Andrea Musacchio was born on July 11, 1964 in Rome. He studied biology at the Tor Vergata University in Rome (1985-1990). From 1991 to 1995 he earned his doctorate under the supervision of Matti Saraste at the European Molecular Biology Laboratory (EMBL)/University of Heidelberg.
From 1995-1998 he was a postdoctoral fellow at the Harvard Medical School in the research group of Stephen C. Harrison before returning to Italy in 1999 to become a group leader in the Department of Experimental Oncology of the European Institute of Oncology in in Milan. There he was appointed professor in 2006.
Since January 2011 he has been the director of the Department of Mechanistic Cell Biology at the Max Planck Institute of Molecular Physiology.
Until January 2017 Andrea Musacchio has been managing director. He is also speaker of the
List of Publications 10/2018 
Selected Publications 2013 - 2018
Pesenti ME, Prumbaum D, Auckland P, Smith CM, Faesen AC, Petrovic A, Erent M, Maffini S, Pentakota S, Weir JR, Lin YC, Raunser S, McAinsh AD, Musacchio A (2018).
Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80.
Mol Cell
doi: 10.1016/j.molcel.2018.07.038.
Volkov VA, Huis In 't Veld PJ, Dogterom M, Musacchio A. (2018).
Multivalency of NDC80 in the outer kinetochore is essential to track shortening microtubules and generate forces.
eLife
doi: 10.7554/eLife.36764
Mosalaganti S, Keller J, Altenfeld A, Winzker M, Rombaut P, Saur M, Petrovic A, Wehenkel A, Wohlgemuth S, Müller F, Maffini S, Bange T, Herzog F, Waldmann H, Raunser S & Musacchio A (2017).
Structure of the RZZ complex and molecular basis of its interaction with Spindly.
J Cell Bio 216(4):961-981
doi: 10.1083/jcb.201611060.
Faesen AC, Thanasoula M, Maffini S, Breit C, Müller F, van Gerwen S, Bange T, Musacchio A (2017).
Basis of catalytic assembly of the mitotic checkpoint complex.
Nature
doi: 10.1038/nature21384.
Pan D, Klare K, Petrovic A, Take A, Walstein K, Singh P, Rondelet A, Bird AW, Musacchio A (2017).
CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading.
eLife 6:e23352.
doi: 10.7554/eLife.23352.
Pan D, Klare K, Petrovic A, Take A, Walstein K, Singh P, Rondelet A, Bird AW, Musacchio A (2017).
CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading.
eLife 6:e23352.
doi: 10.7554/eLife.23352.
Huis In 't Veld PJ, Jeganathan S, Petrovic A, Singh P, John J, Krenn V, Weissmann F, Bange T, Musacchio A (2016).
Molecular basis of outer kinetochore assembly on CENP-T.
eLife 5:e21007.
doi: 10.7554/eLife.21007.
Petrovic A, Keller J, Liu Y, Overlack K, John J, Dimitrova YN, Jenni S, van Gerwen S, Stege P, Wohlgemuth S, Rombaut P, Herzog F, Harrison SC, Vetter IR, and Musacchio A (2016).
Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores.
Cell 167(4):1028-1040.e15.
doi: http://dx.doi.org/10.1016/j.cell.2016.10.005.
Weir JR, Faesen AC, Klare K, Petrovic A, Basilico F, Fischböck J, Pentakota S, Keller J, Pesenti ME, Pan D, Vogt D, Wohlgemuth S, Herzog F, Musacchio A (2016).
Insights from biochemical reconstitution into the architecture of human kinetochores.
Nature 537(7619):249-253.
doi: 10.1038/nature19333.
Klare K, Weir JR, Basilico F, Zimniak T, Massimiliano L, Ludwigs N, Herzog F & Musacchio A (2015).
CENP-C is a blueprint for constitutive centromere-associated network assembly within human kinetochores. J Cell Biol 210:11-22.
doi: 10.1083/jcb.201412028.
Krenn V, Overlack K, Primorac I, van Gerwen S & Musacchio A (2014).
KI motifs of human Knl1 enhance assembly of comprehensive spindle checkpoint complexes around MELT repeats. Curr Biol 24:29-39.
doi: 10.1016/j.cub.2013.11.046.
Basilico F, Maffini S, Weir JR, Prumbaum D, Rojas AM, Zimniak T, De Antoni A, Jeganathan S, Voss B, van Gerwen S, Krenn V, Massimiliano L, Valencia A, Vetter IR, Herzog F, Raunser S, Pasqualato S & Musacchio A (2014).
The pseudo GTPase CENP-M drives human kinetochore assembly. Elife 8:e02978.
doi: 10.7554/eLife.02978.
Petrovic A, Mosalaganti S, Keller J, Mattiuzzo M, Overlack K, Krenn V, De Antoni A, Wohlgemuth S, Cecatiello V, Pasqualato S, Raunser S & Musacchio A (2014).
Modular Assembly of RWD Domains on the Mis12 Complex Underlies Outer Kinetochore Organization. Mol Cell 53:591-605.
doi: 10.1016/j.molcel.2014.01.019.
Primorac I, Weir JR, Chiroli E, Gross F, Hoffmann I, van Gerwen S, Ciliberto A & Musacchio A (2013).
Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signalling. Elife 2:e01030.
doi: 10.7554/eLife.01030.
