Charles Loh

Forschungsgruppenleiter, Chemische Biologie

Bioaktivität im Fokus kreativer organischer Synthese

Publikationen

2022

Rao VUB, Wang C, Demarque DP, Grassin C, Otte F, Merten C, Strohmann C, Loh CCJ (2022). A synergistic Rh(I)/organoboron-catalysed site-selective carbohydrate functionalization that involves multiple stereocontrol. Quelle

2021

Loh CCJ (2021). Exploiting non-covalent interactions in selective carbohydrate synthesis. Nature Reviews Chemistry Quelle

2020

Xu C, Bhaskara Rao VU, Weigen J, Loh CCJ (2020). A robust and tunable halogen bond organocatalyzed 2-deoxyglycosylation involving quantum tunneling. Nat Commun Quelle

2019

Xu C, Loh CCJ (2019). A Multistage Halogen Bond Catalyzed Strain-Release Glycosylation Unravels New Hedgehog Signaling Inhibitors. J Am Chem Soc 141(13):5381-5391. doi: 10.1021/jacs.9b00040.

2018

Xu C, Loh CCJ (2018). An ultra-low thiourea catalyzed strain-release glycosylation and a multicatalytic diversification strategy. Nat Commun 9(1):4057. doi: 10.1038/s41467-018-06329-4.

2017

Yen A, Choo KL, Yazdi SK, Franke PT, Webster R, Franzoni I, Loh CCJ, Poblador-Bahamonde AI, Lautens M (2017). Rhodium-Catalyzed Enantioselective Isomerization of meso-Oxabenzonorbornadienes to 1,2-Naphthalene Oxides. Angew Chem Int Ed 56(22):6307-6311. doi: 10.1002/anie.201403712

2016

Loh CC, Schmid M, Webster R, Yen A, Yazdi SK, Franke PT, Lautens M. (2016). Rhodium-Catalyzed Asymmetric Cycloisomerization and Parallel Kinetic Resolution of Racemic Oxabicycles. Angew Chem Int Ed 55(34):10074-8. doi: 10.1002/anie.201604937.

Loh CC, Schmid M, Peters B, Fang X, Lautens M (2016). Exploiting Distal Reactivity of Coumarins: A Rhodium-Catalyzed Vinylogous Asymmetric Ring-Opening Reaction. Angew Chem Int Ed 55(14):4600-4. doi: 10.1002/anie.201600654.

2015

Loh CC, Schmid M, Fang X, Lautens M (2015). Benzylic Functionalization of Anthrones via the Asymmetric Ring Opening of Oxabicycles Utilizing a Fourth-Generation Rhodium Catalytic System. Chemistry 21(40):13883-7. doi: 10.1002/chem.201502718

Mahajan S, Chauhan P, Loh CC, Uzungelis S, Raabe G, Enders D (2015). Organocatalytic Asymmetric Domino Michael/Henry Reaction of Indolin-3-ones with o-Formyl-β-nitrostyrenes. Synthesis 1;47(7):1024-1031. doi: 10.1002/chem.201502718

2014

Chauhan P, Mahajan S, Loh CC, Raabe G, Enders D (2014). Streocontrolled construction of six vicinal stereogenic centers on spiropyrazolones via organocascade Michael/Michael/1,2-addition reactions. Org Letter 16(11):2954-7. doi: 10.1021/ol501093v.

Hack D, Loh CC, Hartmann JM, Raabe G, Enders D (2014). Merging gold and organocatalysis: a facile asymmetric synthesis of annulated pyrroles. Chemistry 20(14):3917-21. doi: 10.1002/chem.201400407.

2013

Loh CC, Atodiresei I, Enders D (2013). Asymmetric organocatalytic Michael/Henry domino reactions through hydrogen-bond activation: kinetic access to indane scaffolds bearing cis-vicinal substituents. Chemistry 19(33):10822-6. doi: 10.1002/chem.201302131

Loh CC, Hack D, Enders D. (2013). Asymmetric domino synthesis of indanes bearing four contiguous stereocentres catalyzed by sub-mol% loadings of a squaramide in minutes. Chem Commun (Camb) 49(87):10230-2. doi: 10.1039/c3cc46033a.

HNi Q, Zhang H, Grossmann A, Loh CC, Merkens C, Enders D (2013). Asymmetric synthesis of pyrroloindolones by N-heterocyclic carbene catalyzed [2+3] annulation of α-chloroaldehydes with nitrovinylindoles. Angew Chem Int Ed Engl. 52(51):13562-6. doi: 10.1002/anie.201305957.

2012

Loh CC, Enders D (2012). Exploiting the electrophilic properties of indole intermediates: new options in designing asymmetric reactions. Angew Chem Int Ed Engl 51(1):46-8.. doi: 10.1002/anie.201107575.

Loh CC, Enders D (2012). Merging organocatalysis and gold catalysis--a critical evaluation of the underlying concepts. .Chemistry< 18(33):10212-25 doi: 10.1002/chem.201200287.

Wang C, Yang X, Loh CC, Raabe G, Enders D (2012). Organocatalytic, asymmetric synthesis of 3-sulfenylated N-Boc-protected oxindoles. Chemistry 18(37):11531-5. doi: 10.1002/chem.201201262.

Wan JP, Loh CC, Pan F, Enders D (2012). Enantioselective organocatalytic domino synthesis of tetrahydropyridin-2-ols. Chem Commun (Camb) 48(80):10049-51. doi: 10.1039/c2cc35644a.

Loh CC, Raabe G, Enders D (2012). Enantioselective synthesis of tetrahydrocarbazoles through a Michael addition/Ciamician-Plancher rearrangement sequence: asymmetric synthesis of a potent constrained analogue of MS-245. Chemistry 18(42):13250-4. doi: 10.1002/chem.201202908.