Prof. Dr. Andrea Musacchio
Andrea Musacchio was born on July 11, 1964 in Rome. He studied biology at the Tor Vergata University in Rome (1985-1990). From 1991 to 1995 he earned his doctorate under the supervision of Matti Saraste at the European Molecular Biology Laboratory (EMBL)/University of Heidelberg.
From 1995-1998 he was a postdoctoral fellow at the Harvard Medical School in the research group of Stephen C. Harrison before returning to Italy in 1999 to become a group leader in the Department of Experimental Oncology of the European Institute of Oncology in in Milan. There he was appointed professor in 2006.
Since January 2011 he has been the director of the Department of Mechanistic Cell Biology at the Max Planck Institute of Molecular Physiology.
Until January 2017 Andrea Musacchio has been managing director. He is also speaker of the International Max Planck Research School (IMPRS).
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Vita
Education
1985-90
Degree in Biology, University of Tor Vergata (summa cum laude), Rome, Italy,
Research advisor: Prof. Dr. Giovanni Cesareni
1991-95
PhD in Biochemistry, EMBL-University of Heidelberg (summa cum laude), Heidelberg, Germany
Research advisor: Dr. Matti Saraste
1995-98
Postdoctoral Fellow, Harvard Medical School, Boston, USA,
Research advisor: Prof Stephen C. Harrison
Current Position(s)
2011-now
Director, Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany
2012-now
Honorary Full Professor, University of Duisburg-Essen, Germany
Previous Position(s)
1999-03
Assistant Professor, Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
2003-06
Associate Professor, Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
2006-10
Full Professor, Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
Fellowships and Awards
- Human Frontier Science Program postdoctoral fellow (1995-1997)
- American Cancer Society Senior postdoctoral fellow (1997-1998)
- Scholar of the Italian Foundation for Cancer Research (1999-2004)
- EMBO Young Investigator (2000-2004)
- Chiara D’Onofrio Prize (2006)
- Mendel Lecture 2008 (Brno, Czech Republic)
- ERC Senior Investigator Grant Awardee (2008) EMBO Member (since 2009)
Ausgewählte Publikationen 2013 - 2019
Pan D, Walstein K, Take A, Bier D, Kaiser N, Musacchio A (2019). Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing. Nature Communications
doi: 10.1038/s41467-019-12019-6.
Alex A, Piano V, Polley S, Stuiver M, Voss S, Ciossani G, Overlack K, Voss B, Wohlgemuth S, Petrovic A, Wu Y, Selenko P, Musacchio A, Maffini S (2019). Electroporated recombinant proteins as tools for in vivo functional complementation, imaging, and chemical biology. ELife
doi: 10.7554/eLife.48287
Pesenti ME, Prumbaum D, Auckland P, Smith CM, Faesen AC, Petrovic A, Erent M, Maffini S, Pentakota S, Weir JR, Lin YC, Raunser S, McAinsh AD, Musacchio A (2018). Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80. Mol Cell
doi: 10.1016/j.molcel.2018.07.038.
Mosalaganti S, Keller J, Altenfeld A, Winzker M, Rombaut P, Saur M, Petrovic A, Wehenkel A, Wohlgemuth S, Müller F, Maffini S, Bange T, Herzog F, Waldmann H, Raunser S & Musacchio A (2017). Structure of the RZZ complex and molecular basis of its interaction with Spindly. J Cell Bio 216(4):961-981
doi: 10.1083/jcb.201611060.
Faesen AC, Thanasoula M, Maffini S, Breit C, Müller F, van Gerwen S, Bange T, Musacchio A (2017). Basis of catalytic assembly of the mitotic checkpoint complex. Nature
doi: 10.1038/nature21384.
Pan D, Klare K, Petrovic A, Take A, Walstein K, Singh P, Rondelet A, Bird AW, Musacchio A (2017). CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading. eLife 6:e23352.
doi: 10.7554/eLife.23352.
Pan D, Klare K, Petrovic A, Take A, Walstein K, Singh P, Rondelet A, Bird AW, Musacchio A (2017). CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading. eLife 6:e23352.
doi: 10.7554/eLife.23352.
Huis In 't Veld PJ, Jeganathan S, Petrovic A, Singh P, John J, Krenn V, Weissmann F, Bange T, Musacchio A (2016). Molecular basis of outer kinetochore assembly on CENP-T. eLife 5:e21007.
doi: 10.7554/eLife.21007.
Petrovic A, Keller J, Liu Y, Overlack K, John J, Dimitrova YN, Jenni S, van Gerwen S, Stege P, Wohlgemuth S, Rombaut P, Herzog F, Harrison SC, Vetter IR, and Musacchio A (2016). Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores. Cell 167(4):1028-1040.e15.
doi: http://dx.doi.org/10.1016/j.cell.2016.10.005.
Weir JR, Faesen AC, Klare K, Petrovic A, Basilico F, Fischböck J, Pentakota S, Keller J, Pesenti ME, Pan D, Vogt D, Wohlgemuth S, Herzog F, Musacchio A (2016). Insights from biochemical reconstitution into the architecture of human kinetochores. Nature 537(7619):249-253.
doi: 10.1038/nature19333.
Klare K, Weir JR, Basilico F, Zimniak T, Massimiliano L, Ludwigs N, Herzog F & Musacchio A (2015). CENP-C is a blueprint for constitutive centromere-associated network assembly within human kinetochores. J Cell Biol 210:11-22.
doi: 10.1083/jcb.201412028.
Krenn V, Overlack K, Primorac I, van Gerwen S & Musacchio A (2014). KI motifs of human Knl1 enhance assembly of comprehensive spindle checkpoint complexes around MELT repeats. Curr Biol 24:29-39.
doi: 10.1016/j.cub.2013.11.046.
Basilico F, Maffini S, Weir JR, Prumbaum D, Rojas AM, Zimniak T, De Antoni A, Jeganathan S, Voss B, van Gerwen S, Krenn V, Massimiliano L, Valencia A, Vetter IR, Herzog F, Raunser S, Pasqualato S & Musacchio A (2014). The pseudo GTPase CENP-M drives human kinetochore assembly. Elife 8:e02978.
doi: 10.7554/eLife.02978.
Petrovic A, Mosalaganti S, Keller J, Mattiuzzo M, Overlack K, Krenn V, De Antoni A, Wohlgemuth S, Cecatiello V, Pasqualato S, Raunser S & Musacchio A (2014). Modular Assembly of RWD Domains on the Mis12 Complex Underlies Outer Kinetochore Organization. Mol Cell 53:591-605.
doi: 10.1016/j.molcel.2014.01.019.
Primorac I, Weir JR, Chiroli E, Gross F, Hoffmann I, van Gerwen S, Ciliberto A & Musacchio A (2013). Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signalling. Elife 2:e01030.
doi: 10.7554/eLife.01030.