Peter Bieling

Peter Bieling

Research Group Leader, Systemic Cell Biology 

Regulatory mechanisms of cell morphology


Publications

2023

Oosterheert W, Blanc FEC, Roy A, Belyy A, Sanders MB, Hofnagel O, Hummer G, Bieling P#, Raunser  (2023). Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments. Nat Struct Mol Biol.
Source

Bieling P, Rottner K (2023). From WRC to Arp2/3: Collective molecular mechanisms of branched actin network assembly. Curr Opin Cell Biol 
Source

2022

Belyy A, Lindemann F, Roderer D, Funk J, Bardiaux B, Protze J, Bieling P, Oschkinat H, Raunser S (2022). Mechanism of threonine ADP-ribosylation of F-actin by a Tc toxin. Nat Commun
Source

Li TD, Bieling P, Weichsel J, Mullins RD, Fletcher DA (2021). The molecular mechanism of load adaptation by branched actin networks. Elife 
Source

2021

Funk J, Merino F, Schaks M, Rottner K, Raunser S, Bieling P# (2021). A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks. Nature Communications 
Source

2019

Funk J, Merino F, Venkova L, Heydenreich L, Kierfeld J, Vargas P, Raunser S, Piel M, Bieling P# (2019). Profilin and formin constitute a pacemaker system for robust actin filament growth. eLife
doi: 10.7554/eLife.50963.

Golding AE*, Visco I*, Bieling P#, Bement WM# (2019). Extraction of active RhoGTPases by RhoGDI regulates spatiotemporal patterning of RhoGTPases. eLife
doi: 10.7554/eLife.50471.

Hansen SD, Huang WYC, Lee YK, Bieling P, Christensen SM, Groves JT (2019). Stochastic geometry sensing and polarization in a lipid kinase-phosphatase competitive reaction. PNAS
doi: 10.1073/pnas.1901744116.

2018

Mullins RD, Bieling P, Fletcher DA (2018). From solution to surface to filament: actin flux into branched networks. Biophys Rev
doi: 10.1007/s12551-018-0469-5.

Merino F, Pospich S, Funk J, Wagner T, Küllmer F, Arndt HD, Bieling P & Raunser S (2018). Structural transitions of F-actin upon ATP hydrolysis at near-atomic resolution revealed by cryo-EM. Nat Struct Mol Biol
doi: 10.1038/s41594-018-0074-0.

Schwille P, Spatz J, Landfester K, Bodenschatz E, Herminghaus S, Sourjik V, Erb T, Bastiaens P, Lipowsky R, Hyman A, Dabrock P, Baret JC, Vidakovic-Koch T, Bieling P, Dimova R, Mutschler H, Robinson T, Tang D, Wegner S, Sundmacher K (2018). MaxSynBio - Avenues towards creating cells from the bottom up. Angew Chem Int Engl
doi: 10.1002/anie.201802288.

Bieling P*#, Hansen SD#, Akin O, Li TD, Hayden CC, Fletcher DA#, Mullins RD# (2018). WH2 and proline‐rich domains of WASP‐family proteins collaborate to accelerate actin filament elongation. EMBO J.
doi: 10.15252/embj.20179703.


2016

Bieling P*, Li T-D*, Weichsel J, McGorty R, Jreij P, Huang B, Fletcher DA#, Mullins RD# (2016). Force Feedback Controls Motor Activity and Mechanical Properties of Self-Assembling Branched Actin Networks. Cell 164 (1-2), S. 115-127
doi: 10.1016/j.cell.2015.11.057.

Köster DV, Husain K, Iljazi E, Bhat A, Bieling, P, Mullins RD, Rao M, Mayor S (2016). Actomyosin dynamics drive local membrane component organization in an in vitro active composite layer. PNAS 113 (12), S. E1645-E1654
doi: 10.1073/pnas.1514030113 .


