Publikationen von Alfred Wittinghofer

Fansa, E. K.; Kösling, S. K.; Zent, E.; Wittinghofer, A.; Ismail, S.: PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity. Nature Communications 7, 11366, S. 1 - 9 (2016)

Hobbs , G. A.; Wittinghofer, A.; Der, C. J.: Selective Targeting of the KRAS G12C Mutant: Kicking KRAS When It's Down. Cancer Cell 29 (3), S. 251 - 253 (2016)

Fansa, E. K.; Wittinghofer, A.: Sorting of lipidated cargo by the Arl2/Arl3 system. Small GTPases 7 (4), S. 222 - 230 (2016)

Murarka, S.; Martín-Gago, P.; Schultz-Fademrecht, C.; Al Saabi, A.; Baumann, M.; Fansa, E. K.; Ismail, S.; Nussbaumer, P.; Wittinghofer, A.; Waldmann, H.: Development of Pyridazinone Chemotypes Targeting the PDEδ Prenyl Binding Site. Chemistry – A European Journal 23 (25), S. 6083 - 6093 (2016)

Fansa, E. K.; O’Reilly, N. J.; Ismail, S.; Wittinghofer, A.: The N- and C-terminal ends of RPGR can bind to PDE6δ. EMBO Reports 16 (12), S. 1583 - 1585 (2015)

Gotthardt, K.; Lokaj, M.; Koerner, C.; Falk, N.; Gießl, A.; Wittinghofer, A.: A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins. eLife, S. e11859:1 - e11859:28 (2015)

Lokaj, M.; Kösling, S. K.; Koerner, C.; Lange, S. M.; van Beersum, S. E.C.; van Reeuwijk, J.; Roepman, R.; Horn, N.; Ueffing, M.; Boldt, K. et al.; Wittinghofer, A.: The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function. Structure 23 (11), S. 2122 - 2132 (2015)

Kapoor, S.; Fansa, E. K.; Möbitz, S.; Ismail, S.; Winter, R.; Wittinghofer, A.; Weise, K.: Effect of the N-Terminal Helix and Nucleotide Loading on the Membrane and Effector Binding of Arl2/3. Biophysical Journal 109 (8), S. 1619 - 1629 (2015)

Rudi, K.; Ho, F. Y.; Gilsbach, B. K.; Pots, H.; Wittinghofer, A.; Kortholt, A.; Klare, J. P.: Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations. Bioscience Reports 35 (5), S. e00254:1 - e00254:12 (2015)

Gilsbach, B. K.; Messias, A. C.; Ito, G.; Sattler, M.; Alessi, D. R.; Wittinghofer, A.; Kortholt, A.: Structural Characterization of LRRK2 Inhibitors. Journal of Medicinal Chemistry 58 (9), S. 3751 - 3756 (2015)

Terheyden, S.; Ho, F. Y.; Gilsbach, B.; Wittinghofer, A.; Kortholt, A.: Revisiting the Roco G-protein cycle. Biochemical Journal 465 (1), S. 139 - 147 (2015)

Remans, K.; Bürger, M.; Vetter, I. R.; Wittinghofer, A.: C2 Domains as Protein-Protein Interaction Modules in the Ciliary Transition Zone. Cell Reports 8 (1), S. 1 - 9 (2014)

Zimmermann, G.; Schultz-Fademrecht, C.; Küchler, P.; Murarka, S.; Ismail, S.; Triola, G.; Nussbaumer, P.; Wittinghofer, A.; Waldmann, H.: Structure Guided Design and Kinetic Analysis of Highly Potent Benzimidazole Inhibitors Targeting the PDEδ Prenyl Binding Site. Journal of Medicinal Chemistry 57 (12), S. 5435 - 5448 (2014)

Zent, E.; Wittinghofer, A.: Human septin isoforms and the GDP-GTP cycle. Biological Chemistry 395 (2), S. 169 - 180 (2014)

Bravo-Rodriguez, K.; Ismail-Ali, A. F.; Klopries, S.; Kushnir, S.; Ismail, S.; Fansa, E. K.; Wittinghofer, A.; Schulz, F.; Sanchez-Garcia, E.: Predicted incorporation of non-native substrates by a polyketide synthase yields bioactive natural product derivatives. ChemBioChem: A European Journal of Chemical Biology 15 (13), S. 1991 - 1997 (2014)

Miertzschke, M.; Koerner, C.; Spoerner, M.; Wittinghofer, A.: Structural insights into the small G protein Arl13B and implications for Joubert syndrome. Biochemical Journal 457 (2), S. 301 - 311 (2014)

Wittinghofer, A.; Baum, J.; Blacklow, S.: Introductory editorial for the proteins special issue of biopolymers. Biopolymers 99 (11), S. 807 - 808 (2013)

Zimmermann, G.; Papke, B.; Ismail, S.; Vartak, N.; Chandra, A.; Hoffmann, M.; Hahn, S. A.; Triola, G.; Wittinghofer, A.; Bastiaens, P. I. H. et al.; Waldmann, H.: Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature 497 (7451), 1, S. 638 - 642 (2013)

Wätzlich, D.; Vetter, I. R.; Gotthardt, K.; Miertzschke, M.; Chen, Y.-X.; Wittinghofer, A.; Ismail, S.: The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo. EMBO Reports 14 (5), 1, S. 465 - 472 (2013)

Sot, B.; Behrmann, E.; Raunser, S.; Wittinghofer, A.: Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes. Proceedings of the National Academy of Sciences of the United States of America 110 (1), 1, S. 111 - 116 (2013)