Publications of Daniel Rauh

Antonchick, A. P.; Gerding-Reimers, C.; Catarinella, M.; Schürmann, M.; Preut, H.; Ziegler, S.; Rauh, D.; Waldmann, H.: Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products. Nature Chemistry 2 (9), 1, pp. 735 - 740 (2010)

Simard, J. R.; Getlik, M.; Grütter, C.; Schneider, R.; Wulfert, S.; Rauh, D.: Fluorophore Labeling of the Glycine-Rich Loop as a Method of Identifying Inhibitors That Bind to Active and Inactive Kinase Conformations. Journal of the American Chemical Society 132 (12), 1, pp. 4152 - 4160 (2010)

Dekker, F. J.; Rocks, O.; Vartak, N.; Menninger, S.; Hedberg, C.; Balamurugan, R.; Wetzel, S.; Renner, S.; Gerauer, M.; Schölermann, B. et al.; Rusch, M.; Kramer, J. W.; Rauh, D.; Coates, G. W.; Brunsveld, L.; Bastiaens, P. I. H.; Waldmann, H.: Small-molecule inhibition of APT1 affects Ras localization and signaling. Nature Chemical Biology 6 (6), 1, pp. 449 - 456 (2010)

Pawar, V. G.; Sos, M. L.; Rode, H. B.; Rabiller, M.; Heynck, S.; Van Otterlo, W. A. L.; Thomas, R. K.; Rauh, D.: Synthesis and Biological Evaluation of 4-Anilinoquinolines as Potent Inibitors of Epidermal Growth Factor Receptor. Journal of Medicinal Chemistry 53 (7), 1, pp. 2892 - 2901 (2010)

Rauh, D.: Inaktive Kinasekonformationen stabilisieren. Nachrichten aus der Chemie 58 (2), 1, pp. 118 - 121 (2010)

Peifer, M.; Weiss, J.; Sos, M. L.; Koker, M.; Heynck, S.; Netzer, C.; Fischer, S.; Rode, H.; Rauh, D.; Rahnenführer, J. et al.; Thomas, R. K.: Analysis of Compound Synergy in High-Throughput Cellular Screens by Population-Based Lifetime Modeling. PLoS ONE 5 (1), 1, p. e8919 (2010)

Klüter, S.; Grütter, C.; Naqvi, T.; Rabiller, M.; Simard, J. R.; Pawar, V.; Getlik, M.; Rauh, D.: Displacement Assay for the Detection of Stabilizers of Inactive Kinase Conformations. Journal of Medicinal Chemistry 53 (1), 1, pp. 357 - 367 (2010)

Rabiller, M.; Getlik, M.; Klüter, S.; Richters, A.; Tückmantel, S.; Simard, J. R.; Rauh, D.: Proteus in the World of Proteins: Conformational Changes in Protein Kinases. Archiv der Pharmazie 343 (4), 1, pp. 193 - 206 (2010)

Rauh, D.: Inaktive Kinasekonformationen stabilisieren. Nachrichten aus der Chemie 58 (2), 1, pp. 118 - 122 (2010)

Sos, M. L.; Rode, H. B.; Heynck, S.; Peifer, M.; Fischer, F.; Klüter, S.; Pawar, V. G.; Reuter, C.; Heuckmann, J. M.; Weiss, J. et al.; Ruddigkeit, L.; Rabiller, M.; Koker, M.; Simard, J. R.; Getlik, M.; Yuza, Y.; Chen, T.-H.; Greulich, H.; Thomas, R. K.; Rauh, D.: Chemogenomic Profiling Provides Insights into the Limited Activity of Irreversible EGFR Inhibitors in Tumor Cells Expressing the T790M EGFR Resistance Mutation. Cancer Research 70 (3), 1, pp. 868 - 874 (2010)

Vintonyak, V. V.; Warburg, K.; Kruse, H.; Grimme, S.; Hübel, K.; Rauh, D.; Waldmann, H.: Identification of Thiazolidinones Spiro-Fused to Indolin-2-ones as Potent and Selective Inhibitors of the Mycobacterium tuberculosis Protein Tyrosine Phosphatase B. Angewandte Chemie International Edition 49 (34), 1, pp. 5902 - 5905 (2010)

Wetzel, S.; Wilk, W.; Chammaa, S.; Sperl, B.; Roth, A. G.; Yektaoglu, A.; Renner, S.; Berg, T.; Arenz, C.; Giannis, A. et al.; Oprea, T. I.; Rauh, D.; Kaiser, M.; Waldmann, H.: A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-Pyrones. Angewandte Chemie International Edition 49 (21), 1, pp. 3666 - 3670 (2010)

Sos, M. L.; Fischer, S.; Ullrich, R.; Peifer, M.; Heuckmann, J. M.; Koker, M.; Heynck, S.; Stückrath, I.; Weiss, J.; Fischer, F. et al.; Michel, K.; Goel, A.; Regales, L.; Politi, K. A.; Perera, S.; Getlik, M.; Heukamp, L. C.; Ansén, S.; Zander, T.; Beroukhim, R.; Kashkar, H.; Shokat, K. M.; Sellers, W. R.; Rauh, D.; Orr, C.; Hoeflich, K. P.; Friedman, L.; Wong, K.-K.; Pao, W.; Thomas, R. K.: Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer. Proceedings of the National Academy of Sciences of the United States of America 106 (43), 1, pp. 18351 - 18356 (2009)

Simard, J. R.; Rauh, D.: Chemical and Structural Biology to Direct the Repurposing of Sulindac. ChemMedChem 4 (11), 1, pp. 1793 - 1795 (2009)

Simard, J. R.; Getlik, M.; Grütter, C.; Pawar, V.; Wulfert, S.; Rabiller, M.; Rauh, D.: Development of a Fluorescent-Tagged Kinase Assay System for the Detection and Characterization of Allosteric Kinase Inhibitors. Journal of the American Chemical Society 131 (37), 1, pp. 13286 - 13296 (2009)

Renner, S.; Van Otterlo, W. A. L.; Dominguez Seoane, M.; Möcklinghoff, S.; Hofmann, B.; Wetzel, S.; Schuffenhauer, A.; Ertl, P.; Oprea, T. I.; Steinhilber, D. et al.; Brunsveld, L.; Rauh, D.; Waldmann, H.: Bioactivity-guided mapping and navigation of chemical space. Nature Chemical Biology 5 (8), 1, pp. 585 - 592 (2009)

Wetzel, S.; Klein, K.; Renner, S.; Rauh, D.; Oprea, T. I.; Mutzel, P.; Waldmann, H.: Interactive Exploration of Chemical Space with Scaffold Hunter. Nature Chemical Biology 5 (8), 1, pp. 581 - 583; 696 (2009)

Vintonyak, V. V.; Antonchick, A. P.; Rauh, D.; Waldmann, H.: The therapeutic potential of phosphatase inhibitors. Current Opinion in Chemical Biology 13 (3), 1, pp. 272 - 283 (2009)

Getlik, M.; Grütter, C.; Simard, J. R.; Klüter, S.; Rabiller, M.; Rode, H. B.; Robubi, A.; Rauh, D.: Hybrid Compound Design to Overcome the Gatekeeper T338M Mutation in cSrc. Journal of Medicinal Chemistry 52 (13), 1, pp. 3915 - 3926 (2009)

Simard, J. R.; Klüter, S.; Grütter, C.; Getlik, M.; Rabiller, M.; Rode, H. B.; Rauh, D.: A new screening assay for allosteric inhibitors of cSrc. Nature Chemical Biology 5 (6), 1, pp. 394 - 396 (2009)