Philippe Bastiaens

Philippe Bastiaens

Direktor, Systemische Zellbiologie


PubMed Liste>
Publikationsliste 01/2024  


Joshi MS, Stanoev A, Huebinger J, Soetje B, Zorina V, Roßmannek L, Michel K, Müller SA, Bastiaens PI (2023).The EGFR phosphatase RPTPγ is a redox-regulated suppressor of promigratory signaling.  EMBO J. Quelle


Huebinger J, Grecco H, Masip ME, Christmann J, Fuhr GR, Bastiaens PIH (2021).Ultrarapid cryo-arrest of living cells on a microscope enables multiscale imaging of out-of-equilibrium molecular patterns.  Science Advances

Brüggemann Y, Karajannis LS, Stanoev A, Stallaert W, Bastiaens PIH (2021).Growth factor–dependent ErbB vesicular dynamics couple receptor signaling to spatially and functionally distinct Erk pools  Science Signaling

Schmick M, Bastiaens PIH (2021).Understanding Ras Spatial Cycles Through Reaction-Diffusion Simulations  Methods Mol Biol

Gavriljuk K, Scocozza B, Ghasemalizadeh F, Seidel H, Nandan AP, Campos-Medina M, Schmick M, Koseska A & Bastiaens PIH (2021). A self-organized synthetic morphogenic liposome responds with shape changes to local light cues.  Nature Communications

ZUgehörige Publikation:

Dehmelt L & Bastiaens PIH (2010). Spatial organization of intracellular communication: insights from imaging. Nat Rev Mol Cell Biol


Koseska A, Bastiaens PIH (2020). Processing Temporal Growth Factor Patterns by an Epidermal Growth Factor Receptor Network Dynamically Established in Space Annu Rev Cell Dev Biol
doi: 10.1146/annurev-cellbio-013020-103810


Garivet G, Hofer W, Konitsiotis A, Klein C, Kaiser N, Mejuch T, Fansa E, Alsaabi R, Wittinghofer A, Bastiaens PIH, Waldmann H. (2019). Small-Molecule Inhibition of the UNC-Src Interaction Impairs Dynamic Src Localization in Cells. Cell Chem Biol
doi: 10.1016/j.chembiol.2019.02.019.


Baumdick M, Gelléri M, Uttamapinant C, Beránek V, Chin JW, Bastiaens PIH (2018). A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation. Nat Commun
doi: 10.1038/s41467-018-06299-7.

Klein CH, Truxius DC, Vogel HA, Harizanova J, Murarka S, Martín-Gago P, Bastiaens PIH (2018). PDEδ inhibition impedes the proliferation and survival of human colorectal cancer cell lines harboring oncogenic KRas. Int J Cancer
doi: 10.1002/ijc.31859.

Stanoev A, Mhamane A, Schuermann KC, Grecco HE, Stallaert W, Baumdick M, Brüggemann Y, Joshi MS, Roda-Navarro P, Fengler S, Stockert R, Roßmannek L, Luig J, Koseska A, Bastiaens PIH (2018). Interdependence between EGFR and Phosphatases Spatially Established by Vesicular Dynamics Generates a Growth Factor Sensing and Responding Network. Cell Syst
doi: 10.1016/j.cels.2018.06.006.

Corbat AA, Schuermann KC, Liguzinski P, Radon Y, Bastiaens PIH, Verveer PJ, Grecco HE (2018). Co-imaging extrinsic, intrinsic and effector caspase activity by fluorescence anisotropy microscopy. Redox Biol
doi: 10.1016/j.redox.2018.07.023.

Stallaert W, Brüggemann Y, Sabet O, Baak L, Gattiglio M, Bastiaens PIH (2018). Contact inhibitory Eph signaling suppresses EGF-promoted cell migration by decoupling EGFR activity from vesicular recycling. Sci Sig
doi: 10.1126/scisignal.aat0114.

Schwille P, Spatz J, Landfester K, Bodenschatz E, Herminghaus S, Sourjik V, Erb T, Bastiaens P, Lipowsky R, Hyman A, Dabrock P, Baret JC, Vidakovic-Koch T, Bieling P, Dimova R, Mutschler H, Robinson T, Tang D, Wegner S, Sundmacher K (2018). MaxSynBio - Avenues towards creating cells from the bottom up. Angew Chem Int Engl
doi: 10.1002/anie.201802288.

