Publications of Alfred Wittinghofer

Daumke, O.; Weyand, M.; Chakrabarti, P. P.; Vetter, I. R.; Wittinghofer, A.: The GTPase-activating protein Rap1GAP uses a catalytic asparagine. Nature 429 (6988), 1, pp. 197 - 201 (2004)

Daumke, O.; Wittinghofer, A.; Weyand, M.: Purification, crystallization and preliminary structural characterization of human Rap1GAP. Acta Crystallographica Section D-Biological Crystallography 60 (Part 4), 1, pp. 752 - 754 (2004)

Shimada, A.; Nyitrai, M.; Vetter, I. R.; Kühlmann, D.; Bugyi, B.; Narumiya, S.; Geeves, M. A.; Wittinghofer, A.: The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization. Molecular Cell 13 (4), 1, pp. 511 - 522 (2004)

Seewald, M. J.; Kraemer, A.; Farkasovsky, M.; Körner, C.; Wittinghofer, A.; Vetter, I. R.: Biochemical characterization of the Ran-RanBP1-RanGAP system: Are RanBP proteins and the acidic tail of RanGAP required for the Ran-RanGAP GTPase reaction? Molecular and Cellular Biology 23 (22), 1, pp. 8124 - 8136 (2003)

Schlumberger, M. C.; Friebel, A.; Buchwald, G.; Scheffzek, K.; Wittinghofer, A.; Hardt, W.-D.: Amino acids of the bacterial toxin SopE involved in G nucleotide exchange on Cdc42. Journal of Biological Chemistry 278 (29), 1, pp. 27149 - 27159 (2003)

Rehmann, H.; Rüppel, A.; Bos, J. L.; Wittinghofer, A.: Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac. Journal of Biological Chemistry 278 (26), 1, pp. 23508 - 23514 (2003)

Kuiperij, H. B.; De Rooij, J.; Rehmann, H.; van Triest, M.; Wittinghofer, A.; Bos, J. L.; Zwartkruis, F. J. T.: Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2. Biochimica et Biophysica Acta - Molecular Cell Research 1593 (2-3), 1, pp. 141 - 149 (2003)

Rehmann, H.; Prakash, B.; Wolf, E.; Rueppel, A.; De Rooij, J.; Bos, J. L.; Wittinghofer, A.: Structure and regulation of the cAMP-binding domains of Epac2. Nature Structural Biology 10 (1), 1, pp. 26 - 32 (2003)

Rehmann, H.; Schwede, F.; Døskeland, S. O.; Wittinghofer, A.; Bos, J. L.: Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac. Journal of Biological Chemistry 278 (40), 1, pp. 38548 - 38556 (2003)

Würtele, M.; Jelich-Ottmann, C.; Wittinghofer, A.; Oecking, C.: Structural view of a fungal toxin acting on a 14-3-3 regulatory complex. EMBO Journal 22 (5), 1, pp. 987 - 994 (2003)

Baker, E. N.; Wittinghofer, A.: Proteins - from little acorns mighty oak trees grow - Editorial overview. Current Opinion in Structural Biology 12 (6), 1, pp. 743 - 745 (2002)

Kraemer, A.; Brinkmann, T.; Plettner, I.; Goody, R.; Wittinghofer, A.: Fluorescently labelled guanine nucleotide binding proteins to analyse elementary steps of GAP-catalysed reactions. Journal of Molecular Biology 324 (4), 1, pp. 763 - 774 (2002)

Wittinghofer, A.: Obg, a G domain with a beautiful extension. Structure 10 (11), 1, pp. 1471 - 1472 (2002)

Buchwald, G.; Friebel, A.; Galán, J. E.; Hardt, W.-D.; Wittinghofer, A.; Scheffzek, K.: Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE. EMBO Journal 21 (13), 1, pp. 3286 - 3295 (2002)

Hanzal-Bayer, M.; Renault, L.; Roversi, P.; Wittinghofer, A.; Hillig, R. C.: The complex of Arl2-GTP and PDEδ: from structure to function. EMBO Journal 21 (9), 1, pp. 2095 - 2106 (2002)

Brinkmann, T.; Daumke, O.; Herbrand, U.; Kühlmann, D.; Stege, P.; Ahmadian, M. R.; Wittinghofer, A.: Rap-specific GTPase activating protein follows an alternative mechanism. Journal of Biological Chemistry 277 (15), 1, pp. 12525 - 12531 (2002)

Wittinghofer, A.: Diverse mechanims for GTP hydrolysis by GTP-binding proteins. Abstracts of Papers of the American Chemical Society 223, 038-PHYS (2002)

Seewald, M. J.; Körner, C.; Wittinghofer, A.; Vetter, I. R.: RanGAP mediates GTP hydrolysis without an arginine finger. Nature 415 (6872), 1, pp. 662 - 666 (2002)

Ahmadian, M. R.; Wittinghofer, A.; Herrmann, C.: Fluorescence Methods in the Study of Small GTP-Binding Proteins. GTPase Protocols. The Ras Superfamily, 4, pp. 45 - 63 (2002)

Allin, C.; Ahmadian, M. R.; Wittinghofer, A.; Gerwert, K.: Monitoring the GAP catalyzed H-Ras GTPase reaction at atomic resolution in real time. Proceedings of the National Academy of Sciences of the USA 98 (14), 1, pp. 7754 - 7759 (2001)