Charles Loh

Research Group Leader, Chemical Biology

Dazzling Synthesis with Creativity, Targeting Bioactivity with Flair

Publications

2022

Rao VUB, Wang C, Demarque DP, Grassin C, Otte F, Merten C, Strohmann C, Loh CCJ (2022). A synergistic Rh(I)/organoboron-catalysed site-selective carbohydrate functionalization that involves multiple stereocontrol. Source

2021

Loh CCJ (2021). Exploiting non-covalent interactions in selective carbohydrate synthesis. Nature Reviews Chemistry Source

2020

Xu C, Bhaskara Rao VU, Weigen J, Loh CCJ (2020). A robust and tunable halogen bond organocatalyzed 2-deoxyglycosylation involving quantum tunneling. Nat Commun Source

2019

Xu C, Loh CCJ (2019). A Multistage Halogen Bond Catalyzed Strain-Release Glycosylation Unravels New Hedgehog Signaling Inhibitors. J Am Chem Soc 141(13):5381-5391. Source

2018

Xu C, Loh CCJ (2018). An ultra-low thiourea catalyzed strain-release glycosylation and a multicatalytic diversification strategy. Nat Commun 9(1):4057. doi: 10.1038/s41467-018-06329-4.

2017

Yen A, Choo KL, Yazdi SK, Franke PT, Webster R, Franzoni I, Loh CCJ, Poblador-Bahamonde AI, Lautens M (2017). Rhodium-Catalyzed Enantioselective Isomerization of meso-Oxabenzonorbornadienes to 1,2-Naphthalene Oxides. Angew Chem Int Ed 56(22):6307-6311. doi: 10.1002/anie.201403712

2016

Loh CC, Schmid M, Webster R, Yen A, Yazdi SK, Franke PT, Lautens M. (2016). Rhodium-Catalyzed Asymmetric Cycloisomerization and Parallel Kinetic Resolution of Racemic Oxabicycles. Angew Chem Int Ed 55(34):10074-8. doi: 10.1002/anie.201604937.

Loh CC, Schmid M, Peters B, Fang X, Lautens M (2016). Exploiting Distal Reactivity of Coumarins: A Rhodium-Catalyzed Vinylogous Asymmetric Ring-Opening Reaction. Angew Chem Int Ed 55(14):4600-4. doi: 10.1002/anie.201600654.

2015

Loh CC, Schmid M, Fang X, Lautens M (2015). Benzylic Functionalization of Anthrones via the Asymmetric Ring Opening of Oxabicycles Utilizing a Fourth-Generation Rhodium Catalytic System. Chemistry 21(40):13883-7. doi: 10.1002/chem.201502718

Mahajan S, Chauhan P, Loh CC, Uzungelis S, Raabe G, Enders D (2015). Organocatalytic Asymmetric Domino Michael/Henry Reaction of Indolin-3-ones with o-Formyl-β-nitrostyrenes. Synthesis 1;47(7):1024-1031. doi: 10.1002/chem.201502718

2014

Chauhan P, Mahajan S, Loh CC, Raabe G, Enders D (2014). Streocontrolled construction of six vicinal stereogenic centers on spiropyrazolones via organocascade Michael/Michael/1,2-addition reactions. Org Letter 16(11):2954-7. doi: 10.1021/ol501093v.

Hack D, Loh CC, Hartmann JM, Raabe G, Enders D (2014). Merging gold and organocatalysis: a facile asymmetric synthesis of annulated pyrroles. Chemistry 20(14):3917-21. doi: 10.1002/chem.201400407.

2013

Loh CC, Atodiresei I, Enders D (2013). Asymmetric organocatalytic Michael/Henry domino reactions through hydrogen-bond activation: kinetic access to indane scaffolds bearing cis-vicinal substituents. Chemistry 19(33):10822-6. doi: 10.1002/chem.201302131

Loh CC, Hack D, Enders D. (2013). Asymmetric domino synthesis of indanes bearing four contiguous stereocentres catalyzed by sub-mol% loadings of a squaramide in minutes. Chem Commun (Camb) 49(87):10230-2. doi: 10.1039/c3cc46033a.

HNi Q, Zhang H, Grossmann A, Loh CC, Merkens C, Enders D (2013). Asymmetric synthesis of pyrroloindolones by N-heterocyclic carbene catalyzed [2+3] annulation of α-chloroaldehydes with nitrovinylindoles. Angew Chem Int Ed Engl. 52(51):13562-6. doi: 10.1002/anie.201305957.

2012

Loh CC, Enders D (2012). Exploiting the electrophilic properties of indole intermediates: new options in designing asymmetric reactions. Angew Chem Int Ed Engl 51(1):46-8.. doi: 10.1002/anie.201107575.

Loh CC, Enders D (2012). Merging organocatalysis and gold catalysis--a critical evaluation of the underlying concepts. .Chemistry< 18(33):10212-25 doi: 10.1002/chem.201200287.

Wang C, Yang X, Loh CC, Raabe G, Enders D (2012). Organocatalytic, asymmetric synthesis of 3-sulfenylated N-Boc-protected oxindoles. Chemistry 18(37):11531-5. doi: 10.1002/chem.201201262.

Wan JP, Loh CC, Pan F, Enders D (2012). Enantioselective organocatalytic domino synthesis of tetrahydropyridin-2-ols. Chem Commun (Camb) 48(80):10049-51. doi: 10.1039/c2cc35644a.

Loh CC, Raabe G, Enders D (2012). Enantioselective synthesis of tetrahydrocarbazoles through a Michael addition/Ciamician-Plancher rearrangement sequence: asymmetric synthesis of a potent constrained analogue of MS-245. Chemistry 18(42):13250-4. doi: 10.1002/chem.201202908.