Koos B, Christmann J, Plettenberg S, Käding D, Becker J, Keteku M, Klein C, Imtiaz S, Janning P, Bastiaens PIH, Wehner F. (2018). Hypertonicity-induced cation channels (HICCs) in HepG2 cells: architecture and role in proliferation vs. apoptosis. J Physiol
doi: 10.1113/JP275827


Tsutsumi R, Harizanova J, Stockert R, Schröder K, Bastiaens PIH, Neel BG. (2017). Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2. Nat Commun 8(1):466
doi: 10.1038/s41467-017-00503-w.

Antonios D. Konitsiotis, Lisaweta Roßmannek, Angel Stanoev, Malte Schmick & Philippe I.H. Bastiaens (2017). Spatial cycles mediated by UNC119 solubilisation maintain Src family kinases plasma membrane localisation. Nat Commun 8:114
doi: 10.1038/s41467-017-00116-3.

Huebinger J, Masip ME, Christmann J, Wehner F, Bastiaens PIH. (2017). Reversible Cryo-arrests of Living Cells to Pause Molecular Movements for High-resolution Imaging. Bio Protoc
doi: 10.21769/BioProtoc.2236.

Koseska A, Bastiaens PI (2017). Cell signaling as a cognitive process. EMBO J
doi: 10.15252/embj.201695383.

Martín-Gago P, Fansa EK, Klein CH, Murarka S, Janning P, Schürmann M, Metz M, Ismail S, Schultz-Fademrecht C, Baumann M, Bastiaens PI, Wittinghofer A, Waldmann H (2017). A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2. Angew Chem Int Ed Engl
doi: 10.1002/anie.201610957.


Masip ME, Huebinger J, Christmann J, Sabet O, Wehner F, Konitsiotis A, Fuhr GR, Bastiaens PI (2016). Reversible cryo-arrest for imaging molecules in living cells at high spatial resolution. Nat Methods. 13(8):665-72.
doi: 10.1038/nmeth.3921

Papke B, Murarka S, Vogel HA, Martín-Gago P, Kovacevic M, Truxius DC, Fansa EK, Ismail S, Zimmermann G, Heinelt K, Schultz-Fademrecht C, Al Saabi A, Baumann M, Nussbaumer P, Wittinghofer A, Waldmann H, Bastiaens PI (2016). Identification of pyrazolopyridazinones as PDEδ inhibitors. Nat Commun 7:11360. doi: 10.1038/ncomms11360.
doi: 10.1038/ncomms11360.

Christmann J, Azer L, Dörr D, Fuhr GR, Bastiaens PI, Wehner F (2016). Adaptive responses of cell hydration to a low temperature arrest. J Physiol 594(6):1663-76.
doi: doi: 10.1113/JP271245.


Baumdick M, Brüggemann Y, Schmick M, Xouri G, Sabet O, Davis L, Chin JW, Bastiaens PI (2015). EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling.ELife 4: e12223.
doi: 10.7554/eLife.12223.

Ibach J, Radon Y, Gelleri M, Sonntag MH, Brunsveld L, Bastiaens PI, Verveer PJ (2015). Single Particle Tracking Reveals that EGFR Signaling Activity Is Amplified in Clathrin-Coated Pits.PLoS One 10(11):e0143162.
doi: 10.1371/journal.pone.0143162.

Huebinger J, Han HM, Hofnagel O, Vetter IR, Bastiaens PI, Grabenbauer M (2016). Direct Measurement of Water States in Cryopreserved Cells Reveals Tolerance toward Ice Crystallization. Biophys J110(4):840-9.
doi: 10.1016/j.bpj.2015.09.029.

Sabet O, Stockert R, Xouri G, Brüggemann Y, Stanoev A, Bastiaens PI (2015).Ubiquitination switches EphA2 vesicular traffic from a continuous safeguard to a finite signaling mode.Nat Commun 6:8047.
doi: 10.1038/ncomms9047.

