Andrea Musacchio
Direktor, Mechanistische Zellbiologie
Publikationen
PubMed Liste>
> Publikationsliste 01/2023 als PDF
2024
Hedtfeld M, Dammers A, Koerner C, Musacchio A (2024). A validation strategy to assess the role of phase separation as a determinant of macromolecular localization. Mol Cell
Source
Polley S, Raisch T, Ghetti S, Körner M, Terbeck M, Gräter F, Raunser S, Aponte-Santamaria Camilo, Vetter IR, Musacchio A (2024). Structure of the human KMN complex and implications for regulation of its assembly. NSMB
Source
2023
Cmentowski V, Ciossani G, d'Amico E, Wohlgemuth S, Owa M, Dynlacht B, Musacchio A (2023). RZZ-Spindly and CENP-E form an integrated platform to recruit dynein to the kinetochore corona. EMBO J.
Source
Polley S, Müschenborn H, Terbeck M, De Antoni A, Vetter IR, Dogterom M, Musacchio A, Volkov VA, Huis In 't Veld PJ (2023). Stable kinetochore-microtubule attachment requires loop-dependent Ndc80-Ndc80 binding. EMBO J.
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Chen C, Piano V, Alex A, Han SJY, Huis In 't Veld PJ, Roy B, Fergle D, Musacchio A, Joglekar AP (2023). The structural flexibility of MAD1 facilitates the assembly of the Mitotic Checkpoint Complex. Nat Commun.
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Di Cesare E, Moroni S, Bartoli J, Damizia M, Giubettini M, Koerner C, Krenn V, Musacchio A, Lavia P (2023). Aurora B SUMOylation Is Restricted to Centromeres in Early Mitosis and Requires RANBP2. Cells
Source
2022
Schwietert F, Volkov VA, Huis In 't Veld PJ, Dogterom M, Musacchio A, Kierfeld J (2022). Strain stiffening of Ndc80 complexes attached to microtubule plus ends. Biophys. J.
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d'Amico EA, Ud Din Ahmad M, Cmentowski V, Girbig M, Müller F, Wohlgemuth S, Brockmeyer A, Maffini S, Janning P, Vetter IR, Carter AP, Perrakis A, Musacchio A (2022). Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin. J Cell Biol.
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Celestino R, Gama JB, Castro-Rodrigues AF, Barbosa DJ, Rocha H, d'Amico EA, Musacchio A, Carvalho AX, Morais-Cabral JH, Gassmann R (2022). JIP3 interacts with dynein and kinesin-1 to regulate bidirectional organelle transport. J Cell Biol.
Source
Pesenti ME, Raisch T, Conti D, Walstein K, Hoffmann I, Vogt D, Prumbaum D, Vetter IR, Raunser S, Musacchio A (2022). Structure of the human inner kinetochore CCAN complex and its significance for human centromere organization. Mol Cell
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Raisch T, Ciossani G, d'Amico E, Cmentowski V, Carmignani S, Maffini S, Merino F, Wohlgemuth S, Vetter IR, Raunser S, Musacchio A (2022). Structure of the RZZ complex and molecular basis of Spindly-driven corona assembly at human kinetochores. EMBO J
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Musacchio A (2022). On the role of phase separation in the biogenesis of membraneless compartments. EMBO J.
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Martin IM, Aponte-Santamaría C, Schmidt L, Hedtfeld M, Iusupov A, Musacchio A, Gräter F (2022). Phosphorylation tunes elongation propensity and cohesiveness of INCENP's intrinsically disordered region. J Mol Biol.
