Publications of Alfred Wittinghofer

Pai, E. F.; Krengel, U.; Petsko, G. A.; Goody, R. S.; Kabsch, W.; Wittinghofer, A.: REFINED CRYSTAL STRUCTURE OF THE TRIPHOSPHATE CONFORMATION OF H-RAS P21 AT 1.35 A RESOLUTION: IMPLICATIONS FOR THE MECHANISM OF GTP HYDROLYSIS. EMBO JOURNAL 9 (8), pp. 2351 - 2359 (1990)

Saraste, M.; Sibbald, P. R.; Wittinghofer, A.: THE P-LOOP - A COMMON MOTIF IN ATP-BINDING AND GTP-BINDING PROTEINS. TRENDS IN BIOCHEMICAL SCIENCES 15 (11), pp. 430 - 434 (1990)

Schlichting, I.; Almo, S. C.; Rapp, G.; Wilson, K.; Petratos, K.; Lentfer, A.; Wittinghofer, A.; Kabsch, W.; Pai, E. F.; Petsko, G. A. et al.; Goody, R. S.: TIME-RESOLVED X-RAY CRYSTALLOGRAPHIC STUDY OF THE CONFORMATIONAL CHANGE IN HA-RAS P21 PROTEIN ON GTP HYDROLYSIS. NATURE 345 (6273), pp. 309 - 315 (1990)

Schlichting, I.; John, J.; Frech, M.; Chardin, P.; Wittinghofer, A.; Zimmermann, H.; Rösch, P.: PROTON NMR-STUDIES OF TRANSFORMING AND NONTRANSFORMING H-RAS P21 MUTANTS. BIOCHEMISTRY 29 (2), pp. 504 - 511 (1990)

Borasio, G. D.; John, J.; Wittinghofer, A.; Barde, Y.-A.; Sendtner, M.; Heumann, R.: RAS P21-PROTEIN PROMOTES SURVIVAL AND FIBER OUTGROWTH OF CULTURED EMBRYONIC NEURONS. NEURON 2 (1), pp. 1087 - 1096 (1989)

Haase, G. H. W.; Brune, M.; Reinstein, J.; Pai, E. F.; Pingoud, A.; Wittinghofer, A.: ADENYLATE KINASES FROM THERMOSENSITIVE ESCHERICHIA-COLI STRAINS. JOURNAL OF MOLECULAR BIOLOGY 207 (1), pp. 151 - 162 (1989)

John, J.; Schlichting, I.; Schiltz, E.; Rösch, P.; Wittinghofer, A.: C-TERMINAL TRUNCATION OF P21H PRESERVES CRUCIAL KINETIC AND STRUCTURAL-PROPERTIES. JOURNAL OF BIOLOGICAL CHEMISTRY 264 (22), pp. 13086 - 13092 (1989)

Maeda, K.; Sczakiel, G.; Hofmann, W.; Menetret, J.-F.; Wittinghofer, A.: EXPRESSION OF NATIVE RABBIT LIGHT-MEROMYOSIN IN ESCHERICHIA-COLI - OBSERVATION OF A POWERFUL INTERNAL TRANSLATION INITIATION SITE. JOURNAL OF MOLECULAR BIOLOGY 205 (1), pp. 269 - 273 (1989)

Pai, E. F.; Kabsch, W.; Krengel, U.; Holmes, K. C.; John, J.; Wittinghofer, A.: STRUCTURE OF THE GUANINE-NUCLEOTIDE-BINDING DOMAIN OF THE HA-RAS ONCOGENE PRODUCT P21 IN THE TRIPHOSPHATE CONFORMATION. NATURE 341 (6239), pp. 209 - 214 (1989)

Reinstein, J.; Gilles, A.-M.; Rose, T.; Wittinghofer, A.; Girons, I. S.; Barzu, O.; Surewicz, W. K.; Mantsch, H. H.: STRUCTURAL AND CATALYTIC ROLE OF ARGININE-88 IN ESCHERICHIA-COLI ADENYLATE KINASE AS EVIDENCED BY CHEMICAL MODIFICATION AND SITE-DIRECTED MUTAGENESIS. JOURNAL OF BIOLOGICAL CHEMISTRY 264 (14), pp. 8107 - 8112 (1989)