Nakhaei-Rad S, Nakhaeizadeh H, Kordes C, Cirstea IC, Schmick M, Dvorsky R, Bastiaens PI, Häussinger D, Ahmadian MR (2015). The Function of Embryonic Stem Cell-expressed RAS (E-RAS), a Unique RAS Family Member, Correlates with Its Additional Motifs and Its Structural Properties. J Biol Chem 290(25):15892-903.
doi: 10.1074/jbc.M115.640607

Bastiaens P, Birtwistle MR, Blüthgen N, Bruggeman FJ, Cho KH, Cosentino C, de la Fuente A, Hoek JB, Kiyatkin A, Klamt S, Kolch W, Legewie S, Mendes P, Naka T, Santra T, Sontag E, Westerhoff HV, Kholodenko BN (2015). Silence on the relevant literature and errors in implementation. Nat Biotechnol 33(4):336-9.
doi: 10.1038/nbt.3185.

Schmick M, Kraemer A, Bastiaens PI (2015). Ras moves to stay in place. Trends Cell Biol 25(4):190-7.
doi: 10.1016/j.tcb.2015.02.004.

Berg V, Rusch M, Vartak N, Jüngst C, Schauss A, Waldmann H, Hedberg C, Pallasch CP, Bastiaens PI, Hallek M, Wendtner CM, Frenzel LP (2015). miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL. Blood 125(19):2948-57.


Arrabito G, Schroeder H, Schröder K, Filips C, Marggraf U, Dopp C, Venkatachalapathy M, Dehmelt L, Bastiaens PI, Neyer A, Niemeyer CM (2014). Configurable low-cost plotter device for fabrication of multi-color sub-cellular scale microarrays. Small 10(14):2870-6.
doi: 10.1002/smll.201303390.

Schmick M, Vartak N, Papke B, Kovacevic M, Truxius DC, Rossmannek L, Bastiaens PI (2014). KRas localizes to the plasma membrane by spatial cycles of solubilization, trapping and vesicular transport. Cell 157(2):459-71.
doi: 10.1016/j.cell.2014.02.051.

Schmick M, Bastiaens PI (2014). The interdependence of membrane shape and cellular signal processing. Cell 156(6):1132-8.
doi: 10.1016/j.cell.2014.02.007.

Schaupp A, Sabet O, Dudanova I, Ponserre M, Bastiaens P, Klein R (2014). The composition of EphB2 clusters determines the strength in the cellular repulsion response. J Cell Biol 204(3):409-22.
doi: 10.1083/jcb.201305037.

Vartak N, Papke B, Grecco HE, Rossmannek L, Waldmann H, Hedberg C, Bastiaens PI (2014). The autodepalmitoylating activity of APT maintains the spatial organization of palmitoylated membrane proteins. Biophys J 106(1):93-105.
doi: 10.1016/j.bpj.2013.11.024.

Roda-Navarro P, Bastiaens PI (2014). Dynamic recruitment of protein tyrosine phosphatase PTPD1 to EGF stimulation sites potentiates EGFR activation. PLoS One 9(7):e103203.
doi: 10.1371/journal.pone.0103203.


Arrabito G, Reisewitz S, Dehmelt L, Bastiaens PI, Pignataro B, Schroeder H, Niemeyer CM (2013). Biochips for cell biology by combined dip-pen nanolithography and DNA-directed protein immobilization. Small 9(24):4243-9.

Symeonidou IE, Kotsantis P, Roukos V, Rapsomaniki MA, Grecco HE, Bastiaens P, Taraviras S, Lygerou Z (2013). Multi-step loading of human minichromosome maintenance proteins in live human cells. J Biol Chem 288(50):35852-67.
doi: 10.1074/jbc.M113.474825.

Zimmermann G, Papke B, Ismail S, Vartak N, Chandra A, Hoffmann M, Hahn SA, Triola G, Wittinghofer A, Bastiaens PI, Waldmann H (2013). Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature 497(7451):638-42.
doi: 10.1038/nature12205.

Gandor S, Reisewitz S, Venkatachalapathy M, Arrabito G, Reibner M, Schröder H, Ruf K, Niemeyer CM, Bastiaens PI, Dehmelt L (2013). A Protein-Interaction Array Inside a Living Cell. Angew Chem Int Ed Engl 52(18):4790-4.
doi: 10.1002/anie.201209127.

Bierbaum M, Bastiaens PI (2013). Cell cycle-dependent binding modes of the ran exchange factor RCC1 to chromatin. Biophys J 104(8):1642-51.
doi: 10.1016/j.bpj.2013.03.024.

Grecco HE, Bastiaens PI (2013). Quantifying cellular dynamics by fluorescence resonance energy transfer (FRET) microscopy. Curr Protoc Neurosci Chapter 5:Unit5.22.
doi: 10.1002/0471142301.ns0522s63.