Source
2021
van den Boom J, Kueck AF, Kravic B, Müschenborn H, Giesing M, Pan D, Kaschani F, Kaiser M, Musacchio A, Meyer H (2021). Targeted substrate loop insertion by VCP/p97 during PP1 complex disassembly. Nat Struct Mol Biol
Source
Huis In 't Veld PJ, Wohlgemuth S, Koerner C, Müller F, Janning P, Musacchio A (2021).Reconstitution and use of highly active human CDK1:Cyclin-B:CKS1 complexes. Protein Sci
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Walstein K, Petrovic A, Pan D, Hagemeier B, Vogt D, Vetter I & Musacchio A (2021).Assembly principles and stoichiometry of a complete human kinetochore module. Science Advances
Source
Piano V, Alex A, Stege P, Maffini S, Stoppiello GA, Huis In 't Veld PJ, Vetter IR, Musacchio A (2021). CDC20 assists its catalytic incorporation in the mitotic checkpoint complex. Science
Source
2020
Singh P, Pesenti ME, Maffini S, Carmignani S, Hedtfeld M, Petrovic A, Srinivasamani A, Bange T, Musacchio 2020). BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis. Mol Cell
Quelle
Kong M, Cutts EE, Pan D, Beuron F, Kaliyappan T, Xue C, Morris EP, Musacchio A, Vannini A, Greene EC. (2020). Human Condensin I and II Drive Extensive ATP-Dependent Compaction of Nucleosome-Bound DNA. Mol Cell
doi: 10.1016/j.molcel.2020.04.026.
Allan LA, Camacho Reis M, Ciossani G, Huis In 't Veld PJ, Wohlgemuth S, Kops GJ, Musacchio A, Saurin AT (2020). Cyclin B1 scaffolds MAD1 at the kinetochore corona to activate the mitotic checkpoint. EMBO J.
doi: 10.15252/embj.2019103180.
2019
Huis In 't Veld PJ, Volkov VA, Stender ID, Musacchio A, Dogterom M (2019). Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling. Elife
doi: 10.7554/eLife.49539
Pan D, Walstein K, Take A, Bier D, Kaiser N, Musacchio A (2019). Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing. Nature Communications
doi: 10.1038/s41467-019-12019-6.
Alex A, Piano V, Polley S, Stuiver M, Voss S, Ciossani G, Overlack K, Voss B, Wohlgemuth S, Petrovic A, Wu Y, Selenko P, Musacchio A, Maffini S (2019). Electroporated recombinant proteins as tools for in vivo functional complementation, imaging, and chemical biology. ELife
doi: 10.7554/eLife.48287
2018
Weith M, Seiler J, van den Boom J, Kracht M, Hülsmann J, Primorac I, Del Pino Garcia J, Kaschani F, Kaiser M, Musacchio A, Bollen M, Meyer H (2018). Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation. Mol Cell
doi: 10.1016/j.molcel.2018.09.020.
Pesenti ME, Prumbaum D, Auckland P, Smith CM, Faesen AC, Petrovic A, Erent M, Maffini S, Pentakota S, Weir JR, Lin YC, Raunser S, McAinsh AD, Musacchio A (2018). Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80. Mol Cell
doi: 10.1016/j.molcel.2018.07.038.
Pan D, Brockmeyer A, Mueller F, Musacchio A, Bange T (2018). Simplified Protocol for Cross-linking Mass Spectrometry Using the MS-Cleavable Cross-linker DSBU with Efficient Cross-link Identification. Anal Chem
doi: 10.1021/acs.analchem.8b02593
Sacristan C, Ahmad MUD, Keller J, Fermie J, Groenewold V, Tromer E, Fish A, Melero R, Carazo JM, Klumperman J, Musacchio A, Perrakis A, Kops GJ. (2018). Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis. Nat Cell Biol
doi: 10.1038/s41556-018-0130-3.
Ciossani G, Overlack K, Petrovic A, Huis In 't Veld PJ, Koerner C, Wohlgemuth S, Maffini S, Musacchio A (2018). The kinetochore proteins CENP-E and CENP-F directly and specifically interact with distinct BUB mitotic checkpoint Ser/Thr kinases. eLife
doi: 10.1074/jbc.RA118.003154.
