After 30 years close to the finish line: the molecular basis of sugar transport in the small intestine and the kidney
Research report (imported) 2004 - Max Planck Institute of Molecular Physiology
This report details the increase in knowledge on the basic mechanisms in sugar absorption in the intestine and reabsorption in the kidney. It describes how the biophysical principles of cell asymmetry and asymmetry of the transport molecules are realized at the molecular level and how the problems of transport selectivity and transport energetics are solved by specific subdomains of the transporter. Thereby a complex series of events is described which in the end leads to the vectorial transport of sugars across the membrane and across the cell. The report also illustrates how the combination of the most modern techniques from different areas of Life Sciences is essential for the progress, this transdisciplinary research is one of the highlights of the research conducted at the Max Planck Institute in Dortmund.