Elucidation of autophagy using novel chemical probes

Research report (imported) 2014 - Max Planck Institute of Molecular Physiology

Wu, Yaowen
Chemical Genomics Centre der Max-Planck-Gesellschaft
Autophagy is an important self-eating process in cells to eliminate or recycle cellular components or proteins out of use and takes place in cell organelles called autophagosomes. Development of autophagosome membranes involves complicated assemblies of lipids and proteins, highly regulated by a network of signals. Chemical probes including chemically modified proteins and small molecules enable researchers to elucidate the regulation mechanism of autophagy and molecular basis of autophagosome formation, previously not possible using traditional biochemical and cell biological approaches.

For the full text, see the German version.

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