Volkov VA, Huis In 't Veld PJ, Dogterom M, Musacchio A. (2018). Multivalency of NDC80 in the outer kinetochore is essential to track shortening microtubules and generate forces. eLife
doi: 10.7554/eLife.36764
2017
Pentakota S, Zhou K, Smith C, Maffini S, Petrovic A, Morgan GP, Weir JR, Vetter IR, Musacchio A, Luger K (2017). Decoding the centromeric nucleosome through CENP-N. eLife
doi: 10.7554/eLife.33442.
Overlack K, Bange T, Weissmann F, Faesen AC, Maffini S, Primorac I, Müller F, Peters JM, Musacchio A (2017). BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint Signaling. Curr Biol
doi: 10.1016/j.cub.2017.08.033.
Mosalaganti S, Keller J, Altenfeld A, Winzker M, Rombaut P, Saur M, Petrovic A, Wehenkel A, Wohlgemuth S, Müller F, Maffini S, Bange T, Herzog F, Waldmann H, Raunser S & Musacchio A (2017). Structure of the RZZ complex and molecular basis of its interaction with Spindly. J Cell Bio 216(4):961-981
doi: 10.1083/jcb.201611060.
Musacchio A, Desai A (2017). A Molecular View of Kinetochore Assembly and Function Biology (Basel) 6(1). pii: E5.
doi: doi: 10.3390/biology6010005.
Faesen AC, Thanasoula M, Maffini S, Breit C, Müller F, van Gerwen S, Bange T, Musacchio A (2017). Basis of catalytic assembly of the mitotic checkpoint complex. Nature
doi: 10.1038/nature21384.
Pan D, Klare K, Petrovic A, Take A, Walstein K, Singh P, Rondelet A, Bird AW, Musacchio A (2017). CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading. eLife 6:e23352.
doi: 10.7554/eLife.23352.
2016
Huis In 't Veld PJ, Jeganathan S, Petrovic A, Singh P, John J, Krenn V, Weissmann F, Bange T, Musacchio A (2016). Molecular basis of outer kinetochore assembly on CENP-T. eLife 5:e21007.
doi: 10.7554/eLife.21007.
Petrovic A, Keller J, Liu Y, Overlack K, John J, Dimitrova YN, Jenni S, van Gerwen S, Stege P, Wohlgemuth S, Rombaut P, Herzog F, Harrison SC, Vetter IR, and Musacchio A (2016). Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores. Cell 167(4):1028-1040.e15. doi: http://dx.doi.org/10.1016/j.cell.2016.10.005
Weir JR, Faesen AC, Klare K, Petrovic A, Basilico F, Fischböck J, Pentakota S, Keller J, Pesenti ME, Pan D, Vogt D, Wohlgemuth S, Herzog F, Musacchio A (2016). Insights from biochemical reconstitution into the architecture of human kinetochores. Nature 537(7619):249-253. doi: 10.1038/nature19333.
Borisy G, Heald R, Howard J, Janke C, Musacchio A, Nogales E (2016). Microtubules: 50 years on from the discovery of tubulin. Nat Rev Mol Cell Biol. (5):322-8. doi: 10.1038/nrm.2016.45.
Friese A, Faesen AC, Huis in 't Veld PJ, Fischböck J, Prumbaum D, Petrovic A, Raunser S, Herzog F, Musacchio A (2016). Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and Astrin. Nat Commun 7:11407. doi: 10.1038/ncomms11407.
Pesenti ME, Weir JR, Musacchio A (2016). Progress in the structural and functional characterization of kinetochores. Curr Opin Struct 37:152-63. doi: 10.1016/j.sbi.2016.03.003. doi: 10.1038/nature19333.
Liu Y, Petrovic A, Rombaut P, Mosalaganti S, Keller J, Raunser S, Herzog F, Musacchio A (2016)..Insights from the reconstitution of the divergent outer kinetochore of Drosophila melanogaster. Open Biol 150236. doi: 10.1098/rsob.150236.
2015
O'Connor A, Maffini S, Rainey MD, Kaczmarczyk A, Gaboriau D, Musacchio A, Santocanale C (2015). Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint. Biol Open 5(1):11-9. doi: 10.1242/bio.014969. doi: 10.1242/bio.014969.
