Mechanism of loading and translocation of type VI secretion system effector Tse6

Quentin D, Ahmad S, Shanthamoorthy P, Mougous JD, Whitney JC, Raunser S (2018). Nat Microbiol

 doi: 10.1038/s41564-018-0238-z. 

Using Cryo-EM the Raunser group together with the Whitney group from the McMaster University and the Mougous group from the University of Washingtion analysed the structures of the

Pseudomonas aeruginosa effector Tse6 loaded onto the T6SS spike protein VgrG1 in solution and embedded in lipid nanodiscs.

 

Model for Tse6 effector loading and delivery

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