Publications of Alfred Wittinghofer

Wolber, V.; Rensland, H.; Brandmeier, B.; Sagemann, M.; Hoffmann, R.; Kalbitzer, H. R.; Wittinghofer, A.: EXPRESSION, PURIFICATION AND BIOCHEMICAL-CHARACTERIZATION OF THE HUMAN IMMUNODEFICIENCY VIRUS-1 NEF GENE-PRODUCT. EUROPEAN JOURNAL OF BIOCHEMISTRY 205 (3), pp. 1115 - 1121 (1992)

Bock-Möbius, I.; Brune, M.; Wittinghofer, A.; Zimmermann, H.; Leberman, R.; Dauvergne, M.-T.; Zimmermann, S.; Brandmeier, B.; Rösch, P.: IDENTIFICATION OF VALINE/LEUCINE/ISOLEUCINE AND THREONINE/ALANINE/GLYCINE PROTON-SPIN SYSTEMS OF ESCHERICHIA COLI ADENYLATE KINASE BY SELECTIVE DEUTERATION AND SELECTIVE PROTONATION. BIOCHEMICAL JOURNAL 273, pp. 311 - 316 (1991)

Goody, R. S.; Frech, M.; Wittinghofer, A.: AFFINITY OF GUANINE-NUCLEOTIDE BINDING-PROTEINS FOR THEIR LIGANDS - FACTS AND ARTIFACTS. TRENDS IN BIOCHEMICAL SCIENCES 16 (9), pp. 327 - 328 (1991)

Hescheler, J.; Klinz, F.-J.; Schultz, G.; Wittinghofer, A.: RAS PROTEINS ACTIVATE CALCIUM CHANNELS IN NEURONAL CELLS. CELLULAR SIGNALLING 3 (2), pp. 127 - 133 (1991)

Kalbitzer, H. R.; Maeda, K.; Rösch, A.; Maeda, Y.; Geyer, M.; Beneicke, W.; Neidig, K.-P.; Wittinghofer, A.: C-TERMINAL STRUCTURE AND MOBILITY OF RABBIT SKELETAL-MUSCLE LIGHT-MEROMYOSIN AS STUDIED BY ONE-DIMENSIONAL AND 2-DIMENSIONAL ¹H NMR SPECTROSCOPY AND X-RAY SMALL-ANGLE SCATTERING. BIOCHEMISTRY 30 (32), pp. 8083 - 8091 (1991)

Kalbitzer, H. R.; Wittinghofer, A.: THE EFFECT OF KIRROMYCIN ON THE METAL-ION COORDINATION IN COMPLEXES OF ELONGATION FACTOR-TU FROM BACILLUS STEAROTHERMOPHILUS AS INFERRED FROM THE ¹⁷O-⁵⁵MN-SUPERHYPERFINE INTERACTION. BIOCHIMICA ET BIOPHYSICA ACTA 1078 (2), pp. 133 - 138 (1991)

Maeda, K.; Rösch, A.; Maeda, Y.; Kalbitzer, H. R.; Wittinghofer, A.: RABBIT SKELETAL MUSCLE MYOSIN - UNFOLDED CARBOXYL-TERMINUS AND ITS ROLE IN MOLECULAR ASSEMBLY. FEBS LETTERS 281 (1-2), pp. 23 - 26 (1991)

Reinstein, J.; Schlichting, I.; Frech, M.; Goody, R. S.; Wittinghofer, A.: P21 WITH A PHENYLALANINE 28->LEUCINE MUTATION REACTS NORMALLY WITH THE GTPASE ACTIVATING PROTEIN GAP BUT NEVERTHELESS HAS TRANSFORMING PROPERTIES. JOURNAL OF BIOLOGICAL CHEMISTRY 266 (26), pp. 17700 - 17706 (1991)

Rensland, H.; Lautwein, A.; Wittinghofer, A.; Goody, R. S.: IS THERE A RATE-LIMITING STEP BEFORE GTP CLEAVAGE BY H-RAS P21? BIOCHEMISTRY 30 (46), pp. 11181 - 11185 (1991)