Musacchio A (2015). The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics. Curr Biol 25(20):R1002-18. doi: 10.1016/j.cub.2015.08.051.
Klare K, Weir JR, Basilico F, Zimniak T, Massimiliano L, Ludwigs N, Herzog F, Musacchio A (2015). CENP-C is a blueprint for constitutive centromere-associated network assembly within human kinetochores. J Cell Biol 210(1):11-22. doi: 10.1083/jcb.201412028.
Meyer R, Faesen A, Vogel K, Jeganathan S, Musacchio A, Niemeyer CM (2015). DNA-Directed Assembly of Capture Tools for Constitutional Studies of Large Protein Complexes. Small11(22):2669-74. doi: 10.1002/smll.201403544. doi: 10.1002/smll.201403544.
Musacchio A (2015). Closing the Mad2 cycle. Elife doi: 10.7554/eLife.08283.
Tachiwana H, Müller S, Blümer J, Klare K, Musacchio A, Almouzni G (2015). HJURP involvement in de novo CenH3(CENP-A) and CENP-C recruitment. Cell Rep 11(1):22-32. doi: 10.1016/j.celrep.2015.03.013.
Altenfeld A, Wohlgemuth S, Wehenkel A, Vetter IR, Musacchio A (2015). Complex assembly, crystallization and preliminary X-ray crystallographic analysis of the human Rod-Zwilch-ZW10 (RZZ) complex. Acta Crystallogr F Struct Biol Commun 71(Pt 4):438-42. doi: 10.1107/S2053230X15004343.
Faesen AC, Musacchio A (2015). The (phospho) needle in the (MELT) Haystack. Mol Cell 57(5):765-6. doi: 10.1016/j.molcel.2015.02.026.
Overlack K, Primorac I, Vleugel M, Krenn V, Maffini S, Hoffmann I, Kops GJ, Musacchio A (2015). A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint. Elife 4:e05269. doi: 10.7554/eLife.05269.
Krenn V, Musacchio A (2015). The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling. Front Oncol 5:225. doi: 10.3389/fonc.2015.00225.
Breit C, Bange T, Petrovic A, Weir JR, Müller F, Vogt D, Musacchio A (2015). Role of Intrinsic and Extrinsic Factors in the Regulation of the Mitotic Checkpoint Kinase Bub1. PLoS One 10(12):e0144673. doi: 10.1371/journal.pone.0144673.
2014
Vader G, Musacchio A (2014). HORMA domains at the heart of meiotic chromosome dynamics. Dev Cell 31(4):389-91.
doi: 10.1016/j.devcel.2014.11.009.
Eiteneuer A, Seiler J, Weith M, Beullens M, Lesage B, Krenn V, Musacchio A, Bollen M, Meyer H (2014). Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1. EMBO J33(22):2704-20. doi: 10.15252/embj.201489054.
Basilico F, Maffini S, Weir JR, Prumbaum D, Rojas AM, Zimniak T, De Antoni A, Jeganathan S, Voss B, van Gerwen S, Krenn V, Massimiliano L, Valencia A, Vetter IR, Herzog F, Raunser S, Pasqualato S & Musacchio A (2014). The pseudo GTPase CENP-M drives human kinetochore assembly. Elife 8:e02978. doi: 10.7554/eLife.02978
Overlack K, Krenn V, Musacchio A (2014). When Mad met Bub. EMBO Rep 15(4):326-8. doi: 10.1002/embr.201438574.
Petrovic A, Mosalaganti S, Keller J, Mattiuzzo M, Overlack K, Krenn V, De Antoni A, Wohlgemuth S, Cecatiello V, Pasqualato S, Raunser S, Musacchio A (2014). Modular assembly of RWD domains on the Mis12 complex underlies outer kinetochore organization. Mol Cell 53(4):591-605. doi: 10.1016/j.molcel.2014.01.019.
Krenn V, Overlack K, Primorac I, van Gerwen S, Musacchio A (2014). KI motifs of human Knl1 enhance assembly of comprehensive spindle checkpoint complexes around MELT repeats. Curr Biol24(1):29-39. doi: 10.1016/j.cub.2013.11.046.
