Publikationen von Lydia Borgelt

Borgelt, L.; Hohnen, L.; Hommen, P.; Goebel , G. L.; Liu, Y.; O'Mahony, G.; Wu, P.: N-Biphenyl Pyrrolinones and Dibenzofurans as RNA-Binding Protein LIN28 Inhibitors Disrupting the LIN28–Let-7 Interaction. ACS Medicinal Chemistry Letters (2023)

Borgelt, L.; Haacke, N.; Lampe, P.; Qiu, X.; Gasper, R.; Schiller, D.; Sievers, S.; Wu, P.: Small-molecule screening of ribonuclease L binders for RNA degradation. Biomedicine & Pharmacotherapy 154 (2023)

Borgelt, L.; Wu, P.: Targeting Ribonucleases with Small Molecules and Bifunctional Molecules. ACS Chemical Biology 18 (10), S. 2101 - 2113 (2023)

Hwang, J.; Haacke, N.; Borgelt, L.; Qiu, X.; Gasper, R.; Wu, P.: Rational design and evaluation of 2-((pyrrol-2-yl)methylene)thiophen-4-ones as RNase L inhibitors. European Journal of Medicinal Chemistry (2023)

Borgelt, L.; Huang, F.; Hohnen, L.; Qiu, X.; Goebel, G. L.; Hommen, P.; Wu, P.: Spirocyclic Chromenopyrazole Inhibitors Disrupting the Interaction between the RNA-Binding Protein LIN28 and Let-7. ChemBioChem: A European Journal of Chemical Biology (2023)

Hwang, J.; Qiu, X.; Borgelt, L.; Haacke, N.; Kanis, L.; Petroulia, S.; Gasper, R.; Schiller, D.; Lampe, P.; Sievers, S. et al.; Imig, J.; Wu, P.: Synthesis and evaluation of RNase L-binding 2-aminothiophenes as anticancer agents. Bioorganic & Medicinal Chemistry 58, 116653, S. 1 - 15 (2022)

Goebel, G. L.; Hohnen, L.; Borgelt, L.; Hommen, P.; Qiu, X.; Lightfoot , H.; Wu, P.: Small molecules with tetrahydroquinoline-containing Povarov scaffolds as inhibitors disrupting the ProteineRNA interaction of LIN28elet-7. European Journal of Medicinal Chemistry 228, 114014, S. 1 - 14 (2021)

Borgelt, L.; Li, F.; Hommen, P.; Lampe, P.; Hwang, J.; Goebel, G. L.; Sievers, S.; Wu, P.: Trisubstituted Pyrrolinones as Small-Molecule Inhibitors Disrupting the Protein-RNA Interaction of LIN28 and Let-7. ACS Medicinal Chemistry Letters 12 (6), S. 893 - 898 (2021)

Hwang, J.; Borgelt, L.; Wu, P.: Multicomponent Petasis Reaction for the Synthesis of Functionalized 2-Aminothiophenes and Thienodiazepines. ACS Combinatorial Science 22 (10), S. 495 - 499 (2020)

Borgelt, L.: Discovery of small-molecule modulators of the RNA-binding proteins LIN28 and RNase L. Dissertation, TU Dortmund, Dortmund (2023)

Borgelt, L.: Structural Studies of the Pex1p Pex6p Complex by Transmission Electron Microscopy. Master, Technische Universität Dortmund, Dortmund (2018)