How to control chromosome segregation in mitosis: the kinetochore at the heart of the check point
Research report (imported) 2015 - Max Planck Institute of Molecular Physiology
During cell division, from each chromosome, the carriers of a cell's genome, identical copies are made in the mother cell. These are later transmitted to the two daughter cells in a process called chromosome “segregation”. Chromosome segregation requires specialized structures named kinetochores, which are established on a specialized region of each chromosome named the centromere. Kinetochores are multi-protein assemblies, and they are required to connect the chromosomes to a dynamic structure, the mitotic spindle, whose main function is to separate the replicated chromosomes.