2013
Musacchio A, Helin K (2013). Cell cycle, differentiation and disease. Curr Opin Cell Biol 25(6):673-5. doi: 10.1016/j.ceb.2013.09.003.
Primorac I, Weir JR, Chiroli E, Gross F, Hoffmann I, van Gerwen S, Ciliberto A, Musacchio A (2013). Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling. Elife 2:e01030. doi: 10.7554/eLife.01030. doi: 10.7554/eLife.01030.
Primorac I, Musacchio A (2013). Panta rhei: the APC/C at steady state. J Cell Biol201(2):177-89. doi: 10.1083/jcb.201301130.
Musacchio A, Ciliberto A (2013). The spindle-assembly checkpoint and the beauty of self-destruction. Nat Struct Mol Biol 19(11):1059-61. Erratum in: Nat Struct Mol Biol. 2013 Feb;20(2):244. doi: 10.1038/nsmb.2429.
2012
Mariani L, Chiroli E, Nezi L, Muller H, Piatti S, Musacchio A, Ciliberto A (2012). Role of the Mad2 dimerization interface in the spindle assembly checkpoint independent of kinetochores. Curr Biol 22(20):1900-8. doi: 10.1016/j.cub.2012.08.028.
De Antoni A, Maffini S, Knapp S, Musacchio A, Santaguida S (2012). A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B. J Cell Biol 199(2):269-84. doi: 10.1083/jcb.201205119.
Elkins JM, Santaguida S, Musacchio A, Knapp S (2012). Crystal structure of human aurora B in complex with INCENP and VX-680. J Med Chem 55(17):7841-8. doi: 10.1021/jm3008954.
Musacchio A (2012). Andrea Musacchio. Curr Biol 22(14):R552-4. http://dx.doi.org/10.1016/j.cub.2012.06.024
Krenn V, Wehenkel A, Li X, Santaguida S, Musacchio A (2012). Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction. J Cell Biol 196(4):451-67. doi: 10.1083/jcb.201110013.
DeLuca JG, Musacchio A (2012). Structural organization of the kinetochore-microtubule interface. Curr Opin Cell Biol 24(1):48-56. doi: 10.1016/j.ceb.2011.11.003.
Kwiatkowski N, Deng X, Wang J, Tan L, Villa F, Santaguida S, Huang HC, Mitchison T, Musacchio A, Gray N (2012). Selective aurora kinase inhibitors identified using a taxol-induced checkpoint sensitivity screen. ACS Chem Biol 7(1):185-96. doi: 10.1021/cb200305u.
vor 2011
Alushin GM, Ramey VH, Pasqualato S, Ball DA, Grigorieff N, Musacchio A, Nogales E (2010). The Ndc80 kinetochore complex forms oligomeric arrays along microtubules. Nature. 2010 467(7317):805-10. doi: 10.1038/nature09423.
Musacchio A (2010). Molecular biology. Surfing chromosomes (and Survivin). Science183-4. doi: 10.1126/science.1197261.
Petrovic A, Pasqualato S, Dube P, Krenn V, Santaguida S, Cittaro D, Monzani S, Massimiliano L, Keller J, Tarricone A, Maiolica A, Stark H, Musacchio A (2010). The MIS12 complex is a protein interaction hub for outer kinetochore assembly. J Cell Biol 190(5):835-52. doi: 10.1083/jcb.201002070.
Musacchio A (2010). Cell cycle: deconstructing tension. Curr Biol 20(15):R634-7. doi: 10.1016/j.cub.2010.06.014.
Screpanti E, Santaguida S, Nguyen T, Silvestri R, Gussio R, Musacchio A, Hamel E, De Wulf P (2010). A screen for kinetochore-microtubule interaction inhibitors identifies novel antitubulin compounds. PLoS One5(7):e11603. doi: 10.1371/journal.pone.0011603.