Rose, T.; Brune, M.; Wittinghofer, A.; Le Blay, K.; Surewicz, W. K.; Mantcsh, H. H.; Barzu, O.; Gilles, A.-M.: STRUCTURAL AND CATALYTIC PROPERTIES OF A DELETION DERIVATIVE (DELTA_133-157) OF ESCHERICHIA-COLI ADENYLATE KINASE. JOURNAL OF BIOLOGICAL CHEMISTRY 266 (17), pp. 10781 - 10786 (1991)

Serth, J.; Lautwein, A.; Frech, M.; Wittinghofer, A.; Pingoud, A.: THE INHIBITION OF THE GTPASE ACTIVATING PROTEIN-HA-RAS INTERACTION BY ACIDIC LIPIDS IS DUE TO PHYSICAL ASSOCIATION OF THE C-TERMINAL DOMAIN OF THE GTPASE ACTIVATING PROTEIN WITH MICELLAR STRUCTURES. EMBO JOURNAL 10 (6), pp. 1325 - 1330 (1991)

Valencia, A.; Chardin, P.; Wittinghofer, A.; Sander, C.: THE RAS PROTEIN FAMILY: EVOLUTIONARY TREE AND ROLE OF CONSERVED AMINO ACIDS. BIOCHEMISTRY 30 (19), pp. 4637 - 4648 (1991)

Wittinghofer, A.; Pai, E. F.: THE STRUCTURE OF RAS PROTEIN - A MODEL FOR A UNIVERSAL MOLECULAR SWITCH. TRENDS IN BIOCHEMICAL SCIENCES 16 (10), pp. 382 - 387 (1991)

Frech, M.; John, J.; Pizon, V.; Chardin, P.; Tavitian, A.; Clark, R.; McCormick, F.; Wittinghofer, A.: INHIBITION OF GTPASE ACTIVATING PROTEIN STIMULATION OF RAS-P21 GTPASE BY THE KREV-1 GENE-PRODUCT. SCIENCE 249 (4965), pp. 169 - 171 (1990)

Frech, M.; Schlichting, I.; Wittinghofer, A.; Chardin, P.: GUANINE NUCLEOTIDE BINDING PROPERTIES OF THE MAMMALIAN RALA PROTEIN PRODUCED IN ESCHERICHIA COLI. JOURNAL OF BIOLOGICAL CHEMISTRY 265 (11), pp. 6353 - 6359 (1990)

John, J.; Sohmen, R.; Feuerstein, J.; Linke, R.; Wittinghofer, A.; Goody, R. S.: KINETICS OF INTERACTION OF NUCLEOTIDES WITH NUCLEOTIDE-FREE H-RAS P21. BIOCHEMISTRY 29 (25), pp. 6058 - 6065 (1990)

Kalbitzer, H. R.; Feuerstein, J.; Goody, R. S.; Wittinghofer, A.: STEREOCHEMISTRY AND LIFETIME OF THE GTP HYDROLYSIS INTERMEDIATE AT THE ACTIVE SITE OF ELONGATION FACTOR TU FROM BACILLUS STEAROTHERMOPHILUS AS INFERRED FROM THE ¹⁷O-⁵⁵Mn SUPERHYPERFINE INTERACTION. EUROPEAN JOURNAL OF BIOCHEMISTRY 188 (2), pp. 355 - 359 (1990)

Krengel, U.; Schlichting, I.; Scherer, A.; Schumann, R.; Frech, M.; John, J.; Kabsch, W.; Pai, E. F.; Wittinghofer, A.: THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS - MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES. CELL 62 (3), pp. 539 - 548 (1990)

Maeda, K.; Müller-Gerhardt, E.; Wittinghofer, A.: SEQUENCE OF 2 ISOFORMS OF MYOSIN LIGHT CHAIN-2 ISOLATED FROM A RABBIT FAST SKELETAL MUSCLE LAMBDA LIBRARY. NUCLEIC ACIDS RESEARCH 18 (22), p. 6687 - 6687 (1990)

Müller, B.; Maeda, K.; Wittinghofer, A.: SEQUENCE OF THE MYOSIN LIGHT CHAIN 1/3 ISOLATED FROM A RABBIT FAST SKELETAL-MUSCLE LAMBDA LIBRARY. NUCLEIC ACIDS RESEARCH 18 (22), p. 6688 - 6688 (1990)