as PDF 

    Pesenti ME, Raisch T, Conti D, Walstein K, Hoffmann I, Vogt D, Prumbaum D, Vetter IR, Raunser S, Musacchio A (2022). Structure of the human inner kinetochore CCAN complex and its significance for human centromere organization. Mol Cell
    Source

    Raisch T, Ciossani G, d'Amico E, Cmentowski V, Carmignani S, Maffini S, Merino F, Wohlgemuth S, Vetter IR, Raunser S, Musacchio A (2022). Structure of the RZZ complex and molecular basis of Spindly-driven corona assembly at human kinetochores. EMBO J
    Source

    Piano V, Alex A, Stege P, Maffini S, Stoppiello GA, Huis In 't Veld PJ, Vetter IR, Musacchio A (2021). CDC20 assists its catalytic incorporation in the mitotic checkpoint complex.  Science
    Source

    Pan D, Walstein K, Take A, Bier D, Kaiser N, Musacchio A (2019). Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing. Nature Communications
    doi: 10.1038/s41467-019-12019-6.

    Alex A, Piano V, Polley S, Stuiver M, Voss S, Ciossani G, Overlack K, Voss B, Wohlgemuth S, Petrovic A, Wu Y, Selenko P, Musacchio A, Maffini S (2019). Electroporated recombinant proteins as tools for in vivo functional complementation, imaging, and chemical biology. ELife
    doi: 10.7554/eLife.48287

    Pesenti ME, Prumbaum D, Auckland P, Smith CM, Faesen AC, Petrovic A, Erent M, Maffini S, Pentakota S, Weir JR, Lin YC, Raunser S, McAinsh AD, Musacchio A (2018). Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80. Mol Cell 
    doi: 10.1016/j.molcel.2018.07.038. 

    Mosalaganti S, Keller J, Altenfeld A, Winzker M, Rombaut P, Saur M, Petrovic A, Wehenkel A, Wohlgemuth S, Müller F, Maffini S, Bange T, Herzog F, Waldmann H, Raunser S & Musacchio A (2017). Structure of the RZZ complex and molecular basis of its interaction with Spindly. J Cell Bio 216(4):961-981
    doi: 10.1083/jcb.201611060.

    Faesen AC, Thanasoula M, Maffini S, Breit C, Müller F, van Gerwen S, Bange T, Musacchio A (2017). Basis of catalytic assembly of the mitotic checkpoint complex. Nature
    doi: 10.1038/nature21384.

    Pan D, Klare K, Petrovic A, Take A, Walstein K, Singh P, Rondelet A, Bird AW, Musacchio A (2017). CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading. eLife 6:e23352.
    doi: 10.7554/eLife.23352.

    Pan D, Klare K, Petrovic A, Take A, Walstein K, Singh P, Rondelet A, Bird AW, Musacchio A (2017). CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading. eLife 6:e23352.
    doi: 10.7554/eLife.23352.

    Huis In 't Veld PJ, Jeganathan S, Petrovic A, Singh P, John J, Krenn V, Weissmann F, Bange T, Musacchio A (2016). Molecular basis of outer kinetochore assembly on CENP-T. eLife 5:e21007.
    doi: 10.7554/eLife.21007.

    Petrovic A, Keller J, Liu Y, Overlack K, John J, Dimitrova YN, Jenni S, van Gerwen S, Stege P, Wohlgemuth S, Rombaut P, Herzog F, Harrison SC, Vetter IR, and Musacchio A (2016). Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores. Cell 167(4):1028-1040.e15.
    doi: http://dx.doi.org/10.1016/j.cell.2016.10.005.

    Weir JR, Faesen AC, Klare K, Petrovic A, Basilico F, Fischböck J, Pentakota S, Keller J, Pesenti ME, Pan D, Vogt D, Wohlgemuth S, Herzog F, Musacchio A (2016). Insights from biochemical reconstitution into the architecture of human kinetochores. Nature 537(7619):249-253.
    doi: 10.1038/nature19333.

    Klare K, Weir JR, Basilico F, Zimniak T, Massimiliano L, Ludwigs N, Herzog F & Musacchio A (2015). CENP-C is a blueprint for constitutive centromere-associated network assembly within human kinetochores. J Cell Biol 210:11-22.
    doi: 10.1083/jcb.201412028.

    Krenn V, Overlack K, Primorac I, van Gerwen S & Musacchio A (2014). KI motifs of human Knl1 enhance assembly of comprehensive spindle checkpoint complexes around MELT repeats. Curr Biol 24:29-39.
    doi: 10.1016/j.cub.2013.11.046.

    Basilico F, Maffini S, Weir JR, Prumbaum D, Rojas AM, Zimniak T, De Antoni A, Jeganathan S, Voss B, van Gerwen S, Krenn V, Massimiliano L, Valencia A, Vetter IR, Herzog F, Raunser S, Pasqualato S & Musacchio A (2014). The pseudo GTPase CENP-M drives human kinetochore assembly. Elife 8:e02978.
    doi: 10.7554/eLife.02978.

    Petrovic A, Mosalaganti S, Keller J, Mattiuzzo M, Overlack K, Krenn V, De Antoni A, Wohlgemuth S, Cecatiello V, Pasqualato S, Raunser S & Musacchio A (2014). Modular Assembly of RWD Domains on the Mis12 Complex Underlies Outer Kinetochore Organization. Mol Cell 53:591-605.
    doi: 10.1016/j.molcel.2014.01.019.

    Primorac I, Weir JR, Chiroli E, Gross F, Hoffmann I, van Gerwen S, Ciliberto A & Musacchio A (2013). Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signalling. Elife 2:e01030.
    doi: 10.7554/eLife.01030.

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