Publikationen von Alfred Wittinghofer

Ismail, S. A.; Chen, Y.-X.; Miertzschke, M.; Vetter, I. R.; Koerner, C.; Wittinghofer, A.: Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119. The EMBO Journal 31 (20), 1, S. 4085 - 4094 (2012)

Gilsbach, B. K.; Ho, F. Y.; Vetter, I. R.; Van Haastert, P. J. M.; Wittinghofer, A.; Kortholt, A.: Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations. Proceedings of the National Academy of Sciences of the United States of America 109 (26), 1, S. 10322 - 10327 (2012)

Chandra, A.; Grecco, H. E.; Pisupati, V.; Perera, D.; Cassidy, L.; Skoulidis, F.; Ismail, S. A.; Hedberg, C.; Hanzal-Bayer, M.; Venkitaraman, A. R. et al.; Wittinghofer, A.; Bastiaens, P. I. H.: The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins. Nature Cell Biology 14, 1, S. 148 - 158 (2012)

Mucha, E.; Fricke, I.; Schaefer, A.; Wittinghofer, A.; Berken, A.: Rho proteins of plants - Functional cycle and regulation of cytoskeletal dynamics. European Journal of Cell Biology 90 (11), 1, S. 934 - 943 (2011)

Ismail, S. A.; Chen, Y.-X.; Rusinova, A.; Chandra, A.; Bierbaum, M.; Gremer, L.; Triola, G.; Waldmann, H.; Bastiaens, P. I. H.; Wittinghofer, A.: Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. Nature Chemical Biology 7, 1, S. 942 - 949 (2011)

Schaefer, A.; Miertzschke, M.; Berken, A.; Wittinghofer, A.: Dimeric Plant RhoGAPs Are Regulated by Its CRIB Effector Motif to Stimulate a Sequential GTP Hydrolysis. Journal of Molecular Biology 411 (4), 1, S. 808 - 822 (2011)

Miertzschke, M.; Koerner, C.; Vetter, I. R.; Keilberg, D.; Hot, E.; Leonardy, S.; Søgaard-Andersen, L.; Wittinghofer, A.: Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity. The EMBO Journal 30 (20), 1, S. 4185 - 4197 (2011)

Schaefer, A.; Höhner, K.; Berken, A.; Wittinghofer, A.: The unique plant RhoGAPs are dimeric and contain a CRIB motif required for affinity and specificity towards cognate small G proteins. Biopolymers 95, Preprint, S. 1 - 39 (2011)

Wittinghofer, A.; Vetter, I. R.: Structure-Function Relationships of the G Domain, a Canonical Switch Motif. Annual Review of Biochemistry 80, 1, S. 943 - 971 (2011)

Zent, E.; Vetter, I.; Wittinghofer, A.: Structural and biochemical properties of Sept7, a unique septin required for filament formation. Biological Chemistry 392 (8-9), 1, S. 791 - 797 (2011)

Gasper, R.; Sot, B.; Wittinghofer, A.: GTPase activity of Di-Ras proteins is stimulated by Rap1GAP proteins. Small Gtpases 1 (3), 1, S. 133 - 141 (2010)

Machaidze, G.; Sokoll, A.; Shimada, A.; Lustig, A.; Mazur, A.; Wittinghofer, A.; Aebi, U.; Mannherz, H. G.: Actin Filament Bundling and Different Nucleating Effects of Mouse Diaphanous-Related Formin FH2 Domains on Actin/ADF and Actin/Cofilin Complexes. Journal of Molecular Biology 403 (5), 1, S. 529 - 545 (2010)

Gremer, L.; Merbitz-Zahradnik, T.; Dvorsky, R.; Cirstea, I. C.; Kratz, C. P.; Zenker, M.; Wittinghofer, A.; Ahmadian, M. R.: Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders. Human Mutation 32 (1), 1, S. 33 - 43 (2010)

Chen, Y.-X.; Koch, S.; Uhlenbrock, K.; Weise, K.; Das, D.; Gremer, L.; Brunsveld, L.; Wittinghofer, A.; Winter, R.; Triola, G. et al.; Waldmann, H.: Synthesis of the Rheb and K-Ras4B GTPases. Angewandte Chemie International Edition 49 (35), 1, S. 6090 - 6095 (2010)

Böhme, S.; Meyer, S.; Krüger, A.; Steinhoff, H.-J.; Wittinghofer, A.; Klare, J. P.: Stabilization of G Domain Conformations in the tRNA-modifying MnmE-GidA Complex Observed with Double Electron Electron Resonance Spectroscopy. Journal of Biological Chemistry 285 (22), 1, S. 16991 - 17000 (2010)

Ismail, S. A.; Vetter, I. R.; Sot, B.; Wittinghofer, A.: The Structure of an Arf-ArfGAP Complex Reveals a Ca²⁺ Regulatory Mechanism. Cell 141 (5), 1, S. 812 - 821 (2010)

Kortholt, A.; Bolourani, P.; Rehmann, H.; Keizer-Gunnink, I.; Weeks, G.; Wittinghofer, A.; Van Haastert, P. J. M.: A Rap/Phosphatidylinositol 3-Kinase Pathway Controls Pseudopod Formation. Molecular Biology of the Cell 21 (6), 1, S. 936 - 945 (2010)

Chen, Y.-X.; Koch, S.; Uhlenbrock, K.; Weise, K.; Das, D.; Gremer, L.; Brunsveld, L.; Wittinghofer, A.; Winter, R.; Triola, G. et al.; Waldmann, H.: Synthesis of the Rheb and K-Ras4B GTPases. Angewandte Chemie 122 (35), 1, S. 6226 - 6231 (2010)

Cirstea, I. C.; Kutsche, K.; Dvorsky, R.; Gremer, L.; Carta, C.; Horn, D.; Roberts, A. E.; Lepri, F.; Merbitz-Zahradnik, T.; König, R. et al.; Kratz, C. P.; Pantaleoni, F.; Dentici, M. L.; Joshi, V. A.; Kucherlapati, R. S.; Mazzanti, L.; Mundlos, S.; Patton, M. A.; Silengo, M. C.; Rossi, C.; Zampino, G.; Digilio, C.; Stuppia, L.; Seemanova, E.; Pennacchio, L. A.; Gelb, B. D.; Dallapiccola, B.; Wittinghofer, A.; Ahmadian, M. R.; Tartaglia, M.; Zenker, M.: A restricted spectrum of NRAS mutations causes Noonan syndrome. Nature Genetics 42 (1), 1, S. 27 - 29 (2010)

Leonardy, S.; Miertzschke, M.; Bulyha, I.; Sperling, E.; Wittinghofer, A.; Søgaard-Andersen, L.: Regulation of dynamic polarity switching in bacteria by a Ras-like G-proein and its cognate GAP. EMBO Journal 29 (14), 1, S. 2276 - 2289 (2010)