Prof. Dr. Stefan Raunser
Stefan Raunser, was born 1976 in Landau/Pfalz. He studied chemistry and biology at the Johannes-Gutenberg-Universität Mainz. He prepared his PhD thesis in the group of Werner Kühlbrandt at the Max Planck Institute of Biophysics in Frankfurt/Main and received his PhD in biochemistry at Johann-Wolfgang-Goethe Universität Frankfurt in 2004.
From 2005 to 2008 he was a postdoctoral researcher in the group of Thomas Walz at Harvard Medical School in Boston, USA and from 2008 to 2013 he was Emmy Noether group leader at the Max Planck Institute of Molecular Physiology in Dortmund. From January to June 2014 he was Einstein-Professor for Membrane Biochemistry at Freie Universität Berlin.
Since July 2014 he is director and Scientific Member at the Max Planck Institute of Molecular Physiology in Dortmund.
In March 2015 he became honorary Professor at the Faculty of Biology at the University Duisburg Essen and since May 2015 he is Adjunct Professor at the Faculty of Chemistry and Biology at the TU Dortmund University.
Raunser has been a member of the scientific organisation EMBO since 2018. Since 2019 he is a member of the German National Academy of Sciences Leopoldina and in 2022 he was elected to the North Rhine-Westphalian Academy of Sciences, Humanities and Arts.
Stefan Raunser received an ERC Consolidator Grant in 2014 and an ERC Synergy Grant in 2019.
Vita
Education
2001 – 2004
PhD in Biochemistry, University of Frankfurt, Germany, Supervisor: Dr. Werner Kühlbrandt,
Max Planck Institute of Biophysics, Frankfurt, Germany
1995 – 2000
Diploma degree (equivalent to M.Sc.) in Biology, University of Mainz, Germany
First German State Examination in Chemistry and Biology, University of Mainz, Germany
Supervisor of diploma thesis: Dr. H. Paulsen, University of Mainz, Germany
1995
Abitur with specialization in Biology, Chemistry and English
Current Positions
2015 – now
Honorary Professor, University of Duisburg-Essen, Germany
2015 – now
Adjunct Professor, Technical University Dortmund, Germany
2014 – now
Director, Department of Structural Biochemistry,
Max Planck Institute of Molecular Physiology, Dortmund, Germany
Previous Positions
2014
Full Professor, Department of Chemistry/Biology/Pharmacy,
Freie Universität Berlin, Germany
2008 – 2013
Independent Group Leader, Department of Physical Biochemistry,
Max Planck Institute of Molecular Physiology, Dortmund, Germany
2005 –2008
Postdoctoral Researcher in the laboratory of Dr. T. Walz,
HHMI, Department of Cell Biology, Harvard Medical School, Boston, USA
Fellowships and Awards
2022
Member of the North Rhine-Westphalian Academy of Sciences and Arts
2020
ERC Synergy Grant (together with D. Görlich, F. Schnorrer, M. Gautel)
2019
Member of the German National Academy of Sciences Leopoldina
2016
Randall Lecture – King’s College London University
2014
ERC Consolidator Grant
2013
Einstein-Professorship of the Einstein Foundation Berlin
2011 – 2014
Member of the “Junges Kolleg” (Academy of Sciences and Arts of North Rhine-Westphalia)
2009 – 2011
Member of the Global Young Faculty; Speaker of the Health group
2008 – 2013
Emmy-Noether Fellowship German Research Foundation (DFG)
2007 – 2008
Fellow of the German Academy of Sciences “Leopoldina”
2005 – 2006
Fellow of Harvard Medical School
2001 – 2004
Fellow of the German National Academic Foundation
1999
Fellow of the Johannes-Gutenberg University Foundation
1998 – 1999
Erasmus Fellow of the European Union
1995
Winner of the “Jugend forscht” competition in Palatinate
Selected Publications 2013-2024
> Publication list 01/2024 as PDF
Tamborrini D, Wang Z, Wagner T, Tacke S, Stabrin S, Grange M, Kho AL, Rees M, Bennet P, Gautel M, Raunser S (2023). Structure of the native myosin filament in the relaxed cardiac sarcomere. Nature
Quelle
Rice G, Wagner T, Stabrin M, Sitsel O, Prumbaum D, Raunser S (2023). TomoTwin: generalized 3D localization of macromolecules in cryo-electron tomograms with structural data mining. Nature Methods
Quelle
Oosterheert W, Klink B. U, Belyy A, Pospich S, Raunser S (2022). Structural Basis of actin filament assembly and aging. Nature
Quelle
Wang Z, Grange M, Pospich S, Wagner T, Kho A.L, Gautel M, Raunser S (2022). Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin. Science
Source
Wang Z, Grange M, Wagner T, Khoo AL, Gautel M, Raunser S (2021). The molecular basis for sarcomere organization in vertebrate skeletal muscle Cell
Source
Gatsogiannis C, Balogh D, Merino F, Sieber SA, Raunser S (2019). Cryo-EM structure of the ClpXP protein degradation machinery. Nat Struct Mol Bio
doi: 10.1038/s41594-019-0304-0.