2011

Maurer SP, Bieling P, Cope J, Hoenger A, Surrey T (2011). GTPgammaS microtubules mimic the growing microtubule end structure recognized by end-binding proteins (EBs). PNAS 108 (10), S. 3988-3993
doi: 10.1073/pnas.1014758108.

Roostalu J, Hentrich C, ,Bieling P. Telley IA, Schiebel E, Surrey T (2011). Directional switching of the kinesin Cin8 through motor coupling. Science 332 (6025), S. 94-99
doi: 10.1126/science.1199945. 

# = (co-)corresponding author

* = co-first author


before 2011

Bieling P, Kronja I, Surrey T (2010). Microtubule motility on reconstituted meiotic chromatin. Current Biology 20 (8), S. 763-769
doi: 10.1016/j.cub.2010.02.067. 

Bieling P, Telley IA, Surrey T (2010). A minimal midzone protein module controls formation and length of antiparallel microtubule overlaps. Cell 142 (3), S. 420-432
doi: http://dx.doi.org/10.1016/j.cell.2010.06.033.

Kronja I, Kruljac-Letunic A, Caudron-Herger M, Bieling P, Karsenti, E (2009). XMAP215-EB1 interaction is required for proper spindle assembly and chromosome segregation in Xenopus egg extract. Molecular Biology of the Cell 20 (11), S. 2684-2696
 doi: 10.1091/mbc.E08-10-1051.

Telley IA, Bieling P, Surrey T (2009). Obstacles on the microtubule reduce the processivity of Kinesin-1 in a minimal in vitro system and in cell extract. Biophysical Journal 96 (8), S. 3341-3353
doi: 10.1016/j.bpj.2009.01.015.

Bieling P, Kandels-Lewis S, Telley IA, van Dijk J, Janke C, Surrey T (2008). CLIP-170 tracks growing microtubule ends by dynamically recognizing composite EB1/tubulin-binding sites. The Journal of Cell Biology 183 (7), S. 1223-1233
doi: 10.1083/jcb.200809190.

Bieling P, Telley IA, Piehler J, Surrey T (2008). Processive kinesins require loose mechanical coupling for efficient collective motility. EMBO Reports 9 (11), S. 1121-1127
doi: 10.1038/embor.2008.169.

Espeut J, Gaussen A, Bieling P, Morin V, Prieto, S, Fesquet D, Surrey T, Abrieu A (2008). Phosphorylation relieves autoinhibition of the kinetochore motor Cenp-E. Molecular Cell 29 (5), S. 637-643
doi: 10.1016/j.molcel.2008.01.004.

Uteng M, Hentrich C, Miura K, Bieling P, Surrey T (2008). Poleward transport of Eg5 by dynein-dynactin in Xenopus laevis egg extract spindles. The Journal of Cell Biology 182(4), S. 715-726
doi: 10.1083/jcb.200801125.

Bieling P*, Laan L*, Schek H, Munteanu EL, Sandblad L, Dogterom M#, Brunner D#, Surrey T# (2007). Reconstitution of a microtubule plus-end tracking system in vitro. Nature 450 (7172), S. 1100-1105
doi:10.1038/nature06386.

Bieling B, Beringer M, Adio S, Rodnina MV (2006). Peptide bond formation does not involve acid-base catalysis by ribosomal residues. Nature Structural and Molecular Biology 13 (5), S. 423-428
doi: 10.1038/nsmb1091.

Beringer M, Bruell C, Xiong L, Pfister P, Bieling P, Katunin VI, Mankin AS, Böttger EC, Rodnina MV (2005).  Essential mechanisms in the catalysis of peptide bond formation on the ribosome. The Journal of Biological Chemistry 280 (43), S. 36065-36072
doi: 10.1074/jbc.M507961200.

Rodnina MV, Beringer M, Bieling P (2005) . Ten remarks on peptide bond formation on the ribosome. Biochemical Society Transactions 33 (3), S. 493-498
doi: 10.1042/BST0330493.

# = (co-)corresponding author

* = co-first author

Go to Editor View