Santaguida S, Tighe A, D'Alise AM, Taylor SS, Musacchio A (2010). Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine. J Cell Biol190(1):73-87. doi: 10.1083/jcb.201001036.
Hewitt L, Tighe A, Santaguida S, White AM, Jones CD, Musacchio A, Green S, Taylor SS (2010).Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex. J Cell Biol190(1):25-34. doi: 10.1083/jcb.201002133. doi: 10.1083/jcb.201002133.
Civril F, Wehenkel A, Giorgi FM, Santaguida S, Di Fonzo A, Grigorean G, Ciccarelli FD, Musacchio A (2010). Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery. Structure 8(5):616-26. doi: 10.1016/j.str.2010.02.014. http://dx.doi.org/10.1016/j.str.2010.02.014
Nezi L, Musacchio A (2009). Sister chromatid tension and the spindle assembly checkpoint. Curr Opin Cell Biol 21(6):785-95. doi: 10.1016/j.ceb.2009.09.007.
Villa F, Capasso P, Tortorici M, Forneris F, de Marco A, Mattevi A, Musacchio A (2009). Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organization. Proc Natl Acad Sci U S A 106(48):20204-9. doi: 10.1073/pnas.0908485106 .
Santaguida S, Musacchio A (2009). The life and miracles of kinetochores. EMBO J 28(17):2511-31. doi: 10.1038/emboj.2009.173.
Trazzi S, Perini G, Bernardoni R, Zoli M, Reese JC, Musacchio A, Della Valle G (2009). The C-terminal domain of CENP-C displays multiple and critical functions for mammalian centromere formation. PLoS One 4(6):e5832. doi: 10.1371/journal.pone.0005832.
DeMoe JH, Santaguida S, Daum JR, Musacchio A, Gorbsky GJ (2009). A high throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel Aurora kinase inhibitor. Cancer Res 69(4):1509-16. doi: 10.1158/0008-5472.CAN-08-3133.
Simonetta M, Manzoni R, Mosca R, Mapelli M, Massimiliano L, Vink M, Novak B, Musacchio A, Ciliberto A (2009). The influence of catalysis on mad2 activation dynamics. PLoS Biol 7(1):e10. doi: 10.1371/journal.pbio.1000010. doi: 10.1371/journal.pbio.1000010.
Civril F, Musacchio A (2008). Spindly attachments. Genes Dev22(17):2302-7. doi: 10.1101/gad.1719208.
Varetti G, Musacchio A (2008). The spindle assembly checkpoint. Curr Biol 18(14):R591-5. Erratum in: Curr Biol. 2008 Sep 23;18(18):1444. doi: 10.1016/j.cub.2008.06.012..
Girdler F, Sessa F, Patercoli S, Villa F, Musacchio A, Taylor S (2008). Molecular basis of drug resistance in aurora kinases. Chem Biol15(6):552-62. doi: 10.1016/j.chembiol.2008.04.013.
Ciferri C, Pasqualato S, Screpanti E, Varetti G, Santaguida S, Dos Reis G, Maiolica A, Polka J, De Luca JG, De Wulf P, Salek M, Rappsilber J, Moores CA, Salmon ED, Musacchio A (2008). Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex. Cell 133(3):427-39. doi: 10.1016/j.cell.2008.03.020.
D'Alise AM, Amabile G, Iovino M, Di Giorgio FP, Bartiromo M, Sessa F, Villa F, Musacchio A, Cortese R (2008). Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells.<í> Mol Cancer Ther 7(5):1140-9. doi: 10.1158/1535-7163.MCT-07-2051.
Andersen CB, Wan Y, Chang JW, Riggs B, Lee C, Liu Y, Sessa F, Villa F, Kwiatkowski N, Suzuki M, Nallan L, Heald R, Musacchio A, Gray NS (2008). Discovery of selective aminothiazole aurora kinase inhibitors. ACS Chem Bioll 3(3):180-92. doi: 10.1021/cb700200w.