Raisch T, Chang CT, Levdansky Y, Muthukumar S, Raunser S, Valkov E (2019). Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation. Nature Communications
doi: 10.1038/s41467-019-11094-z.
Gatsogiannis C, Merino F, Roderer D, Balchin D, Schubert E, Kuhlee A, Hayer-Hartl M, Raunser S. (2018). Tc toxin activation requires unfolding and refolding of a β-propeller. Nature
doi: 10.1038/s41586-018-0556-6.
Vinayagam D, Mager T, Apelbaum A, Bothe A, Merino F, Hofnagel O, Gatsogiannis C, Raunser S (2018). Electron cryo-microscopy structure of the canonical TRPC4 ion channel. eLife
doi: 10.7554/eLife.36615.
Klink BU, Zent E, Juneja P, Kuhlee A, Raunser S, Wittinghofer A. (2017). A recombinant BBSome core complex and how it interacts with ciliary cargo. eLife
doi: 10.7554/eLife.27434.
Pospich S, Kumpula EP, von der Ecken J, Vahokoski J, Kursula I, Raunser S. (2017). Near-atomic structure of jasplakinolide-stabilized malaria parasite F-actin reveals the structural basis of filament instability. Proc Natl Acad Sci U S A
doi: 10.1073/pnas.1707506114
von der Ecken J, Heissler SM, Pathan-Chhatbar S, Manstein DJ & Raunser S (2016).Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution. Nature 534(7609):724-28.
doi: 10.1038/nature18295
freely available!
Gatsogiannis C, Merino F, Serdiuk T, Prumbaum D, Roderer D, Leidreiter F, Meusch D, Müller DJ, and Raunser S (2016). Membrane insertion of a Tc toxin in atomic detail. Nature Structural and Molecular Biology 23(10):884-890.
doi: 10.1038/nsmb.3281
freely available!
Gatsogiannis C, Hofnagel O, Markl J, Raunser S (2015). Structure of Mega-Hemocyanin reveals protein origami in snails. Structure 23(1):93-103.
doi: 10.1016/j.str.2014.10.013
Efremov R, Hofnagel O, Raunser S (2015). Architecture and Conformational Switch Mechanism of the Ryanodine Receptor. Nature 517(7532):39-43.
doi: 10.1038/nature13916
freely available!
Whitney JC, Quentin D, Sawai S, LeRoux M, Harding BN, Ledvina HE, Tran BQ, Robinson H, Goo YA, Goodlett DR, Raunser S, Mougous JD (2015). An Interbacterial NAD(P)(+) Glycohydrolase Toxin Requires Elongation Factor Tu for Delivery to Target Cells. Cell 163(3):607-19.
doi: 10.1016/j.cell.2015.09.027
von der Ecken J, Müller M, Lehman W, Manstein DJ, Penczek PA, Raunser S (2015). Structure of the F-actin-tropomyosin complex. Nature 519(7541):114-7.
doi: 10.1038/nature14033
freely available!
Meusch D, Gatsogiannis C, Efremov R, Lang A, Hofnagel O, Vetter I, Aktories K, Raunser S (2014). Mechanism of Tc toxin action revealed in molecular detail. Nature 508(7494):61-5.
doi: 10.1038/nature13015
freely available!
Gatsogiannis C, Lang A, Meusch D, Pfaumann V, Hofnagel O, Benz R, Aktories K, Raunser S (2013). A syringe-like injection mechanism in Photorhabdus luminescens toxins. Nature. 495(7442):520-23
doi: 10.1038/nature11987
freely available!