Scherer, A.; John, J.; Linke, R.; Goody, R. S.; Wittinghofer, A.; Pai, E. F.; Holmes, K. C.: CRYSTALLIZATION AND PRELIMINARY-X-RAY ANALYSIS OF THE HUMAN C-H-RAS-ONCOGENE PRODUCT P21 COMPLEXED WITH GTP ANALOGS. JOURNAL OF MOLECULAR BIOLOGY 206 (1), pp. 257 - 259 (1989)

Schlichting, I.; Rapp, G.; John, J.; Wittinghofer, A.; Pai, E. F.; Goody, R. S.: BIOCHEMICAL AND CRYSTALLOGRAPHIC CHARACTERIZATION OF A COMPLEX OF C-HA-RAS P21 AND CAGED GTP WITH FLASH PHOTOLYSIS - (TIME-RESOLVED STRUCTURE). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86 (20), pp. 7687 - 7690 (1989)

Bock, I.; Reinstein, J.; Brune, M.; Wittinghofer, A.; Rösch, P.: PROTON-NUCLEAR MAGNETIC-RESONANCE STUDIES OF THE AROMATIC SPIN SYSTEMS OF ESCHERICHIA-COLI ADENYLATE KINASE. JOURNAL OF MOLECULAR BIOLOGY 200 (4), pp. 745 - 748 (1988)

John, J.; Frech, M.; Wittinghofer, A.: BIOCHEMICAL-PROPERTIES OF HA-RAS ENCODED P21-MUTANTS AND MECHANISM OF THE AUTOPHOSPHORYLATION REACTION. JOURNAL OF BIOLOGICAL CHEMISTRY 263 (24), pp. 11792 - 11799 (1988)

Pingoud, A.; Wehrmann, M.; Pieper, U.; Gast, F.-U.; Urbanke, C.; Alves, J.; Feuerstein, J.; Wittinghofer, A.: SPECTROSCOPIC AND HYDRODYNAMIC STUDIES REVEAL STRUCTURAL DIFFERENCES IN NORMAL AND TRANSFORMING H-RAS GENE-PRODUCTS. BIOCHEMISTRY 27 (13), pp. 4735 - 4740 (1988)

Reinstein, J.; Brune, M.; Wittinghofer, A.: MUTATIONS IN THE NUCLEOTIDE BINDING LOOP OF ADENYLATE KINASE OF ESCHERICHIA-COLI. BIOCHEMISTRY 27 (13), pp. 4712 - 4720 (1988)

Schlichting, I.; Wittinghofer, A.; Rösch, P.: PROTON NMR-STUDIES OF THE GDP MG-2+ COMPLEX OF THE HA-RAS ONCOGENE PRODUCT-P21. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 150 (1), pp. 444 - 448 (1988)

Feuerstein, J.; Goody, R. S.; Wittinghofer, A.: PREPARATION AND CHARACTERIZATION OF NUCLEOTIDE-FREE AND METAL ION-FREE P21 APOPROTEIN. JOURNAL OF BIOLOGICAL CHEMISTRY 262 (18), pp. 8455 - 8458 (1987)

Feuerstein, J.; Kalbitzer, H. R.; John, J.; Goody, R. S.; Wittinghofer, A.: CHARACTERIZATION OF THE METAL-ION - GDP COMPLEX AT THE ACTIVE-SITES OF TRANSFORMING AND NONTRANSFORMING P21 PROTEINS BY OBSERVATION OF THE (O-MN)-O-17 SUPERHYPERFINE COUPLING AND BY KINETIC METHODS. EUROPEAN JOURNAL OF BIOCHEMISTRY 162 (1), pp. 49 - 55 (1987)

Maeda, K.; Sczakiel, G.; Wittinghofer, A.: CHARACTERIZATION OF CDNA CODING FOR THE COMPLETE LIGHT-MEROMYOSIN PORTION OF A RABBIT FAST SKELETAL-MUSCLE MYOSIN HEAVY-CHAIN. EUROPEAN JOURNAL OF BIOCHEMISTRY 167 (1), pp. 97 - 102 (1987)