Publications of A. Wittinghofer

Kuhn, K.; Owen, D. J.; Bader, B.; Wittinghofer, A.; Kuhlmann, J.; Waldmann, H.: Synthesis of Functional Ras Lipoproteins and Fluorescent Derivates. Journal of the American Chemical Society 123, pp. 1023 - 1035 (2001)

Bader, B.; Kuhn, K.; Owen, D.; Waldmann, H.; Wittinghofer, A.; Kuhlmann, J.: Bioorganic synthesis of lipid-modified proteins for the study of signal transduction. NATURE 403 (6766), pp. 223 - 226 (2000)

Wittinghofer, A.; Gierschik, P.: Highlight: GTP binding proteins - Central regulators in cell biology. Biological Chemistry 381 (5-6), 1, p. 355 - 355 (2000)

Wittinghofer, A.; Waldmann, H.: Ras - A molecular switch involved in tumor formation. Angewandte Chemie International Edition in English 39 (23), 1, pp. 4193 - 4214 (2000)

Ahmadian, M. R.; Zor, T.; Vogt, D.; Kabsch, W.; Selinger, Z.; Wittinghofer, A.; Scheffzek, K.: Guanosine triphosphatase stimulation of oncogenic Ras mutants. Proceedings of the National Academy of Sciences of the United States of America 96 (12), 1, pp. 7065 - 7070 (1999)

Schelhaas, M.; Nagele, E.; Kuder, N.; Bader, B.; Kuhlmann, J.; Wittinghofer, A.; Waldmann, H.: Chemoenzymatic synthesis of biotinylated Ras peptides and their use in membrane binding studies of lipidated model proteins by surface plasmon resonance. CHEMISTRY-A EUROPEAN JOURNAL 5 (4), pp. 1239 - 1252 (1999)

Ahmadian, M. R.; Zor, T.; Vogt, D.; Kabsch, W.; Selinger, Z.; Wittinghofer, A.; Scheffzek, K.: Guanosine triphosphatase stimulation of oncogenic Ras mutants. Proceedings of the National Academy of Sciences of the United States of America 96 (12), pp. 7065 - 7070 (1999)

Scheffzek, K.; Ahmadian, M. R.; Wittinghofer, A.: GTPase-activating proteins: helping hands to complement an active site. Trends in Biochemical Sciences 23 (7), 1, pp. 257 - 262 (1998)

Ahmadian, M. R.; Mittal, R.; Hall, A.; Wittinghofer, A.: Aluminium fluoride associates with the small guanine nucleotide binding proteins. FEBS Letters 408 (3), 1, pp. 315 - 318 (1997)

Ahmadian, M. R.; Hoffmann, U.; Goody, R. S.; Wittinghofer, A.: Individual rate constants for the interaction of Ras proteins with GTPase-activating proteins determined by fluorescence spectroscopy. Biochemistry 36 (15), 1, pp. 4535 - 4541 (1997)

Ahmadian, M. R.; Hoffmann, U.; Goody, R. S.; Wittinghofer, A.: Individual rate constants for the interaction of Ras proteins with GTPase-activating proteins determined by fluorescence spectroscopy. Biochemistry 36 (15), pp. 4535 - 4541 (1997)

Ahmadian, M. R.; Stege, P.; Scheffzek, K.; Wittinghofer, A.: Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras. Nature Structural Biology 4 (9), 1, pp. 686 - 689 (1997)

Ahmadian, M. R.; Stege, P.; Scheffzek, K.; Wittinghofer, A.: Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras. Nature structural biology 4, pp. 686 - 689 (1997)

Geyer, M.; Herrmann, C.; Wohlgemuth, S.; Wittinghofer, A.; Kalbitzer, H. R.: Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling. Nature structural biology 4, pp. 694 - 699 (1997)

Geyer, M.; Wittinghofer, A.: GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP binding proteins. Current Opinion in Structural Biology 7 (6), pp. 786 - 792 (1997)

Jaitner, B. K.; Becker, J.; Linnemann, T.; Herrmann, C.; Wittinghofer, A.; Block, C.: Discrimination of amino acids mediating Ras binding from noninteracting residues affecting Raf activation by double mutant analysis. The Journal of Biological Chemistry 272, pp. 29927 - 29933 (1997)

Kuhlmann, J.; Macara, I.; Wittinghofer, A.: Dynamic and equilibrium studies on the interaction of Ran with its effector, RanBP1. Biochemistry 36 (40), pp. 12027 - 12035 (1997)

Scheffzek, K.; Ahmadian, M. R.; Kabsch, W.; Wiesmüller, L.; Lautweit, A.; Schmitz, F.; Wittinghofer, A.: The Ras-RasGAP complex: Structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science 277 (5324), pp. 333 - 338 (1997)

Scheffzek, K.; Lautwein, A.; Scherer, A.; Franken, S.; Wittinghofer, A.: Crystallization and preliminary X-ray crystallographic study of the Ras-GTPase-activating domain of human p120GAP. Proteins: Structure, Function, and Genetics 27 (2), pp. 315 - 318 (1997)

Schweins, T.; Scheffzek, K.; Assheuer, R.; Wittinghofer, A.: The role of the metal ion in the p21^ras catalysed GTP-hydrolysis: Mn²⁺ versus Mg²⁺. Journal of Molecular Biology 266 (4), pp. 847 - 856 (1997)