Publications of Shehab Ismail
All genres
Journal Article (8)
1.
Journal Article
56 (9), pp. 2423 - 2428 (2017)
A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2. Angewandte Chemie International Edition 2.
Journal Article
129 (9), pp. 2463 - 2468 (2017)
A PDE6d-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2. Angewandte Chemie 3.
Journal Article
7, 11360, pp. 1 - 9 (2016)
Identification of pyrazolopyridazinones as PDEδ inhibitors. Nature Communications 4.
Journal Article
109 (8), pp. 1619 - 1629 (2015)
Effect of the N-Terminal Helix and Nucleotide Loading on the Membrane and Effector Binding of Arl2/3. Biophysical Journal 5.
Journal Article
57 (12), pp. 5435 - 5448 (2014)
Structure Guided Design and Kinetic Analysis of Highly Potent Benzimidazole Inhibitors Targeting the PDEδ Prenyl Binding Site. Journal of Medicinal Chemistry 6.
Journal Article
15 (13), pp. 1991 - 1997 (2014)
Predicted incorporation of non-native substrates by a polyketide synthase yields bioactive natural product derivatives. ChemBioChem: A European Journal of Chemical Biology 7.
Journal Article
497 (7451), 1, pp. 638 - 642 (2013)
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature 8.
Journal Article
14 (5), 1, pp. 465 - 472 (2013)
The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo. EMBO Reports