Targeting oncogenic Ras action
Research report (imported) 2013 - Max Planck Institute of Molecular Physiology
Gene mutations in our genetic makeup are the major cause of cancer. A gene mutated in one out of three tumors is the Ras gene. Last year scientists at the Max Planck Institute of Molecular Physiology developed a new molecule which targets oncogenic Ras dependent tumors. Instead of focusing on Ras directly, the new molecule targets an interaction partner of Ras that is responsible for its localization within the cell. Inhibition of this interaction partner changes the localization of Ras, and hereby inactivates oncogenic growth signaling.