Publikationen von Shehab Ismail

Martín-Gago, P.; Fansa, E. K.; Klein, C.; Murarka, S.; Janning, P.; Schürmann, M.; Metz, M.; Ismail, S.; Schultz-Fademrecht, C.; Baumann, M. et al.; Bastiaens, P. I. H.; Wittinghofer, A.; Waldmann, H.: A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2. Angewandte Chemie International Edition 56 (9), S. 2423 - 2428 (2017)

Martín-Gago, P.; Fansa, E. K.; Klein, C.; Murarka, S.; Janning, P.; Schürmann, M.; Metz, M.; Ismail, S.; Schultz-Fademrecht, C.; Baumann, M. et al.; Bastiaens, P. I. H.; Wittinghofer, A.; Waldmann, H.: A PDE6d-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2. Angewandte Chemie 129 (9), S. 2463 - 2468 (2017)

Papke, B.; Murarka, S.; Vogel, H. A.; Martín-Gago, P.; Kovacevic, M.; Truxius, D.; Fansa, E. K.; Ismail, S.; Zimmermann, G.; Heinelt, K. et al.; Schultz-Fademrecht, C.; Al Saabi, A.; Baumann, M.; Nussbaumer, P.; Wittinghofer, A.; Waldmann, H.; Bastiaens, P. I. H.: Identification of pyrazolopyridazinones as PDEδ inhibitors. Nature Communications 7, 11360, S. 1 - 9 (2016)

Kapoor, S.; Fansa, E. K.; Möbitz, S.; Ismail, S.; Winter, R.; Wittinghofer, A.; Weise, K.: Effect of the N-Terminal Helix and Nucleotide Loading on the Membrane and Effector Binding of Arl2/3. Biophysical Journal 109 (8), S. 1619 - 1629 (2015)

Zimmermann, G.; Schultz-Fademrecht, C.; Küchler, P.; Murarka, S.; Ismail, S.; Triola, G.; Nussbaumer, P.; Wittinghofer, A.; Waldmann, H.: Structure Guided Design and Kinetic Analysis of Highly Potent Benzimidazole Inhibitors Targeting the PDEδ Prenyl Binding Site. Journal of Medicinal Chemistry 57 (12), S. 5435 - 5448 (2014)

Bravo-Rodriguez, K.; Ismail-Ali, A. F.; Klopries, S.; Kushnir, S.; Ismail, S.; Fansa, E. K.; Wittinghofer, A.; Schulz, F.; Sanchez-Garcia, E.: Predicted incorporation of non-native substrates by a polyketide synthase yields bioactive natural product derivatives. ChemBioChem: A European Journal of Chemical Biology 15 (13), S. 1991 - 1997 (2014)

Zimmermann, G.; Papke, B.; Ismail, S.; Vartak, N.; Chandra, A.; Hoffmann, M.; Hahn, S. A.; Triola, G.; Wittinghofer, A.; Bastiaens, P. I. H. et al.; Waldmann, H.: Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature 497 (7451), 1, S. 638 - 642 (2013)

Wätzlich, D.; Vetter, I. R.; Gotthardt, K.; Miertzschke, M.; Chen, Y.-X.; Wittinghofer, A.; Ismail, S.: The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo. EMBO Reports 14 (5), 1, S. 465 - 472 (2013)