Publications of Alfred Wittinghofer
All genres
Journal Article (246)
21.
Journal Article
7, 11366, pp. 1 - 9 (2016)
PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity. Nature Communications 22.
Journal Article
29 (3), pp. 251 - 253 (2016)
Selective Targeting of the KRAS G12C Mutant: Kicking KRAS When It's Down. Cancer Cell 23.
Journal Article
7 (4), pp. 222 - 230 (2016)
Sorting of lipidated cargo by the Arl2/Arl3 system. Small GTPases 24.
Journal Article
23 (25), pp. 6083 - 6093 (2016)
Development of Pyridazinone Chemotypes Targeting the PDEδ Prenyl Binding Site. Chemistry – A European Journal 25.
Journal Article
16 (12), pp. 1583 - 1585 (2015)
The N- and C-terminal ends of RPGR can bind to PDE6δ. EMBO Reports 26.
Journal Article
A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins. eLife, pp. e11859:1 - e11859:28 (2015)
27.
Journal Article
23 (11), pp. 2122 - 2132 (2015)
The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function. Structure 28.
Journal Article
109 (8), pp. 1619 - 1629 (2015)
Effect of the N-Terminal Helix and Nucleotide Loading on the Membrane and Effector Binding of Arl2/3. Biophysical Journal 29.
Journal Article
35 (5), pp. e00254:1 - e00254:12 (2015)
Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations. Bioscience Reports 30.
Journal Article
58 (9), pp. 3751 - 3756 (2015)
Structural Characterization of LRRK2 Inhibitors. Journal of Medicinal Chemistry 31.
Journal Article
465 (1), pp. 139 - 147 (2015)
Revisiting the Roco G-protein cycle. Biochemical Journal 32.
Journal Article
8 (1), pp. 1 - 9 (2014)
C2 Domains as Protein-Protein Interaction Modules in the Ciliary Transition Zone. Cell Reports 33.
Journal Article
57 (12), pp. 5435 - 5448 (2014)
Structure Guided Design and Kinetic Analysis of Highly Potent Benzimidazole Inhibitors Targeting the PDEδ Prenyl Binding Site. Journal of Medicinal Chemistry 34.
Journal Article
395 (2), pp. 169 - 180 (2014)
Human septin isoforms and the GDP-GTP cycle. Biological Chemistry 35.
Journal Article
15 (13), pp. 1991 - 1997 (2014)
Predicted incorporation of non-native substrates by a polyketide synthase yields bioactive natural product derivatives. ChemBioChem: A European Journal of Chemical Biology 36.
Journal Article
457 (2), pp. 301 - 311 (2014)
Structural insights into the small G protein Arl13B and implications for Joubert syndrome. Biochemical Journal 37.
Journal Article
99 (11), pp. 807 - 808 (2013)
Introductory editorial for the proteins special issue of biopolymers. Biopolymers 38.
Journal Article
497 (7451), 1, pp. 638 - 642 (2013)
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature 39.
Journal Article
14 (5), 1, pp. 465 - 472 (2013)
The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo. EMBO Reports 40.
Journal Article
110 (1), 1, pp. 111 - 116 (2013)
Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes. Proceedings of the National Academy of Sciences of the United States of America