Mapelli M, Musacchio A (2007). MAD contortions: conformational dimerization boosts spindle checkpoint signaling. Curr Opin Struct Biol Dec;17(6):716-25. http://dx.doi.org/10.1016/j.sbi.2007.08.011
Maiolica A, Cittaro D, Borsotti D, Sennels L, Ciferri C, Tarricone C, Musacchio A, Rappsilber J (2007. Structural analysis of multiprotein complexes by cross-linking, mass spectrometry, and database searching. Mol Cell Proteomics 6(12):2200-11. 10.1074/mcp.M700274-MCP200
Mapelli M, Massimiliano L, Santaguida S, Musacchio A (2007). The Mad2 conformational dimer: structure and implications for the spindle assembly checkpoint. Cell 131(4):730-43. http://dx.doi.org/10.1016/j.cell.2007.08.049
Derewenda U, Tarricone C, Choi WC, Cooper DR, Lukasik S, Perrina F, Tripathy A, Kim MH, Cafiso DS, Musacchio A, Derewenda ZS (2007). The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly. Structure 15(11):1467-81. http://dx.doi.org/10.1016/j.str.2007.09.015
Ciferri C, Musacchio A, Petrovic A (2007). The Ndc80 complex: hub of kinetochore activity. FEBS Lett 581(15):2862-9. 10.1016/j.febslet.2007.05.012
Taylor SS, Hardwick KG, Sawin KE, Biggins S, Piatti S, Khodjakov A, Rieder CL, Salmon ED, Musacchio A (2007). Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint". Science 316(5827):982; author reply 982. 10.1126/science.1139484
Musacchio A, Salmon ED (2007). The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol (5):379-93. doi: 10.1038/nrm2163
Plyte S, Musacchio A (2007). PLK1 inhibitors: setting the mitotic death trap. Curr Biol 17(8):R280-3. http://dx.doi.org/10.1016/j.cub.2007.02.018
DeLuca JG, Gall WE, Ciferri C, Cimini D, Musacchio A, Salmon ED (2006). Kinetochore microtubule dynamics and attachment stability are regulated by Hec1.Cell127(5):969-82. http://dx.doi.org/10.1016/j.cell.2006.09.047
Nezi L, Rancati G, De Antoni A, Pasqualato S, Piatti S, Musacchio A (2006). Accumulation of Mad2-Cdc20 complex during spindle checkpoint activation requires binding of open and closed conformers of Mad2 in Saccharomyces cerevisiae. J Cell Biol174(1):39-51. 10.1083/jcb.200602109
Vink M, Simonetta M, Transidico P, Ferrari K, Mapelli M, De Antoni A, Massimiliano L, Ciliberto A, Faretta M, Salmon ED, Musacchio A (2006). In vitro FRAP identifies the minimal requirements for Mad2 kinetochore dynamics. Curr Biol 16(8):755-66. http://dx.doi.org/10.1016/j.cub.2006.03.057
Penengo L, Mapelli M, Murachelli AG, Confalonieri S, Magri L, Musacchio A, Di Fiore PP, Polo S, Schneider TR (2006). Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin. Cell 124(6):1183-95. 10.1016/j.cell.2006.02.020
Mapelli M, Filipp FV, Rancati G, Massimiliano L, Nezi L, Stier G, Hagan RS, Confalonieri S, Piatti S, Sattler M, Musacchio A (2006). Determinants of conformational dimerization of Mad2 and its inhibition by p31comet. EMBO J 25(6):1273-84. 10.1038/sj.emboj.7601033
Mesngon MT, Tarricone C, Hebbar S, Guillotte AM, Schmitt EW, Lanier L, Musacchio A, King SJ, Smith DS (2006). Regulation of cytoplasmic dynein ATPase by Lis1. J Neurosci 26(7):2132-9. 10.1523/JNEUROSCI.5095-05.2006
Ciferri C, De Luca J, Monzani S, Ferrari KJ, Ristic D, Wyman C, Stark H, Kilmartin J, Salmon ED, Musacchio A (2005). Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore. J Biol Chem 280(32):29088-95. doi: 10.1074/jbc.M504070200