Blümer J, Rey J, Dehmelt L, Mazel T, Wu YW, Bastiaens P, Goody RS, Itzen A (2013). RabGEFs are a major determinant for specific Rab membrane targeting. J Cell Biol 200(3):287-300.
doi: 10.1083/jcb.201209113.


van Wijk SJ, Fiskin E, Putyrski M, Pampaloni F, Hou J, Wild P, Kensche T, Grecco HE, Bastiaens P, Dikic I (2012). Fluorescence-based sensors to monitor localization and functions of linear and K63-linked ubiquitin chains in cells. Mol Cell 47(5):797-809.
doi: 10.1016/j.molcel.2012.06.017.

Fengler S, Bastiaens PI, Grecco HE, Roda-Navarro P (2012). Optimizing cell arrays for accurate functional genomics. BMC Res Notes 5(1):358.
doi: 10.1186/1756-0500-5-358.

Milroy LG, Rizzo S, Calderon A, Ellinger B, Erdmann S, Mondry J, Verveer P, Bastiaens P, Waldmann H, Dehmelt L, Arndt HD (2012). Selective chemical imaging of static actin in live cells. J Am Chem Soc 134(20):8480-6.
doi: 10.1021/ja211708z.

Görmer K, Bürger M, Kruijtzer JA, Vetter I, Vartak N, Brunsveld L, Bastiaens PI, Liskamp RM, Triola G, Waldmann H (2012). Chemical-biological exploration of the limits of the Ras de- and repalmitoylating machinery. Chembiochem13(7):1017-23.
doi: 10.1002/cbic.201200078.

Haj FG, Sabet O, Kinkhabwala A, Wimmer-Kleikamp S, Roukos V, Han HM, Grabenbauer M, Bierbaum M, Antony C, Neel BG, Bastiaens PI (2012). Regulation of signaling at regions of cell-cell contact by endoplasmic reticulum-bound protein-tyrosine phosphatase 1B. PLoS One 7(5):e36633.
doi: 10.1371/journal.pone.0036633.


Chandra A, Grecco HE, Pisupati V, Perera D, Cassidy L, Skoulidis F, Ismail SA, Hedberg C, Hanzal-Bayer M, Venkitaraman AR, Wittinghofer A, Bastiaens PI (2011). The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins. Nat Cell Biol 14(2):148-58. Erratum in: Nat Cell Biol. 2012 Mar;14(3):329.
doi: 10.1038/ncb2394.

Janes PW, Griesshaber B, Atapattu L, Nievergall E, Hii LL, Mensinga A, Chheang C, Day BW, Boyd AW, Bastiaens PI, Jørgensen C, Pawson T, Lackmann M (2011). Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors. J Cell Biol 195(6):1033-45.
doi: 10.1083/jcb.201104037.

Ismail SA, Chen YX, Rusinova A, Chandra A, Bierbaum M, Gremer L, Triola G, Waldmann H, Bastiaens PI, Wittinghofer A (2011). Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. Nat Chem Biol 7(12):942-9.
doi: 10.1038/nchembio.686.

Hedberg C, Dekker FJ, Rusch M, Renner S, Wetzel S, Vartak N, Gerding-Reimers C, Bon RS, Bastiaens PI, Waldmann H (2011). Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design. Angew Chem Int Ed Engl 50(42):9832-7.
doi: 10.1002/anie.201102965.

Grecco HE, Schmick M, Bastiaens PI (2011). Signaling from the living plasma membrane. Cell 144(6):897-909.
doi: 10.1016/j.cell.2011.01.029.

Roukos V, Kinkhabwala A, Colombelli J, Kotsantis P, Taraviras S, Nishitani H, Stelzer E, Bastiaens P, Lygerou Z (2011). Dynamic recruitment of licensing factor Cdt1 to sites of DNA damage. J Cell Sci 124(Pt 3):422-34.
doi: 10.1242/jcs.074229.

Grecco HE, Roda-Navarro P, Fengler S, Bastiaens PI (2011). High-throughput quantification of posttranslational modifications in situ by CA-FLIM. Methods Enzymol 500:37-58.
doi: 10.1016/B978-0-12-385118-5.00003-7.

vor 2011

List of Publications (12/16)

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