Ahn JS, Radhakrishnan ML, Mapelli M, Choi S, Tidor B, Cuny GD, Musacchio A, Yeh LA, Kosik KS (2005). Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation. Chem Biol 12(7):811-23. http://dx.doi.org/10.1016/j.chembiol.2005.05.011
Lacy ER, Wang Y, Post J, Nourse A, Webb W, Mapelli M, Musacchio A, Siuzdak G, Kriwacki RW (2005). Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division. J Mol Biol 349(4):764-73. http://dx.doi.org/10.1016/j.jmb.2005.04.019
Sessa F, Mapelli M, Ciferri C, Tarricone C, Areces LB, Schneider TR, Stukenberg PT, Musacchio A (2005). Mechanism of Aurora B activation by INCENP and inhibition by hesperadin. Mol Cell 18(3):379-91. http://dx.doi.org/10.1016/j.molcel.2005.03.031
DeAntoni A, Sala V, Musacchio A (2005). Explaining the oligomerization properties of the spindle assembly checkpoint protein Mad2. Philos Trans R Soc Lond B Biol Sci 360(1455):637-47, discussion 447-8. doi: 10.1098/rstb.2004.1618
Mapelli M, Massimiliano L, Crovace C, Seeliger MA, Tsai LH, Meijer L, Musacchio A (2005). Mechanism of CDK5/p25 binding by CDK inhibitors. J Med Chem 48(3):671-9. 10.1021/jm049323m
De Antoni A, Pearson CG, Cimini D, Canman JC, Sala V, Nezi L, Mapelli M, Sironi L, Faretta M, Salmon ED, Musacchio A (2005). The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint. Curr Biol 15(3):214-25. http://dx.doi.org/10.1016/j.cub.2005.01.038
Tarricone C, Perrina F, Monzani S, Massimiliano L, Kim MH, Derewenda ZS, Knapp S, Tsai LH, Musacchio A (2004). Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase. Neuron 44(5):809-21. http://dx.doi.org/10.1016/j.neuron.2004.11.019
Steensgaard P, Garrè M, Muradore I, Transidico P, Nigg EA, Kitagawa K, Earnshaw WC, Faretta M, Musacchio A (2004). Sgt1 is required for human kinetochore assembly. EMBO Rep 5(6):626-31. Epub 2004 May 7. doi: 10.1038/sj.embor.7400154
Ahn JS, Musacchio A, Mapelli M, Ni J, Scinto L, Stein R, Kosik KS, Yeh LA (2004). Development of an assay to screen for inhibitors of tau phosphorylation by cdk5. J Biomol Screen 9(2):122-31. doi: 10.1177/1087057103260594
Polychronopoulos P, Magiatis P, Skaltsounis AL, Myrianthopoulos V, Mikros E, Tarricone A, Musacchio A, Roe SM, Pearl L, Leost M, Greengard P, Meijer L (2004). Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J Med Chem 47(4):935-46. doi: 10.1021/jm031016d
Meijer L, Skaltsounis AL, Magiatis P, Polychronopoulos P, Knockaert M, Leost M, Ryan XP, Vonica CA, Brivanlou A, Dajani R, Crovace C, Tarricone C, Musacchio A, Roe SM, Pearl L, Greengard P (2003). GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol 10(12):1255-66. http://dx.doi.org/10.1016/j.chembiol.2003.11.010
Mapelli M, Musacchio A (2003). The structural perspective on CDK5. Neurosignals 12(4-5):164-72. DOI:10.1159/000074617
Musacchio A, Hardwick KG (2002). The spindle checkpoint: structural insights into dynamic signalling. Nat Rev Mol Cell Biol 3(10):731-41. doi:10.1038/nrm929
Sironi L, Mapelli M, Knapp S, De Antoni A, Jeang KT, Musacchio A (2002). Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint. EMBO J21(10):2496-506. doi: 10.1093/emboj/21.10.2496
Musacchio A (2002). How SH3 domains recognize proline. Adv Protein Chem 2002;61:211-68. pubmed